2024
Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice
Islam R, White J, Arefin T, Mehta S, Liu X, Polis B, Giuliano L, Ahmed S, Bowers C, Zhang J, Kaffman A. Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice. Biology Of Sex Differences 2024, 15: 39. PMID: 38715106, PMCID: PMC11075329, DOI: 10.1186/s13293-024-00616-0.Peer-Reviewed Original ResearchConceptsLateral entorhinal cortexContextual fear conditioningDorsal hippocampusHippocampal developmentSex differencesFear conditioningEarly adversityLimited beddingSevere deficitsModel of early adversitySex-specific deficitsReelin-positive neuronsPerforant pathwayReelin-positive cellsDiffusion magnetic resonance imagingEx vivo diffusion magnetic resonance imagingContextual freezingContextual memoryAdolescent miceHippocampal functionLife adversityEntorhinal cortexHippocampusDeficitsAdolescent males
2021
Anredera cordifolia extract enhances learning and memory in senescence-accelerated mouse-prone 8 (SAMP8) mice
Sumiyoshi E, Hashimoto M, Hossain S, Matsuzaki K, Islam R, Tanabe Y, Maruyama K, Kajima K, Arai H, Ohizumi Y, Shido O. Anredera cordifolia extract enhances learning and memory in senescence-accelerated mouse-prone 8 (SAMP8) mice. Food & Function 2021, 12: 3992-4004. PMID: 33977955, DOI: 10.1039/d0fo03272g.Peer-Reviewed Original ResearchConceptsBrain-derived neurotropic factorPlasticity-related proteinsBlood biochemistry parametersMemory deficitsSynaptic plasticity-related proteinsBiochemistry parametersNovel object recognition taskMorris water maze taskAC extractNoticeable side effectsWater maze taskNegative control groupAge-related memory deficitsAge-related declineHippocampal levelsNeurotropic factorOral administrationCognition declinePathological changesMouse modelSide effectsBehavioral testingNOR taskControl groupMemory impairment