2021
Anredera cordifolia extract enhances learning and memory in senescence-accelerated mouse-prone 8 (SAMP8) mice
Sumiyoshi E, Hashimoto M, Hossain S, Matsuzaki K, Islam R, Tanabe Y, Maruyama K, Kajima K, Arai H, Ohizumi Y, Shido O. Anredera cordifolia extract enhances learning and memory in senescence-accelerated mouse-prone 8 (SAMP8) mice. Food & Function 2021, 12: 3992-4004. PMID: 33977955, DOI: 10.1039/d0fo03272g.Peer-Reviewed Original ResearchConceptsBrain-derived neurotropic factorPlasticity-related proteinsBlood biochemistry parametersMemory deficitsSynaptic plasticity-related proteinsBiochemistry parametersNovel object recognition taskMorris water maze taskAC extractNoticeable side effectsWater maze taskNegative control groupAge-related memory deficitsAge-related declineHippocampal levelsNeurotropic factorOral administrationCognition declinePathological changesMouse modelSide effectsBehavioral testingNOR taskControl groupMemory impairment
2017
Direct exposure to mild heat promotes proliferation and neuronal differentiation of neural stem/progenitor cells in vitro
Hossain E, Matsuzaki K, Katakura M, Sugimoto N, Al Mamun AA, Islam R, Hashimoto M, Shido O. Direct exposure to mild heat promotes proliferation and neuronal differentiation of neural stem/progenitor cells in vitro. PLOS ONE 2017, 12: e0190356. PMID: 29287093, PMCID: PMC5747471, DOI: 10.1371/journal.pone.0190356.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain-Derived Neurotrophic FactorCell DifferentiationCell ProliferationCells, CulturedChromonesCREB-Binding ProteinHeat-Shock ProteinsHot TemperatureMorpholinesNeural Stem CellsNeuronsPhosphorylationProto-Oncogene Proteins c-aktRatsReactive Oxygen SpeciesReal-Time Polymerase Chain ReactionConceptsNSC/NPC proliferationBrain-derived neurotrophic factorNSCs/NPCsNeural stem/progenitor cellsStem/progenitor cellsNeurosphere diameterMild heat exposureNPC proliferationMRNA expressionHeat exposureHeat shock proteinsNeuronal differentiationBDNF mRNA expressionProgenitor cellsEffective therapeutic strategyHeat-acclimated ratsCAMP response element-binding proteinResponse element-binding proteinReactive oxygen species levelsHeat acclimationAkt phosphorylation levelsForebrain cortexProportion of cellsEnhanced neurogenesisNeurotrophic factor