Featured Publications
Medial prefrontal D1 dopamine neurons control food intake
Land BB, Narayanan NS, Liu RJ, Gianessi CA, Brayton CE, M Grimaldi D, Sarhan M, Guarnieri DJ, Deisseroth K, Aghajanian GK, DiLeone RJ. Medial prefrontal D1 dopamine neurons control food intake. Nature Neuroscience 2014, 17: 248-253. PMID: 24441680, PMCID: PMC3968853, DOI: 10.1038/nn.3625.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnalysis of VarianceAnimalsBiophysicsCalcium-Calmodulin-Dependent Protein Kinase Type 2ChannelrhodopsinsEatingElectric StimulationFemaleFood DeprivationFunctional LateralityGene Expression RegulationIn Vitro TechniquesLuminescent ProteinsMaleMembrane PotentialsMiceMice, Inbred C57BLMice, TransgenicNeural InhibitionNeural PathwaysNeuronsOptogeneticsPatch-Clamp TechniquesPhotic StimulationPrefrontal CortexReceptors, Dopamine D1Time Factors
2019
Orbitofrontal Circuits Control Multiple Reinforcement-Learning Processes
Groman SM, Keistler C, Keip AJ, Hammarlund E, DiLeone RJ, Pittenger C, Lee D, Taylor JR. Orbitofrontal Circuits Control Multiple Reinforcement-Learning Processes. Neuron 2019, 103: 734-746.e3. PMID: 31253468, PMCID: PMC6893860, DOI: 10.1016/j.neuron.2019.05.042.Peer-Reviewed Original ResearchOptogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects
Hare BD, Shinohara R, Liu RJ, Pothula S, DiLeone RJ, Duman RS. Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects. Nature Communications 2019, 10: 223. PMID: 30644390, PMCID: PMC6333924, DOI: 10.1038/s41467-018-08168-9.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexAntidepressant effectsPyramidal cellsNovel rapid-acting antidepressantsRapid antidepressant effectsRapid-acting antidepressantsRapid antidepressant responseRapid antidepressant actionsAntidepressant actionAntidepressant responsePyramidal neuronsTherapeutic responseDRD2 dopamine receptorAnxiolytic responseDopamine receptorsSomatic stimulationTarget neuronsImpaired functionMajor subtypesOptogenetic stimulationParticular subtypeDownstream circuitryPrefrontal cortexKetamineNeurons
2016
Activity of D1/2 Receptor Expressing Neurons in the Nucleus Accumbens Regulates Running, Locomotion, and Food Intake
Zhu X, Ottenheimer D, DiLeone RJ. Activity of D1/2 Receptor Expressing Neurons in the Nucleus Accumbens Regulates Running, Locomotion, and Food Intake. Frontiers In Behavioral Neuroscience 2016, 10: 66. PMID: 27147989, PMCID: PMC4828436, DOI: 10.3389/fnbeh.2016.00066.Peer-Reviewed Original ResearchD2 neuronsFood intakeEnergy intakeExcessive energy intakeNeuronal manipulationInhibition of D1Expressing NeuronsD2 receptorsDesigner receptorsD1 neuronsNucleus accumbensDopamine pathwayNeuron inhibitionWeight controlLocomotor activityBrain regionsDrug strategiesWeight gainBehavioral effectsNeuronsIntakeWheel runningEnergy expenditureReward behaviorNeural activity
2012
Prefrontal D1 dopamine signaling is required for temporal control
Narayanan NS, Land BB, Solder JE, Deisseroth K, DiLeone RJ. Prefrontal D1 dopamine signaling is required for temporal control. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 20726-20731. PMID: 23185016, PMCID: PMC3528521, DOI: 10.1073/pnas.1211258109.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBehavior, AnimalBiological ClocksMaleMiceMice, TransgenicModels, NeurologicalNeural PathwaysOptogeneticsPrefrontal CortexRatsReceptors, Dopamine D1RewardRNA InterferenceRNA, Small InterferingSignal TransductionSynaptic TransmissionTime FactorsTyrosine 3-MonooxygenaseVentral Tegmental AreaConceptsVentral tegmental areaD1 dopamine receptorsDopamine receptorsTegmental areaDopaminergic projectionsPrefrontal neuronsMidbrain ventral tegmental areaD2 dopamine receptorsDopaminergic inputD1 receptorsDopaminergic neurotransmissionD1 dopamineDopaminergic diseasesTyrosine hydroxylaseDopamine signalingReceptorsPharmacological disruptionSelective inhibitionGoal-directed behaviorNeuronsRNA interferenceTiming taskBehavioral goalsControlNeurotransmission