Plasmid-Mediated Sulfamethoxazole Resistance Encoded by the sul2 Gene in the Multidrug-Resistant Shigella flexneri 2a Isolated from Patients with Acute Diarrhea in Dhaka, Bangladesh
Iqbal MS, Rahman M, Islam R, Banik A, Amin MB, Akter F, Talukder KA. Plasmid-Mediated Sulfamethoxazole Resistance Encoded by the sul2 Gene in the Multidrug-Resistant Shigella flexneri 2a Isolated from Patients with Acute Diarrhea in Dhaka, Bangladesh. PLOS ONE 2014, 9: e85338. PMID: 24416393, PMCID: PMC3887042, DOI: 10.1371/journal.pone.0085338.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnti-Bacterial AgentsBacterial ProteinsBacterial Typing TechniquesBangladeshCarrier ProteinsDiarrheaDrug Resistance, Multiple, BacterialDysentery, BacillaryElectrophoresis, Gel, Pulsed-FieldGene ExpressionHumansPlasmidsShigella flexneriSulfamethoxazoleTrimethoprim, Sulfamethoxazole Drug CombinationConceptsShigella flexneri 2aFlexneri 2aMDa plasmidSulfamethoxazole resistanceEffective clinical managementS. flexneri 2aAcute diarrheaClinical managementPulsed-field gel electrophoresis analysisSul2 geneClinical isolatesAntimicrobial susceptibilityDrug resistanceEnteric pathogensClinical strainsPlasmid-cured derivativeMicrobiology laboratoryPlasmid profilingResistance determinantsFood microbiology laboratoriesPCR analysisHeterogeneous patternInvolvementDiarrheaPatients