2019
Increased Diet Quality is Associated with Long‐Term Reduction of Abdominal and Pericardial Fat
Hennein R, Liu C, McKeown NM, Hoffmann U, Long MT, Levy D, Ma J. Increased Diet Quality is Associated with Long‐Term Reduction of Abdominal and Pericardial Fat. Obesity 2019, 27: 670-677. PMID: 30825267, PMCID: PMC6430652, DOI: 10.1002/oby.22427.Peer-Reviewed Original ResearchConceptsMediterranean-style diet scoreLess fat accumulationGenetic risk scoreFat accumulationDiet qualityAdipose tissueAbdominal subcutaneous adipose tissueEctopic fat depotsEctopic fat accumulationGenetic riskFramingham Heart Study participantsVisceral adipose tissuePericardial adipose tissueSubcutaneous adipose tissueDiet scorePericardial fatLong-term reductionRisk scoreFat depotsAdiposity profilesStudy participantsSD improvementFavorable changesLongitudinal associationsLongitudinal improvementA Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease
Ma J, Nano J, Ding J, Zheng Y, Hennein R, Liu C, Speliotes EK, Huan T, Song C, Mendelson MM, Joehanes R, Long MT, Liang L, Smith JA, Reynolds LM, Ghanbari M, Muka T, van Meurs JBJ, Alferink LJM, Franco OH, Dehghan A, Ratliff S, Zhao W, Bielak L, Kardia SLR, Peyser PA, Ning H, VanWagner LB, Lloyd-Jones DM, Carr JJ, Greenland P, Lichtenstein AH, Hu FB, Liu Y, Hou L, Murad S, Levy D. A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease. Diabetes 2019, 68: 1073-1083. PMID: 30936141, PMCID: PMC6477898, DOI: 10.2337/db18-1193.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseHepatic fatDNA methylation signaturesLiver diseasePopulation-based cohort studyMethylation signaturesNew-onset T2DType 2 diabetesHepatic fat accumulationMendelian randomization analysisCohort studyPotential causal pathwaysRisk factorsFat accumulationAfrican ancestry participantsEuropean ancestry participantsAttractive biomarkerCytosine-guanine dinucleotidesAssociation of hypomethylationWhole bloodHispanic ancestryRandomization analysisSame CpGsCausal pathways
2018
Barriers to medication adherence and links to cardiovascular disease risk factor control: the Framingham Heart Study
Hennein R, Hwang S, Au R, Levy D, Muntner P, Fox CS, Ma J. Barriers to medication adherence and links to cardiovascular disease risk factor control: the Framingham Heart Study. Internal Medicine Journal 2018, 48: 414-421. PMID: 29193523, PMCID: PMC5889324, DOI: 10.1111/imj.13687.Peer-Reviewed Original ResearchConceptsCVD risk factorsMini-Mental State ExaminationMedication adherenceLow adherenceRisk factorsFramingham Heart StudyCardiovascular diseaseDepressive symptomsHeart StudyCardiovascular disease risk factor controlHigher mean diastolic blood pressureMean low-density lipoprotein cholesterolFour-item Morisky Medication Adherence ScaleMean diastolic blood pressureMedian age 70 yearsLow-density lipoprotein cholesterolMorisky Medication Adherence ScaleFive-unit increaseRisk factor controlLipid-lowering medicationsDiastolic blood pressureMedication Adherence ScaleAge 70 yearsLow medication adherenceCES-D scores