2021
Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway
Al Mamun A, Matsuzaki K, Islam R, Hossain S, Hossain ME, Katakura M, Arai H, Shido O, Hashimoto M. Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway. Neurochemical Research 2021, 47: 933-951. PMID: 34855048, DOI: 10.1007/s11064-021-03495-8.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorChronic administrationCAMP response element-binding proteinAdult ratsHippocampal neurogenesisCREB/brain-derived neurotrophic factorBDNF Signaling PathwayChronic oral administrationAdult hippocampal neurogenesisNumber of bromodeoxyuridineEffect of TQCultured neural stem/progenitor cellsMature neuronal markersNeural stem/progenitor cellsNigella sativa LinnStem/progenitor cellsProfound beneficial effectsRats ViaWestern blot analysisBDNF pathwayProportion of cellsTQ treatmentAdult neurogenesisNeurotrophic factorDentate gyrus
2017
Direct exposure to mild heat promotes proliferation and neuronal differentiation of neural stem/progenitor cells in vitro
Hossain E, Matsuzaki K, Katakura M, Sugimoto N, Al Mamun AA, Islam R, Hashimoto M, Shido O. Direct exposure to mild heat promotes proliferation and neuronal differentiation of neural stem/progenitor cells in vitro. PLOS ONE 2017, 12: e0190356. PMID: 29287093, PMCID: PMC5747471, DOI: 10.1371/journal.pone.0190356.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain-Derived Neurotrophic FactorCell DifferentiationCell ProliferationCells, CulturedChromonesCREB-Binding ProteinHeat-Shock ProteinsHot TemperatureMorpholinesNeural Stem CellsNeuronsPhosphorylationProto-Oncogene Proteins c-aktRatsReactive Oxygen SpeciesReal-Time Polymerase Chain ReactionConceptsNSC/NPC proliferationBrain-derived neurotrophic factorNSCs/NPCsNeural stem/progenitor cellsStem/progenitor cellsNeurosphere diameterMild heat exposureNPC proliferationMRNA expressionHeat exposureHeat shock proteinsNeuronal differentiationBDNF mRNA expressionProgenitor cellsEffective therapeutic strategyHeat-acclimated ratsCAMP response element-binding proteinResponse element-binding proteinReactive oxygen species levelsHeat acclimationAkt phosphorylation levelsForebrain cortexProportion of cellsEnhanced neurogenesisNeurotrophic factor