The association between the amino acid transporter LAT1, tumor immunometabolic and proliferative features and menopausal status in breast cancer
Ramshankar G, Liu R, Perry R. The association between the amino acid transporter LAT1, tumor immunometabolic and proliferative features and menopausal status in breast cancer. PLOS ONE 2023, 18: e0292678. PMID: 37819900, PMCID: PMC10566702, DOI: 10.1371/journal.pone.0292678.Peer-Reviewed Original ResearchConceptsL-type amino acid transporter 1Menopausal statusPrognostic effectLAT1 expressionBreast cancerTumor proliferationAmino acid transporter LAT1Immune cell infiltrationHigh LAT1 expressionAmino acid transporter 1Worse patient outcomesKaplan-Meier modelBreast cancer prognosisPatient survival probabilityPositron emission tomography-computed tomography (PET-CT) imagesSpecific essential amino acidsClinical factorsClinical parametersCell infiltrationPatient outcomesSystemic metabolismCancer prognosisBody compositionProliferative featuresCancer typesThe impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors
Liu R, Ospanova S, Perry R. The impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors. PLOS ONE 2023, 18: e0281252. PMID: 36735704, PMCID: PMC9897541, DOI: 10.1371/journal.pone.0281252.Peer-Reviewed Original ResearchConceptsBreast cancer prognosisBreast cancerFatty acid metabolismCancer prognosisCarnitine palmitoyltransferase 1 expressionHigh-risk breast cancerPre-menopausal patientsAcid metabolismPatient survival probabilityPositron emission tomography-computed tomography (PET-CT) imagesFatty acid oxidationMenopausal statusAnthropometric factorsPathogenic factorsCPT1A expressionRate-limiting enzymeObesityProtective relationshipCancerSurvival probabilityCancer Imaging ArchivePotential rolePatientsPrognosisAcid oxidation