2024
Smartband-based smoking detection and real-time brief mindfulness intervention: findings from a feasibility clinical trial
Horvath M, Pittman B, O’Malley S, Grutman A, Khan N, Gueorguieva R, Brewer J, Garrison K. Smartband-based smoking detection and real-time brief mindfulness intervention: findings from a feasibility clinical trial. Annals Of Medicine 2024, 56: 2352803. PMID: 38823419, PMCID: PMC11146247, DOI: 10.1080/07853890.2024.2352803.Peer-Reviewed Original ResearchConceptsBrief mindfulness interventionsMindfulness exercisesTreatment startersMindfulness interventionSmoking interventionsOnline mindfulness trainingWhite non-HispanicMindfulness trainingTreatment fidelityFeasibility measuresHelpfulness ratingsNon-HispanicDaily smokersPredicting smokingReduce smokingExerciseSmokingCigarette smokingInterventionLow completenessAdherenceParticipantsSmartbandAcceptanceMindfulness
2023
Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial
Grilo C, Lydecker J, Gueorguieva R. Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2023, 53: 7775-7784. PMID: 37366017, PMCID: PMC10751383, DOI: 10.1017/s0033291723001800.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderBinge-eating remissionAcute treatmentMaintenance treatmentBinge-eating frequencyDouble-blind placebo-controlled trialBehavioral weight loss therapyWeight lossCo-occurring obesitySuccessful acute treatmentPlacebo-controlled trialWeight loss therapySignificant additional weight lossSingle-site trialAdditional weight lossAcute efficacyRemission rateAdult patientsComorbid obesityBupropionInitial interventionPosttreatment assessmentRespondersPlaceboGambling participation among Connecticut adolescents from 2007 to 2019: Potential risk and protective factors
Stefanovics E, Gueorguieva R, Zhai Z, Potenza M. Gambling participation among Connecticut adolescents from 2007 to 2019: Potential risk and protective factors. Journal Of Behavioral Addictions 2023, 12: 490-499. PMID: 37335777, PMCID: PMC10316163, DOI: 10.1556/2006.2023.00027.Peer-Reviewed Original ResearchConceptsPrevalence of gamblingGambling participationPatterns of gamblingSocial supportSocial support programsGambling advertisementsTraumatic experiencesMedia coverageState of ConnecticutSocio-demographic characteristicsAffective concernsSubstance useConnecticut high school studentsGamblingAdolescent gamblingAnonymous self-completed questionnairePotential risk factorsParticipationSupport programsPublic health concernSelf-completed questionnaireCurrent substance useSocio-demographic dataCross-sectional surveyWarrants further studyCognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial
Grilo C, Lydecker J, Gueorguieva R. Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial. International Journal Of Eating Disorders 2023, 56: 1544-1553. PMID: 37144325, PMCID: PMC10524840, DOI: 10.1002/eat.23975.Peer-Reviewed Original ResearchConceptsInitial acute treatmentBinge-eating disorderCognitive behavioral therapyAcute treatmentBinge-eating frequencyInitial interventionTherapist-led cognitive behavioural therapyInitial pharmacological treatmentTreat remission ratesEvidence-based treatmentsSingle-site trialAcute efficacyRemission rateAdult patientsInitial treatmentPharmacological treatmentPatientsPosttreatment assessmentBehavioral treatmentSufficient benefitTherapyDisordersInterventionTreatmentPharmacotherapy
2020
Data Visualization Tools of Tobacco Product Use Patterns, Transitions and Sex Differences in the PATH Youth Data
