Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats
Matsuzaki K, Sugimoto N, Hossain S, Islam R, Sumiyoshi E, Hashimoto M, Kishi H, Shido O. Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats. Food & Function 2024, 15: 5579-5595. PMID: 38713055, DOI: 10.1039/d4fo00683f.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderVesicular monoamine transporter-2Brain-derived neurotrophic factorPrefrontal cortexDopamine transporterCognitive functionDopamine concentrationTyrosine hydroxylaseADHD animal modelWistar-Kyoto ratsBrain-derived neurotrophic factor levelsWorking memory deficitsTB administrationY-maze taskCortex of spontaneously hypertensive ratsFrontal cortex of SHRADHD-like behaviorsOpen field testPotential adjunctive treatmentStroke-prone spontaneously hypertensive ratsWorking memoryAttention-deficit/hyperactivityMemory deficitsCognitive deficitsFrontal cortex