Featured Publications
Contemporary American and European Guidelines for Heart Failure Management JACC: Heart Failure Guideline Comparison
Ostrominski J, DeFilippis E, Bansal K, Riello R, Bozkurt B, Heidenreich P, Vaduganathan M. Contemporary American and European Guidelines for Heart Failure Management JACC: Heart Failure Guideline Comparison. JACC Heart Failure 2024, 12: 810-825. PMID: 38583167, DOI: 10.1016/j.jchf.2024.02.020.Peer-Reviewed Original ResearchConceptsEuropean Society of CardiologySocial determinants of healthDeterminants of healthHealth care disparitiesHeart failureClinical practice recommendationsManagement of heart failureCare disparitiesDevice-based therapiesSocial determinantsEvidence-based pharmacotherapyGroup of patientsHF careSociety of CardiologyClinical careHF preventionPotential downstream implicationsCardiac amyloidosisAmerican CollegeHF risk predictionPractice recommendationsManagement pathwayNoncardiac comorbiditiesRisk predictionHF stagesPragmatic trial of messaging to providers about treatment of acute heart failure: The PROMPT-AHF trial
Ghazi L, O'Connor K, Yamamoto Y, Fuery M, Sen S, Samsky M, Riello R, Huang J, Olufade T, McDermott J, Inzucchi S, Velazquez E, Wilson F, Desai N, Ahmad T. Pragmatic trial of messaging to providers about treatment of acute heart failure: The PROMPT-AHF trial. American Heart Journal 2022, 257: 111-119. PMID: 36493842, DOI: 10.1016/j.ahj.2022.12.002.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyAcute heart failureHeart failurePragmatic trialElectronic health recordsSubstantial health care costsBest practice advisoryReduced ejection fractionUsual care armHealth recordsTime of dischargeEvidence-based careHealth care costsClinical decision support systemAHF patientsCare armEligible patientsHF hospitalizationInpatient initiationCardiovascular deathMedication classesEjection fractionMedical therapyPrimary outcomePractice advisoryRationale and design of a cluster-randomized pragmatic trial aimed at improving use of guideline directed medical therapy in outpatients with heart failure: PRagmatic trial of messaging to providers about treatment of heart failure (PROMPT-HF)
Ghazi L, Desai NR, Simonov M, Yamamoto Y, O'Connor KD, Riello RJ, Huang J, Olufade T, McDermott J, Inzucchi SE, Velazquez EJ, Wilson FP, Ahmad T. Rationale and design of a cluster-randomized pragmatic trial aimed at improving use of guideline directed medical therapy in outpatients with heart failure: PRagmatic trial of messaging to providers about treatment of heart failure (PROMPT-HF). American Heart Journal 2021, 244: 107-115. PMID: 34808104, DOI: 10.1016/j.ahj.2021.11.010.Peer-Reviewed Original ResearchMeSH KeywordsHeart FailureHumansOutpatientsStroke VolumeUnited StatesVentricular Dysfunction, LeftVentricular Function, LeftConceptsGuideline-directed medical therapyBest practice alertLeft ventricular ejection fractionHeart failureUsual careMedical therapyPragmatic trialElectronic health recordsEjection fractionCluster-randomized pragmatic trialLarge integrated healthcare systemDays post randomizationAppropriate medical therapyHeart Failure TrialReduced ejection fractionUsual care groupCommon chronic illnessGlomerular filtration rateVentricular ejection fractionRecent blood pressureIntegrated healthcare systemUse of guidelinesLow-cost interventionCreatinine levelsReal-world practiceAdoption of sacubitril-valsartan in the Medicare population
Kahn PA, Riello RJ, Ahmad T, Desai NR. Adoption of sacubitril-valsartan in the Medicare population. American Heart Journal 2020, 223: 81-83. PMID: 32179259, DOI: 10.1016/j.ahj.2020.02.009.Peer-Reviewed Original ResearchReal World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure A U.S. Center’s Experience