Gueorguieva R, Buta E, Simon P, Krishnan-Sarin S, O’Malley S. Data Visualization Tools of Tobacco Product Use Patterns, Transitions and Sex Differences in the PATH Youth Data. Nicotine & Tobacco Research 2020, 22: 1901-1908. PMID: 32219313, PMCID: PMC7542650, DOI: 10.1093/ntr/ntaa056.Peer-Reviewed Original ResearchConceptsTobacco product use patternsMultiple tobacco product useProduct use patternsTobacco product useE-cigarettesProduct useTobacco productsHookah useWave 1Wave 2Common tobacco productsTobacco use patternsE-cigarette useSex differencesInitiation of usePatterns of useHealth StudyAdolescent girlsYear old youthRelative frequencyUnweighted frequenciesCigarettesOlder youthUse patternsPopulation Assessment
2019
Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial
Krishnan-Sarin S, O’Malley S, Franco N, Cavallo DA, Tetrault JM, Shi J, Gueorguieva R, Pittman B, Krystal JH. Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial. Neuropsychopharmacology 2019, 45: 319-326. PMID: 31590179, PMCID: PMC6901445, DOI: 10.1038/s41386-019-0536-z.Peer-Reviewed Original ResearchConceptsAlcohol drinking behaviorFirst treatment periodTreatment periodNumber of drinksCrossover trialDrinking behaviorEfficacy of naltrexoneOpioid antagonist naltrexoneNMDA antagonist memantinePositive family historyDay treatment periodSelf-administration periodAlcohol-induced stimulationAd lib accessMemantine treatmentAntagonist naltrexoneOpioid systemFamily historyNTXPriming drinkMemantineNaltrexoneAlcohol cravingHeavy drinkersAlcohol dependence
2018
Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study
Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM. Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study. The Lancet Psychiatry 2018, 5: 739-746. PMID: 30099000, DOI: 10.1016/s2215-0366(18)30227-x.Peer-Reviewed Original ResearchConceptsMental health burdenCross-sectional studyHealth burdenExercise typeMental healthPhysical exerciseBehavioral Risk Factor Surveillance System surveyPast monthBody mass index categoriesEffective clinical targetsPrevention's Behavioral Risk Factor Surveillance System (BRFSS) surveysSelf-reported mental healthFrequency of exerciseSelf-reported physical healthFunction of exerciseMultiple sensitivity analysesPoor mental healthTerms of ageCause mortalityPrevious diagnosisPotential confoundersInterventional studyCardiovascular diseaseReduced riskIndex categories
2017
Trajectories of relapse in randomised, placebo-controlled trials of treatment discontinuation in major depressive disorder: an individual patient-level data meta-analysis
Gueorguieva R, Chekroud AM, Krystal JH. Trajectories of relapse in randomised, placebo-controlled trials of treatment discontinuation in major depressive disorder: an individual patient-level data meta-analysis. The Lancet Psychiatry 2017, 4: 230-237. PMID: 28189575, PMCID: PMC5340978, DOI: 10.1016/s2215-0366(17)30038-x.Peer-Reviewed Original ResearchConceptsActive medicationActive treatmentClinical trialsDepression severityHamilton Depression Rating Scale scoresDepression Rating Scale scoresClinical Global Impression scoresIndividual patient-level dataDouble-blind treatmentPlacebo-controlled trialPatterns of relapseGlobal Impression scoresIndividual patient dataPrevention of relapseTrajectory class membershipTreatment of depressionMajor depressive disorderRating Scale scoresPatient-level dataPost-traumatic stress disorderTreatment discontinuationAntidepressant treatmentClinical responseAlcohol Research CenterAntidepressant medication
2016
Correlated probit analysis of repeatedly measured ordinal and continuous outcomes with application to the Health and Retirement Study
Grigorova D, Gueorguieva R. Correlated probit analysis of repeatedly measured ordinal and continuous outcomes with application to the Health and Retirement Study. Statistics In Medicine 2016, 35: 4202-4225. PMID: 27222058, DOI: 10.1002/sim.6982.Peer-Reviewed Original Research
2013
