Featured Publications
Implantable Cardioverter Defibrillator Lead Survival in Athletic Patients
Link MS, Sullivan RM, Olshansky B, Cannom D, Berul CI, Hauser RG, Heidbuchel H, Jordaens L, Krahn AD, Morgan J, Patton KK, Saarel EV, Wilkoff BL, Li F, Dziura J, Brandt C, Barth C, Lampert R. Implantable Cardioverter Defibrillator Lead Survival in Athletic Patients. Circulation Arrhythmia And Electrophysiology 2021, 14: e009344. PMID: 33724879, DOI: 10.1161/circep.120.009344.Peer-Reviewed Original ResearchCompetitive athletes with implantable cardioverter–defibrillators—How to program? Data from the Implantable Cardioverter–Defibrillator Sports Registry
Olshansky B, Atteya G, Cannom D, Heidbuchel H, Saarel EV, Anfinsen OG, Cheng A, Gold MR, Müssigbrodt A, Patton KK, Saxon LA, Wilkoff BL, Willems R, Dziura J, Li F, Brandt C, Simone L, Wilhelm M, Lampert R. Competitive athletes with implantable cardioverter–defibrillators—How to program? Data from the Implantable Cardioverter–Defibrillator Sports Registry. Heart Rhythm 2018, 16: 581-587. PMID: 30389442, DOI: 10.1016/j.hrthm.2018.10.032.Peer-Reviewed Original ResearchConceptsHigh-rate cutoffTransient lossICD shocksRisk of totalInappropriate ICD shocksLonger detection intervalsDual-chamber devicesRisk of shockAppropriate shocksVentricular tachycardiaInappropriate shocksInternational registrySudden deathCompetitive athletesRate cutoffICDOccurrence of shockPatientsAthletesRegistryRiskLonger detectionDeathDetection rateTotal shocks
2024
Stress-Induced Autonomic Dysfunction is Associated With Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Artery Disease
Osei J, Vaccarino V, Wang M, Shah A, Lampert R, Li L, Ko Y, Pearce B, Kutner M, Garcia E, Piccinelli M, Raggi P, Bremner J, Quyyumi A, Sun Y, Ahmed H, Haddad G, Daaboul O, Roberts T, Stefanos L, Correia L, Shah A. Stress-Induced Autonomic Dysfunction is Associated With Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Artery Disease. Circulation Cardiovascular Imaging 2024, 17: e016596. PMID: 38868952, PMCID: PMC11187646, DOI: 10.1161/circimaging.124.016596.Peer-Reviewed Original ResearchConceptsMental stress-induced myocardial ischemiaLow heart rate variabilityAssociated with MSIMICoronary artery diseaseAssociated with higher oddsStable coronary artery diseaseStress-induced myocardial ischemiaAutonomic dysfunctionLow-frequency heart rate variabilityArtery diseaseHeart rate variabilityHigher oddsHigher heart rate variabilityResponse to stressIndicator of autonomic dysfunctionMyocardial ischemiaSpeech stressorAssociated with adverse cardiovascular outcomesMultivariate logistic regression modelAssociation of autonomic dysfunctionAdverse cardiovascular outcomesLogistic regression modelsBlack participantsHolter monitoringClinical factorsHousehold food insecurity is associated with greater autonomic dysfunction testing score in Latinos with type 2 diabetes
Bermúdez-Millán A, Feinn R, Lampert R, Pérez-Escamilla R, Segura-Pérez S, Wagner J. Household food insecurity is associated with greater autonomic dysfunction testing score in Latinos with type 2 diabetes. PLOS ONE 2024, 19: e0297681. PMID: 38394186, PMCID: PMC10889858, DOI: 10.1371/journal.pone.0297681.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureAutonomic function testsAutonomic nervous systemType 2 diabetesHousehold food insecurityDysfunction indexFunction testsHigher diastolic blood pressureAverage diastolic blood pressureAssociated with ANS dysfunctionU.S. Household Food Security Survey ModuleHousehold Food Security Survey ModuleFood Security Survey ModuleBaseline supineFood insecuritySustained handgripBenefit health outcomesLow-income LatinosANS dysfunctionScore 0Improve food accessHandgrip testInsulin useBlood pressureHeart rate variability
