2024
Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats
Matsuzaki K, Sugimoto N, Hossain S, Islam R, Sumiyoshi E, Hashimoto M, Kishi H, Shido O. Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats. Food & Function 2024, 15: 5579-5595. PMID: 38713055, DOI: 10.1039/d4fo00683f.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderVesicular monoamine transporter-2Brain-derived neurotrophic factorPrefrontal cortexDopamine transporterCognitive functionDopamine concentrationTyrosine hydroxylaseADHD animal modelWistar-Kyoto ratsBrain-derived neurotrophic factor levelsWorking memory deficitsTB administrationY-maze taskCortex of spontaneously hypertensive ratsFrontal cortex of SHRADHD-like behaviorsOpen field testPotential adjunctive treatmentStroke-prone spontaneously hypertensive ratsWorking memoryAttention-deficit/hyperactivityMemory deficitsCognitive deficitsFrontal cortex
2021
Anredera cordifolia extract enhances learning and memory in senescence-accelerated mouse-prone 8 (SAMP8) mice
Sumiyoshi E, Hashimoto M, Hossain S, Matsuzaki K, Islam R, Tanabe Y, Maruyama K, Kajima K, Arai H, Ohizumi Y, Shido O. Anredera cordifolia extract enhances learning and memory in senescence-accelerated mouse-prone 8 (SAMP8) mice. Food & Function 2021, 12: 3992-4004. PMID: 33977955, DOI: 10.1039/d0fo03272g.Peer-Reviewed Original ResearchConceptsBrain-derived neurotropic factorPlasticity-related proteinsBlood biochemistry parametersMemory deficitsSynaptic plasticity-related proteinsBiochemistry parametersNovel object recognition taskMorris water maze taskAC extractNoticeable side effectsWater maze taskNegative control groupAge-related memory deficitsAge-related declineHippocampal levelsNeurotropic factorOral administrationCognition declinePathological changesMouse modelSide effectsBehavioral testingNOR taskControl groupMemory impairment