2019
Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects
Hare BD, Shinohara R, Liu RJ, Pothula S, DiLeone RJ, Duman RS. Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects. Nature Communications 2019, 10: 223. PMID: 30644390, PMCID: PMC6333924, DOI: 10.1038/s41467-018-08168-9.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexAntidepressant effectsPyramidal cellsNovel rapid-acting antidepressantsRapid antidepressant effectsRapid-acting antidepressantsRapid antidepressant responseRapid antidepressant actionsAntidepressant actionAntidepressant responsePyramidal neuronsTherapeutic responseDRD2 dopamine receptorAnxiolytic responseDopamine receptorsSomatic stimulationTarget neuronsImpaired functionMajor subtypesOptogenetic stimulationParticular subtypeDownstream circuitryPrefrontal cortexKetamineNeurons
2015
Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions
Fuchikami M, Thomas A, Liu R, Wohleb ES, Land BB, DiLeone RJ, Aghajanian GK, Duman RS. Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 8106-8111. PMID: 26056286, PMCID: PMC4491758, DOI: 10.1073/pnas.1414728112.Peer-Reviewed Original ResearchConceptsIL-PFCOptogenetic stimulationAntidepressant actionAnxiolytic effectsSystemic ketamineLayer V pyramidal neuronsSystemic ketamine administrationInfralimbic prefrontal cortexPrecise cellular mechanismsKetamine infusionKetamine administrationPyramidal neuronsAnxiolytic actionDepressed patientsSpine synapsesSynaptic responsesNeuronal inactivationRodent modelsNeuronal activityKetaminePrefrontal cortexBehavioral actionsCellular mechanismsStimulationPatients