2013
Safety of Sports for Athletes With Implantable Cardioverter-Defibrillators
Lampert R, Olshansky B, Heidbuchel H, Lawless C, Saarel E, Ackerman M, Calkins H, Estes NA, Link MS, Maron BJ, Marcus F, Scheinman M, Wilkoff BL, Zipes DP, Berul CI, Cheng A, Law I, Loomis M, Barth C, Brandt C, Dziura J, Li F, Cannom D. Safety of Sports for Athletes With Implantable Cardioverter-Defibrillators. Circulation 2013, 127: 2021-2030. PMID: 23690453, DOI: 10.1161/circulationaha.112.000447.Peer-Reviewed Original ResearchConceptsPhysical activityImplantable cardioverter defibrillator patientsSafety of sportsCardioverter-defibrillator patientsVentricular arrhythmia episodesImplantable cardioverter defibrillatorSports participationHigh-risk sportsAppropriate shocksMedian ageClinical outcomesVentricular arrhythmiasInformed physicianMedical recordsClinical dataLead malfunctionCardioverter defibrillatorCommon sportsArrhythmia episodesPatient decisionCompetitive athletesPrimary endArrhythmiasICDPhone interviewsSafety of Pacemaker Implantation in Nonagenarians
Mandawat A, Curtis JP, Mandawat A, Njike VY, Lampert R. Safety of Pacemaker Implantation in Nonagenarians. Circulation 2013, 127: 1453-1465. PMID: 23513066, DOI: 10.1161/circulationaha.113.001434.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overArrhythmias, CardiacComorbidityCross-Sectional StudiesFemaleHealth Care CostsHospital MortalityHumansLength of StayLinear ModelsLogistic ModelsMaleMultivariate AnalysisOutcome and Process Assessment, Health CarePacemaker, ArtificialPredictive Value of TestsUnited StatesConceptsLength of stayYears of ageSevere comorbiditiesPacemaker implantationUtilization Project Nationwide Inpatient SampleInitial pacemaker implantationCase-mix variationMantel-Haenszel testStepwise linear regression modelHospital mortalityUnadjusted mortalityComplication rateMultivariable analysisUnadjusted outcomesInpatient SampleHealthcare costsPatientsComorbiditiesHierarchical logistic modelsStayNonagenariansMortalityAgeOutcomesComplications
2012
Patients’ Attitudes and Perceptions of Implantable Cardioverter‐Defibrillators: Potential Barriers to Appropriate Primary Prophylaxis
YUHAS J, MATTOCKS K, GRAVELIN L, REMETZ M, FOLEY J, FAZIO R, LAMPERT R. Patients’ Attitudes and Perceptions of Implantable Cardioverter‐Defibrillators: Potential Barriers to Appropriate Primary Prophylaxis. Pacing And Clinical Electrophysiology 2012, 35: 1179-1187. PMID: 22897624, DOI: 10.1111/j.1540-8159.2012.03497.x.Peer-Reviewed Original ResearchConceptsSudden cardiac deathICD referralPrimary prophylaxisPatients' attitudesPotential patient-related barriersPrimary prevention candidatesOutpatient cardiology clinicPatient-related barriersRecords of patientsImplantable cardioverter defibrillatorLife-prolonging interventionsCardiac deathEjection fractionPhysician recommendationSurgical riskCardiology clinicICD placementOpen-ended interview guideCardioverter defibrillatorLifestyle changesICD prophylaxisPatientsProphylaxisReferralICDImpact of a Recent Lead Recall on Utilization of Implantable Cardioverter Defibrillators: Data from the NCDR ICD Registry™
BHATT P, CURTIS J, WANG Y, LAMPERT R. Impact of a Recent Lead Recall on Utilization of Implantable Cardioverter Defibrillators: Data from the NCDR ICD Registry™. Journal Of Cardiovascular Electrophysiology 2012, 23: 861-865. PMID: 22452744, DOI: 10.1111/j.1540-8167.2012.02310.x.Peer-Reviewed Original ResearchAgedAged, 80 and overDeath, Sudden, CardiacDefibrillators, ImplantableElectric CountershockFemaleHumansMaleMedical Device RecallsMiddle AgedPractice Guidelines as TopicPractice Patterns, Physicians'Primary PreventionProsthesis DesignProsthesis FailureRegistriesRisk AssessmentRisk FactorsTime FactorsUnited States
