Rafiad Islam, PhD
Associate Research ScientistDownloadHi-Res Photo
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Appointments
Neurology
Primary
Contact Info
Yale School of Medicine
300 George St. 3rd floor, Suite 353, Rafiad Islam (Hafler Lab)
New Haven, CT 06511
United States
About
Titles
Associate Research Scientist
Biography
An experienced neuroscientist with expertise in behavioral neuroscience and developmental neurobiology, now focusing on the immunology of Parkinson's disease. Skilled in rodent neurosurgery and behavioral paradigms, with a proven track record of strong leadership, innovative thinking, and problem-solving in both scientific and non-scientific contexts. Passionate about developing new ideas and solutions.
Appointments
Education & Training
- PhD
- Shimane University, Neuroscience (2020)
- MSc
- University Of Dhaka, Department Of biochemistry and Molecular Biology (2011)
- BSc
- University Of Dhaka, Department of Biochemistry and Molecular Biology (2009)
Research
Overview
Medical Research Interests
Autoimmune Diseases; Behavior and Behavior Mechanisms; Child Psychiatry; Gene Expression Regulation, Developmental; Memory; Memory and Learning Tests; Multiple Sclerosis; Neurology; Parkinson Disease; Psychology, Developmental
Public Health Interests
Antimicrobial Resistance; Behavioral Health
ORCID
0000-0001-5039-6240
Research at a Glance
Yale Co-Authors
Frequent collaborators of Rafiad Islam's published research.
Publications Timeline
A big-picture view of Rafiad Islam's research output by year.
Research Interests
Research topics Rafiad Islam is interested in exploring.
Arie Kaffman, MD, PhD
Basavaraju Sanganahalli, PhD
D. S. Fahmeed Hyder, PhD
Sahabuddin Ahmed
Sameet Mehta, PhD
Thomas Biederer, PhD
14Publications
197Citations
Publications
2024
Transient impairment in microglial function causes sex-specific deficits in synaptic maturity and hippocampal function in mice exposed to early adversity
Ahmed S, Polis B, Jamwal S, Sanganahalli B, MacDowell Kaswan Z, Islam R, Kim D, Bowers C, Giuliano L, Biederer T, Hyder F, Kaffman A. Transient impairment in microglial function causes sex-specific deficits in synaptic maturity and hippocampal function in mice exposed to early adversity. Brain Behavior And Immunity 2024, 122: 95-109. PMID: 39134183, PMCID: PMC11402597, DOI: 10.1016/j.bbi.2024.08.010.Peer-Reviewed Original ResearchConceptsEarly-life adversityModel of early-life adversityContextual fear conditioningLimited beddingFear conditioningSynaptic engulfmentLB miceSynaptic pruningSex-specific deficitsHippocampus of maleSex-specific effectsHippocampal deficitsAdolescent miceHippocampal functionEarly adversityChemogenetic activationSynaptic connectionsBehavioral aberrationsPotential compensatory mechanismsSynaptic abnormalitiesHippocampusAblation of microgliaRodent hippocampusDeficitsWeeks of lifeTheobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats
Matsuzaki K, Sugimoto N, Hossain S, Islam R, Sumiyoshi E, Hashimoto M, Kishi H, Shido O. Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats. Food & Function 2024, 15: 5579-5595. PMID: 38713055, DOI: 10.1039/d4fo00683f.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAttention-deficit/hyperactivity disorderVesicular monoamine transporter-2Brain-derived neurotrophic factorPrefrontal cortexDopamine transporterCognitive functionDopamine concentrationTyrosine hydroxylaseADHD animal modelWistar-Kyoto ratsBrain-derived neurotrophic factor levelsWorking memory deficitsTB administrationY-maze taskCortex of spontaneously hypertensive ratsFrontal cortex of SHRADHD-like behaviorsOpen field testPotential adjunctive treatmentStroke-prone spontaneously hypertensive ratsWorking memoryAttention-deficit/hyperactivityMemory deficitsCognitive deficitsFrontal cortexEarly adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice
Islam R, White J, Arefin T, Mehta S, Liu X, Polis B, Giuliano L, Ahmed S, Bowers C, Zhang J, Kaffman A. Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice. Biology Of Sex Differences 2024, 15: 39. PMID: 38715106, PMCID: PMC11075329, DOI: 10.1186/s13293-024-00616-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLateral entorhinal cortexContextual fear conditioningDorsal hippocampusHippocampal developmentSex differencesFear conditioningEarly adversityLimited beddingSevere deficitsModel of early adversitySex-specific deficitsReelin-positive neuronsPerforant pathwayReelin-positive cellsDiffusion magnetic resonance imagingEx vivo diffusion magnetic resonance imagingContextual freezingContextual memoryAdolescent miceHippocampal functionLife adversityEntorhinal cortexHippocampusDeficitsAdolescent males
2023
EARLY ADVERSITY CAUSES SEX-SPECIFIC DEFICITS IN ENTORHINAL-DORSAL HIPPOCAMPUS CONNECTIVITY AND CONTEXTUAL FEAR CONDITIONING IN ADOLESCENT MICE
Islam R, Arefin T, White J, Polis B, Ahmed S, Liu X, Zhang J, Kaffman A. EARLY ADVERSITY CAUSES SEX-SPECIFIC DEFICITS IN ENTORHINAL-DORSAL HIPPOCAMPUS CONNECTIVITY AND CONTEXTUAL FEAR CONDITIONING IN ADOLESCENT MICE. IBRO Neuroscience Reports 2023, 15: s103-s104. DOI: 10.1016/j.ibneur.2023.08.089.Peer-Reviewed Original Research
