Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis
Radhakrishnan R, Pries LK, Erzin G, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Rutten BPF, van Os J, Guloksuz S. Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis. Psychological Medicine 2022, 53: 5551-5557. PMID: 36093677, PMCID: PMC10482707, DOI: 10.1017/s0033291722002756.Peer-Reviewed Original ResearchConceptsAnxiety/depressive symptomsDepressive symptomsCannabis usePE incidencePsychotic experiencesFirst longitudinal cohort studyNetherlands Mental Health SurveyLongitudinal cohort studyMental Health SurveyRole of cannabisBidirectional relationshipCohort studyHealth SurveyIncidence studyAffective symptomsSymptomsCannabisEducation statusLongitudinal studyPsychosisIncidenceAnxietyTemporal relationshipMediation analysisFurther supportImpact of Cannabis Use, Substance Use Disorders, and Psychiatric Diagnoses on COVID-19 Outcomes: A Retrospective Cohort Study.
Ramakrishnan D, Sureshanand S, Pittman B, Radhakrishnan R. Impact of Cannabis Use, Substance Use Disorders, and Psychiatric Diagnoses on COVID-19 Outcomes: A Retrospective Cohort Study. The Journal Of Clinical Psychiatry 2022, 83 PMID: 36044600, DOI: 10.4088/jcp.21m14332.Peer-Reviewed Original ResearchConceptsCOVID-19 outcomesSubstance use disordersOpioid use disorderCOVID-19 patientsAlcohol use disorderRetrospective cohort studyVentilatory supportICU admissionUse disordersHospital admissionPsychiatric diagnosisCohort studyIntensive care unit admissionCOVID-19 positive patientsCare unit admissionLength of hospitalizationLarge health care systemMultivariable logistic regressionHigh-risk groupNumber of hospitalizationsBenzodiazepine use disorderCannabis use disorderUrine toxicology reportsElectronic medical recordsCocaine use disorder