Temporal patterns of adherence to medications and behavioral treatment and their relationship to patient characteristics and treatment response
Gueorguieva R, Wu R, Krystal JH, Donovan D, O'Malley SS. Temporal patterns of adherence to medications and behavioral treatment and their relationship to patient characteristics and treatment response. Addictive Behaviors 2013, 38: 2119-2127. PMID: 23435273, PMCID: PMC3595348, DOI: 10.1016/j.addbeh.2013.01.024.Peer-Reviewed Original ResearchConceptsPercent heavy drinking daysAdherence trajectoriesExcellent adherersPercent days abstinentPatient characteristicsMedication adherenceTreatment outcomesMedication adherence trajectoriesPatterns of treatmentHeavy drinking daysPatterns of adherenceExcellent medication adherenceLack of benefitTrajectories of adherenceIntervention main effectsActive medicationAdverse eventsPharmacologic treatmentHigher percent days abstinentTreatment adherenceTreatment modalitiesWorse outcomesTreatment responseDays abstinentDrinking days
2011
Trajectories of Depression Severity in Clinical Trials of Duloxetine: Insights Into Antidepressant and Placebo Responses
Gueorguieva R, Mallinckrodt C, Krystal JH. Trajectories of Depression Severity in Clinical Trials of Duloxetine: Insights Into Antidepressant and Placebo Responses. JAMA Psychiatry 2011, 68: 1227-1237. PMID: 22147842, PMCID: PMC3339151, DOI: 10.1001/archgenpsychiatry.2011.132.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsData Interpretation, StatisticalDepressive Disorder, MajorDouble-Blind MethodDuloxetine HydrochlorideFemaleHumansLinear ModelsMalePatient DropoutsPlacebo EffectPsychiatric Status Rating ScalesRandomized Controlled Trials as TopicSelective Serotonin Reuptake InhibitorsSeverity of Illness IndexThiophenesTreatment OutcomeConceptsSelective serotonin reuptake inhibitorsPlacebo-treated patientsComparator selective serotonin reuptake inhibitorsHAM-D scoresClinical trialsAntidepressant treatmentPlacebo responseMajor depressionDouble-blind clinical trialHigh placebo response rateSerotonergic antidepressant treatmentPlacebo response ratesSerotonin reuptake inhibitorsAntidepressant nonrespondersPlacebo armMost patientsAntidepressant respondersMedication risksReuptake inhibitorsSerotonergic antidepressantsResponder statusTreatment responseClinical trajectoriesDepression scoresDepression severity
2010
Differential changes in body mass index after retirement by occupation: hierarchical models
Gueorguieva R, Sindelar JL, Wu R, Gallo WT. Differential changes in body mass index after retirement by occupation: hierarchical models. International Journal Of Public Health 2010, 56: 111-116. PMID: 20625792, PMCID: PMC3154720, DOI: 10.1007/s00038-010-0166-z.Peer-Reviewed Original ResearchConceptsBMI trajectoriesBody mass indexBody mass index (BMI) patternsMass indexHealth habitsBlue-collar occupationsOlder individualsJob physical demandsOccupational classBlue-collar workersNational dataSignificant increaseDifferential changesWhite-collar occupationsPhysical demandsCollar workersSocioeconomic characteristics
2009
The Impact of Occupation on Self-Rated Health: Cross-Sectional and Longitudinal Evidence from the Health and Retirement Survey
Gueorguieva R, Sindelar JL, Falba TA, Fletcher JM, Keenan P, Wu R, Gallo WT. The Impact of Occupation on Self-Rated Health: Cross-Sectional and Longitudinal Evidence from the Health and Retirement Survey. The Journals Of Gerontology Series B 2009, 64B: 118-124. PMID: 19196689, PMCID: PMC2654983, DOI: 10.1093/geronb/gbn006.Peer-Reviewed Original ResearchConceptsSelf-reported healthOlder individualsSelf-reported health statusSignificant baseline differencesSelf-rated healthHealth habitsBaseline differencesOccupation-related differencesHealth statusHealth trajectoriesImpact of occupationKey covariatesStudy sampleSignificant differencesRetirement StudyHealthOccupational categoriesRetirement SurveyLongitudinal evidenceIndividual ageOccupational differencesIndividualsDifferences