2022
Early life stress impairs synaptic pruning in the developing hippocampus
Dayananda KK, Ahmed S, Wang D, Polis B, Islam R, Kaffman A. Early life stress impairs synaptic pruning in the developing hippocampus. Brain Behavior And Immunity 2022, 107: 16-31. PMID: 36174883, PMCID: PMC10497209, DOI: 10.1016/j.bbi.2022.09.014.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSynaptic pruningMicroglial ramificationHippocampal functionAbnormal hippocampal functionCA1 pyramidal neuronsExpression of TREM2Increased spine densityRamification of microgliaEarly life adversityNormal hippocampal functionSynaptic engulfmentClinical outcomesPyramidal neuronsSpine densityFemale miceHippocampal stimulationSevere formHippocampal developmentPhagocytic activitySevere impairmentEx vivoLife adversityThird weekEarly adversityMice雲南百薬抽出エキス摂取が学習・記憶障害を呈する老化促進モデルマウス(SAMP8)の認知機能に及ぼす効果
愛里 住, 道男 橋, Shahdat H, 健太郎 松, Rafiad I, 洋子 田, 浩司 丸, 康二 嘉, 啓行 荒, 康 大, 治 紫. 雲南百薬抽出エキス摂取が学習・記憶障害を呈する老化促進モデルマウス(SAMP8)の認知機能に及ぼす効果. Proceedings For Annual Meeting Of The Japanese Pharmacological Society 2022, 95: 1-p-064. DOI: 10.1254/jpssuppl.95.0_1-p-064.Peer-Reviewed Original Research
2021
Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway
Al Mamun A, Matsuzaki K, Islam R, Hossain S, Hossain ME, Katakura M, Arai H, Shido O, Hashimoto M. Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway. Neurochemical Research 2021, 47: 933-951. PMID: 34855048, DOI: 10.1007/s11064-021-03495-8.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsBrain-derived neurotrophic factorChronic administrationCAMP response element-binding proteinAdult ratsHippocampal neurogenesisCREB/brain-derived neurotrophic factorBDNF Signaling PathwayChronic oral administrationAdult hippocampal neurogenesisNumber of bromodeoxyuridineEffect of TQCultured neural stem/progenitor cellsMature neuronal markersNeural stem/progenitor cellsNigella sativa LinnStem/progenitor cellsProfound beneficial effectsRats ViaWestern blot analysisBDNF pathwayProportion of cellsTQ treatmentAdult neurogenesisNeurotrophic factorDentate gyrusAnredera cordifolia extract enhances learning and memory in senescence-accelerated mouse-prone 8 (SAMP8) mice
Sumiyoshi E, Hashimoto M, Hossain S, Matsuzaki K, Islam R, Tanabe Y, Maruyama K, Kajima K, Arai H, Ohizumi Y, Shido O. Anredera cordifolia extract enhances learning and memory in senescence-accelerated mouse-prone 8 (SAMP8) mice. Food & Function 2021, 12: 3992-4004. PMID: 33977955, DOI: 10.1039/d0fo03272g.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsBrain-derived neurotropic factorPlasticity-related proteinsBlood biochemistry parametersMemory deficitsSynaptic plasticity-related proteinsBiochemistry parametersNovel object recognition taskMorris water maze taskAC extractNoticeable side effectsWater maze taskNegative control groupAge-related memory deficitsAge-related declineHippocampal levelsNeurotropic factorOral administrationCognition declinePathological changesMouse modelSide effectsBehavioral testingNOR taskControl groupMemory impairmentWhite-Matter Repair as a Novel Therapeutic Target for Early Adversity
Islam R, Kaffman A. White-Matter Repair as a Novel Therapeutic Target for Early Adversity. Frontiers In Neuroscience 2021, 15: 657693. PMID: 33897364, PMCID: PMC8062784, DOI: 10.3389/fnins.2021.657693.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMyelin developmentWhite matter repairNovel therapeutic targetPre-clinical workNovel therapeutic interventionsNon-human primatesNew agentsTherapeutic targetAnimal modelsTherapeutic interventionsTranslational researchEarly adversityRecent mechanistic studiesMolecular mechanismsRodentsDiverse mammalian species
2020
Salivary Immunoglobulin A Secretion and Polymeric Ig Receptor Expression in the Submandibular Glands Are Enhanced in Heat-Acclimated Rats
Matsuzaki K, Sugimoto N, Islam R, Hossain E, Sumiyoshi E, Katakura M, Shido O. Salivary Immunoglobulin A Secretion and Polymeric Ig Receptor Expression in the Submandibular Glands Are Enhanced in Heat-Acclimated Rats. International Journal Of Molecular Sciences 2020, 21: 815. PMID: 32012687, PMCID: PMC7037029, DOI: 10.3390/ijms21030815.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSalivary IgA secretionIgA secretionHeat-acclimated ratsSubmandibular glandIgA flow rateImmunoglobulin A (IgA) secretionMucosal IgA secretionSalivary IgA concentrationMale Wistar ratsSalivary immunoglobulin AHeat acclimationPolymeric Ig receptor expressionPlasma cytokinesCN ratsMucosal immunityOral immunityIL-6IgA concentrationsReceptor expressionImmunoglobulin AWistar ratsSalivary functionHE groupChronic exposurePIgR expression
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Mailing Address
Yale School of Medicine
300 George St. 3rd floor, Suite 353, Rafiad Islam (Hafler Lab)
New Haven, CT 06511
United States