Effect of Inotropes on Patient-Reported Health Status in End-Stage Heart Failure
Clarke JD, Riello R, Allen LA, Psotka MA, Teerlink JR, Lindenfeld J, Desai NR, Ahmad T. Effect of Inotropes on Patient-Reported Health Status in End-Stage Heart Failure. Circulation Heart Failure 2021, 14: e007759. PMID: 33530705, DOI: 10.1161/circheartfailure.120.007759.Peer-Reviewed Original ResearchConceptsEnd-stage heart failureReduced ejection fractionHealth-related qualityPatient-reported health statusEffect of inotropesHeart failureHealth status domainsEjection fractionHealth statusFunctional statusPositive inotropesStatus domainsAvailable clinical trial dataMorbidity/mortalityPopulation of patientsPatient-centered outcomesHealth status outcomesClinical trial dataFunctional capacity changesQuantity of lifeWeb of ScienceInotrope therapyInotrope useCalcium sensitizerSurvival benefitWhy has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials
Ahmad T, Miller PE, McCullough M, Desai NR, Riello R, Psotka M, Böhm M, Allen LA, Teerlink JR, Rosano GMC, Lindenfeld J. Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials. European Journal Of Heart Failure 2019, 21: 1064-1078. PMID: 31407860, PMCID: PMC6774302, DOI: 10.1002/ejhf.1557.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHeart failureClinical trialsPositive inotropic therapyChronic heart failureReduced ejection fractionAdvanced heart failureCurrent pharmacological therapiesPopulation of patientsDefinitive clinical trialsVentricular assist deviceQuality of lifePositive cardiac inotropeLong-term useInotropic therapyHeart transplantationSurvival benefitCardiac haemodynamicsEjection fractionPharmacological therapyCardiac outputFuture trialsNeurohormonal systemsFunctional statusPositive inotropesPositive inotropy