2007
New Insights into the Efficacy of Naltrexone Based on Trajectory-Based Reanalyses of Two Negative Clinical Trials
Gueorguieva R, Wu R, Pittman B, Cramer J, Rosenheck RA, O’Malley S, Krystal JH. New Insights into the Efficacy of Naltrexone Based on Trajectory-Based Reanalyses of Two Negative Clinical Trials. Biological Psychiatry 2007, 61: 1290-1295. PMID: 17224132, PMCID: PMC1952242, DOI: 10.1016/j.biopsych.2006.09.038.Peer-Reviewed Original Research
2005
Control Group Bias in Randomized Atypical Antipsychotic Medication Trials for Schizophrenia
Woods SW, Gueorguieva RV, Baker CB, Makuch RW. Control Group Bias in Randomized Atypical Antipsychotic Medication Trials for Schizophrenia. JAMA Psychiatry 2005, 62: 961-970. PMID: 16143728, DOI: 10.1001/archpsyc.62.9.961.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAntipsychotic AgentsBrief Psychiatric Rating ScaleDouble-Blind MethodDrug Administration ScheduleFemaleHumansMalePlacebosPsychotic DisordersRandomized Controlled Trials as TopicResearch DesignSchizophreniaSchizophrenic PsychologySelection BiasSeverity of Illness IndexSex FactorsTreatment OutcomeConceptsBrief Psychiatric Rating ScalePlacebo-controlled trialPsychiatric Rating ScalePlacebo-controlled studyAtypical antipsychotic medicationsDose-controlled studyMedication trialsAntipsychotic medicationRating ScaleDouble-blind clinical trialNew atypical antipsychotic medicationsDose-controlled trialsTreatment completion ratesPlacebo control groupEnd point changePercentage of menDrug Administration databaseRandom effects analysisIll adultsMedication armClinical trialsNew medicationsNovel medicationsSame drugAverage age
1999
The Impact of Low Birth Weight, Perinatal Conditions, and Sociodemographic Factors on Educational Outcome in Kindergarten
Resnick M, Gueorguieva R, Carter R, Ariet M, Sun Y, Roth J, Bucciarelli R, Curran J, Mahan C. The Impact of Low Birth Weight, Perinatal Conditions, and Sociodemographic Factors on Educational Outcome in Kindergarten. Pediatrics 1999, 104: e74-e74. PMID: 10586008, DOI: 10.1542/peds.104.6.e74.Peer-Reviewed Original ResearchConceptsLow birth weightLong-term morbidityBirth weightSociodemographic factorsPerinatal factorsPerinatal conditionsRisk factorsMultivariate analysisAdverse perinatal conditionsStandardized eligibility criteriaTotal birth populationSociodemographic risk factorsOdds of placementGeneralized logistic regressionPrenatal careEducational outcome variablesSevere outcomesCongenital anomaliesEligibility criteriaGreater prevalenceBirth recordsReference categoryLogistic regressionBirth populationSociodemographic predictors
1997
Genetic Mapping of 20 Novel Expressed Sequence Tags from Midgestation Mouse Embryos Suggests Chromosomal Clustering
Tchernev V, Barbosa M, Detter J, Patel T, Achey K, Wakeland E, Gueorguieva R, Yang M, Gossler A, Kingsmore S. Genetic Mapping of 20 Novel Expressed Sequence Tags from Midgestation Mouse Embryos Suggests Chromosomal Clustering. Genomics 1997, 40: 170-174. PMID: 9070936, DOI: 10.1006/geno.1996.4564.Peer-Reviewed Original ResearchConceptsGenetic mappingMammalian embryonic developmentMouse embryo libraryEmbryonic expression patternCharacterization of genesMouse Chr 14End sequence analysisMidgestation mouse embryosPotential regulatory functionsDistribution of genesMammalian embryogenesisMouse autosomesChromosomal clusteringDevelopmental mutationsGenetic colocalizationSequence tagsMouse genomeCDNA clonesEmbryonic developmentMouse embryosExpression patternsRelevant genesRegulatory functionsDifferentiation processChr 14