2021
Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway
Al Mamun A, Matsuzaki K, Islam R, Hossain S, Hossain ME, Katakura M, Arai H, Shido O, Hashimoto M. Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway. Neurochemical Research 2021, 47: 933-951. PMID: 34855048, DOI: 10.1007/s11064-021-03495-8.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorChronic administrationCAMP response element-binding proteinAdult ratsHippocampal neurogenesisCREB/brain-derived neurotrophic factorBDNF Signaling PathwayChronic oral administrationAdult hippocampal neurogenesisNumber of bromodeoxyuridineEffect of TQCultured neural stem/progenitor cellsMature neuronal markersNeural stem/progenitor cellsNigella sativa LinnStem/progenitor cellsProfound beneficial effectsRats ViaWestern blot analysisBDNF pathwayProportion of cellsTQ treatmentAdult neurogenesisNeurotrophic factorDentate gyrus
2019
Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats
Islam R, Matsuzaki K, Sumiyoshi E, Hossain E, Hashimoto M, Katakura M, Sugimoto N, Shido O. Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats. Nutrients 2019, 11: 888. PMID: 31010016, PMCID: PMC6520707, DOI: 10.3390/nu11040888.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain-Derived Neurotrophic FactorCacaoCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP Response Element-Binding ProteinDietary SupplementsMaleMaze LearningMemory, Short-TermPhosphorylationPhytotherapyPlant ExtractsRats, WistarRNA, MessengerSignal TransductionTheobromineConceptsCREB/BDNF pathwayBrain-derived neurotropic factorMedial prefrontal cortexCAMP response element-binding proteinBDNF pathwayTB ratsCN ratsNovel object recognition testPhosphorylated cAMP response element-binding proteinY-maze testMale Wistar ratsEffect of theobromineObject recognition testRadial arm maze taskEnzyme-linked immunosorbentPrimary methylxanthineBDNF levelsBDNF proteinNeurotropic factorNormal dietReal-time PCRWistar ratsDifferent brain processesElement-binding proteinP-CaMKII