Featured Publications
Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption
Bond CW, Trinko R, Foscue E, Furman K, Groman SM, Taylor JR, DiLeone RJ. Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption. Journal Of Neuroscience 2020, 40: 4727-4738. PMID: 32354856, PMCID: PMC7294796, DOI: 10.1523/jneurosci.3054-18.2020.Peer-Reviewed Original ResearchConceptsControl food intakeNAc projectionsFood intakeAccumbens projectionsLateral hypothalamusMesolimbic circuitsFood consumptionNucleus accumbens projectionsFood-seeking behaviorNAC controlVTA pathwayInhibitory projectionsMale miceNAc shellOptogenetic activationFiber photometryOptogenetic inhibitionPermissive rolePharmacological studiesDrug rewardVTAConsummatory behaviorIntakeAdaptive inhibitionNeural activityMedial prefrontal D1 dopamine neurons control food intake
Land BB, Narayanan NS, Liu RJ, Gianessi CA, Brayton CE, M Grimaldi D, Sarhan M, Guarnieri DJ, Deisseroth K, Aghajanian GK, DiLeone RJ. Medial prefrontal D1 dopamine neurons control food intake. Nature Neuroscience 2014, 17: 248-253. PMID: 24441680, PMCID: PMC3968853, DOI: 10.1038/nn.3625.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnalysis of VarianceAnimalsBiophysicsCalcium-Calmodulin-Dependent Protein Kinase Type 2ChannelrhodopsinsEatingElectric StimulationFemaleFood DeprivationFunctional LateralityGene Expression RegulationIn Vitro TechniquesLuminescent ProteinsMaleMembrane PotentialsMiceMice, Inbred C57BLMice, TransgenicNeural InhibitionNeural PathwaysNeuronsOptogeneticsPatch-Clamp TechniquesPhotic StimulationPrefrontal CortexReceptors, Dopamine D1Time Factors
2016
Innate Fear-Induced Weight Regulation in the C57BL/6J Mouse
Genné-Bacon EA, Trinko JR, DiLeone RJ. Innate Fear-Induced Weight Regulation in the C57BL/6J Mouse. Frontiers In Behavioral Neuroscience 2016, 10: 132. PMID: 27458352, PMCID: PMC4930939, DOI: 10.3389/fnbeh.2016.00132.Peer-Reviewed Original ResearchHigh-fat dietWeight regulationBody weightBrown adipose thermogenesisDifferential weight gainWeek old miceLong-term neural plasticityDorsomedial hypothalamusFat dietAdipose thermogenesisC57BL/6J miceDiet groupFood intakeBA groupNeural plasticityChronic stressWeight gainAversive doseMiceΔFosB proteinButyric acidMT exposureActivity levelsUnderlying mechanismMetabolic adaptationActivity of D1/2 Receptor Expressing Neurons in the Nucleus Accumbens Regulates Running, Locomotion, and Food Intake
Zhu X, Ottenheimer D, DiLeone RJ. Activity of D1/2 Receptor Expressing Neurons in the Nucleus Accumbens Regulates Running, Locomotion, and Food Intake. Frontiers In Behavioral Neuroscience 2016, 10: 66. PMID: 27147989, PMCID: PMC4828436, DOI: 10.3389/fnbeh.2016.00066.Peer-Reviewed Original ResearchD2 neuronsFood intakeEnergy intakeExcessive energy intakeNeuronal manipulationInhibition of D1Expressing NeuronsD2 receptorsDesigner receptorsD1 neuronsNucleus accumbensDopamine pathwayNeuron inhibitionWeight controlLocomotor activityBrain regionsDrug strategiesWeight gainBehavioral effectsNeuronsIntakeWheel runningEnergy expenditureReward behaviorNeural activity