Griffin M, Soufer A, Goljo E, Colna M, Rao VS, Jeon S, Raghavendra P, D'Ambrosi J, Riello R, Coca SG, Mahoney D, Jacoby D, Ahmad T, Chen M, Tang WHW, Turner J, Mullens W, Wilson FP, Testani JM. Real World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure A U.S. Center’s Experience. JACC Heart Failure 2020, 8: 199-208. PMID: 32035891, PMCID: PMC7814403, DOI: 10.1016/j.jchf.2019.10.012.Peer-Reviewed Original ResearchConceptsAcute decompensated heart failureHypertonic saline administrationHypertonic saline therapyHypertonic salineSaline administrationSaline therapyDiuretic efficiencyUrine outputSerum sodiumWeight lossAcute decompensated heartDecompensated heart failureCohort of patientsTotal urine outputReal-world safetyU.S. academic medical centersAcademic medical centerLarge U.S. academic medical centerDiuretic doseCenter experienceHeart failureMetabolic derangementsPrimary analytic approachRespiratory statusClinical variables
2024
Medicare Coverage and Patient Out-of-Pocket Costs for Cardiovascular-Kidney-Metabolic Medications
Young G, Bansal K, Riello R, Clark K, Dhruva S, Faridi K, Desai N. Medicare Coverage and Patient Out-of-Pocket Costs for Cardiovascular-Kidney-Metabolic Medications. JAMA Network Open 2024, 7: e2412437. PMID: 38771578, PMCID: PMC11109768, DOI: 10.1001/jamanetworkopen.2024.12437.Peer-Reviewed Original Research
2022
Thirty-Day and 90-Day Episode of Care Spending Following Heart Failure Hospitalization Among Medicare Beneficiaries
Reinhardt SW, Clark KAA, Xin X, Parzynski CS, Riello R, Sarocco P, Ahmad T, Desai NR. Thirty-Day and 90-Day Episode of Care Spending Following Heart Failure Hospitalization Among Medicare Beneficiaries. Circulation Cardiovascular Quality And Outcomes 2022, 15: e008069. PMID: 35861780, DOI: 10.1161/circoutcomes.121.008069.Peer-Reviewed Original ResearchConceptsHypertensive heart diseaseIndex hospitalizationMedicare beneficiariesPost-acute care spendingService administrative claims dataMedicare Bundled PaymentsHeart failure admissionsHeart failure hospitalizationPrimary discharge diagnosisChronic kidney diseaseAdministrative claims dataCare spendingPostacute care spendingSkilled nursing facilitiesCare Improvement ProgramDrivers of costDiastolic HFHF careHF hospitalizationSystolic HFFailure hospitalizationDischarge diagnosisKidney diseaseObservation staysPostacute care
2020
Association Between US Administration Endorsement of Hydroxychloroquine for COVID-19 and Outpatient Prescribing
Harrigan J, Hubbard R, Thomas S, Riello R, Bange E, Mamtani M, Mamtani R. Association Between US Administration Endorsement of Hydroxychloroquine for COVID-19 and Outpatient Prescribing. Journal Of General Internal Medicine 2020, 35: 2826-2828. PMID: 32542496, PMCID: PMC7295147, DOI: 10.1007/s11606-020-05938-4.Peer-Reviewed Original Research
2018
The use of betrixaban for extended prophylaxis of venous thromboembolism events in hospitalized, high-risk patients.
Dobesh PP, Ahuja T, Davis GA, Fatodu H, Francis WH, Hull FP, Johnson GL, Lenchus JD, Lenoir JG, McPherson C, Nemeth J, Riello RJ. The use of betrixaban for extended prophylaxis of venous thromboembolism events in hospitalized, high-risk patients. The American Journal Of Managed Care 2018, 24: s475-s482. PMID: 30452199.Peer-Reviewed Original ResearchBest practices for implementing venous thromboembolism prophylaxis across the continuum of care.
Dobesh PP, Ahuja T, Davis GA, Fatodu H, Francis WH, Hull FP, Johnson GL, Lenchus JD, Lenoir JG, McPherson C, Nemeth J, Riello RJ. Best practices for implementing venous thromboembolism prophylaxis across the continuum of care. The American Journal Of Managed Care 2018, 24: s483-s488. PMID: 30452200.Peer-Reviewed Original ResearchVenous thromboembolism in acute medically ill patients: identifying unmet needs and weighing the value of prophylaxis.
Dobesh PP, Ahuja T, Davis GA, Fatodu H, Francis WH, Hull FP, Johnson GL, Lenchus JD, Lenoir JG, McPherson C, Nemeth J, Riello RJ. Venous thromboembolism in acute medically ill patients: identifying unmet needs and weighing the value of prophylaxis. The American Journal Of Managed Care 2018, 24: s468-s474. PMID: 30452198.Peer-Reviewed Original Research