2009
Anger-Induced T-Wave Alternans Predicts Future Ventricular Arrhythmias in Patients With Implantable Cardioverter-Defibrillators
Lampert R, Shusterman V, Burg M, McPherson C, Batsford W, Goldberg A, Soufer R. Anger-Induced T-Wave Alternans Predicts Future Ventricular Arrhythmias in Patients With Implantable Cardioverter-Defibrillators. Journal Of The American College Of Cardiology 2009, 53: 774-778. PMID: 19245968, PMCID: PMC3979284, DOI: 10.1016/j.jacc.2008.10.053.Peer-Reviewed Original ResearchConceptsVentricular tachycardia/ventricular fibrillationFuture ventricular arrhythmiasT-wave alternansVentricular arrhythmiasVentricular fibrillationSpontaneous ventricular tachycardia/ventricular fibrillationHigher TWAImplantable cardioverter defibrillatorEjection fractionHighest quartileTWA testingWide QRSClinical arrhythmiaAmbulatory electrocardiographyLowest quartileFuture arrhythmiasSudden deathCardioverter defibrillatorClinical roleMultivariable regressionPatientsArrhythmiasRepolarization instabilityStress protocolSignificant predictors
2007
Implantable Cardioverter‐Defibrillator Shocks Increase T‐Wave Alternans
LAMPERT R, SOUFER R, McPHERSON CA, BATSFORD WP, TIRADO S, EARLEY C, GOLDBERG A, SHUSTERMAN V. Implantable Cardioverter‐Defibrillator Shocks Increase T‐Wave Alternans. Journal Of Cardiovascular Electrophysiology 2007, 18: 512-517. PMID: 17428273, DOI: 10.1111/j.1540-8167.2007.00787.x.Peer-Reviewed Original ResearchConceptsRepolarization instabilityQRS duration changesImplantable defibrillator shocksAmbulatory ECG monitoringT-wave alternansNorepinephrine levelsCoronary diseaseICD shocksSympathetic stimulationVentricular arrhythmiasInduced arrhythmiasVentricular arrhythmogenesisDefibrillator shocksQRS durationQT intervalSedated stateAdequate preClinical implicationsDefibrillation therapyECG monitoringRR intervalsHolter dataBaseline statePatientsArrhythmias
2006
Electrophysiologic characteristics of anger-triggered arrhythmias
Stopper M, Joska T, Burg MM, Batsford WP, McPherson CA, Jain D, Lampert R. Electrophysiologic characteristics of anger-triggered arrhythmias. Heart Rhythm 2006, 4: 268-273. PMID: 17341385, DOI: 10.1016/j.hrthm.2006.11.003.Peer-Reviewed Original ResearchConceptsVentricular arrhythmiasElectrophysiologic characteristicsPolymorphic ventricular tachycardiaMood statesDisorganized rhythmInitial therapyAppropriate shocksVentricular tachycardiaArrhythmogenic substrateSudden deathArrhythmiasPatientsIntracardiac electrogramsElectrogramsPossible mechanismTime of shockInitiation patternsTachycardiaTherapyInitiationICD
2005
Depression as a predictor for appropriate shocks among patients with implantable cardioverter-defibrillators Results from the Triggers of Ventricular Arrhythmias (TOVA) study
Whang W, Albert CM, Sears SF, Lampert R, Conti JB, Wang PJ, Singh JP, Ruskin JN, Muller JE, Mittleman MA, Investigators T. Depression as a predictor for appropriate shocks among patients with implantable cardioverter-defibrillators Results from the Triggers of Ventricular Arrhythmias (TOVA) study. Journal Of The American College Of Cardiology 2005, 45: 1090-1095. PMID: 15808769, DOI: 10.1016/j.jacc.2004.12.053.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseVT/VFSymptoms of depressionVentricular arrhythmiasSevere depressionAnderson-Gill proportional hazards modelsArrhythmia studiesImplantable cardioverter defibrillator patientsEpidemiologic Studies Depression ScaleCardioverter-defibrillator patientsFatal ventricular arrhythmiasProportional hazards modelRisk of shockCAD patientsFirst shockAppropriate shocksArtery diseaseICD dischargesICD patientsRecurrent episodesMultiple confoundersElevated riskSevere symptomsDepression severityHazards model