2023
Pre- and peri-traumatic event stressors drive gender differences in chronic stress-related psychological sequelae: A prospective cohort study of COVID-19 frontline healthcare providers
Hennein R, Lowe S, Feingold J, Feder A, Peccoralo L, Ripp J, Mazure C, Pietrzak R. Pre- and peri-traumatic event stressors drive gender differences in chronic stress-related psychological sequelae: A prospective cohort study of COVID-19 frontline healthcare providers. Journal Of Psychiatric Research 2023, 162: 88-94. PMID: 37105023, DOI: 10.1016/j.jpsychires.2023.04.009.Peer-Reviewed Original ResearchConceptsMajor depressive disorderPosttraumatic stress disorderProspective cohort studyHealthcare providersCohort studyLarge tertiary care hospitalPsychological sequelaeSymptoms of MDDMental health risk factorsTertiary care hospitalProbable major depressive disorderWomen's healthcare providersHealth risk factorsFrontline healthcare providersCare hospitalRisk factorsDepressive disorderGender differencesStress disorderAnxiety disordersWomenSequelaeCOVID-19DisordersCOVID-19 pandemic
2021
Racial and Gender Discrimination Predict Mental Health Outcomes among Healthcare Workers Beyond Pandemic-Related Stressors: Findings from a Cross-Sectional Survey
Hennein R, Bonumwezi J, Nguemeni Tiako MJ, Tineo P, Lowe SR. Racial and Gender Discrimination Predict Mental Health Outcomes among Healthcare Workers Beyond Pandemic-Related Stressors: Findings from a Cross-Sectional Survey. International Journal Of Environmental Research And Public Health 2021, 18: 9235. PMID: 34501818, PMCID: PMC8431593, DOI: 10.3390/ijerph18179235.Peer-Reviewed Original ResearchConceptsMental health outcomesSymptoms of depressionHealth outcomesPosttraumatic stressAdverse mental health effectsMultivariable linear regression modelsAdverse mental health outcomesPandemic-related stressorsCross-sectional surveyInadequate social supportMental health effectsRisk factorsHealthcare workersMultivariable modelGeneral populationMental healthHealth effectsCOVID-19 pandemicLinear regression modelsOutcomesSymptomsSocial supportRegression modelsDepressionSubstantial stressor
2019
A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease
Ma J, Nano J, Ding J, Zheng Y, Hennein R, Liu C, Speliotes EK, Huan T, Song C, Mendelson MM, Joehanes R, Long MT, Liang L, Smith JA, Reynolds LM, Ghanbari M, Muka T, van Meurs JBJ, Alferink LJM, Franco OH, Dehghan A, Ratliff S, Zhao W, Bielak L, Kardia SLR, Peyser PA, Ning H, VanWagner LB, Lloyd-Jones DM, Carr JJ, Greenland P, Lichtenstein AH, Hu FB, Liu Y, Hou L, Murad S, Levy D. A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease. Diabetes 2019, 68: 1073-1083. PMID: 30936141, PMCID: PMC6477898, DOI: 10.2337/db18-1193.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseHepatic fatDNA methylation signaturesLiver diseasePopulation-based cohort studyMethylation signaturesNew-onset T2DType 2 diabetesHepatic fat accumulationMendelian randomization analysisCohort studyPotential causal pathwaysRisk factorsFat accumulationAfrican ancestry participantsEuropean ancestry participantsAttractive biomarkerCytosine-guanine dinucleotidesAssociation of hypomethylationWhole bloodHispanic ancestryRandomization analysisSame CpGsCausal pathways
2018
Barriers to medication adherence and links to cardiovascular disease risk factor control: the Framingham Heart Study
Hennein R, Hwang S, Au R, Levy D, Muntner P, Fox CS, Ma J. Barriers to medication adherence and links to cardiovascular disease risk factor control: the Framingham Heart Study. Internal Medicine Journal 2018, 48: 414-421. PMID: 29193523, PMCID: PMC5889324, DOI: 10.1111/imj.13687.Peer-Reviewed Original ResearchConceptsCVD risk factorsMini-Mental State ExaminationMedication adherenceLow adherenceRisk factorsFramingham Heart StudyCardiovascular diseaseDepressive symptomsHeart StudyCardiovascular disease risk factor controlHigher mean diastolic blood pressureMean low-density lipoprotein cholesterolFour-item Morisky Medication Adherence ScaleMean diastolic blood pressureMedian age 70 yearsLow-density lipoprotein cholesterolMorisky Medication Adherence ScaleFive-unit increaseRisk factor controlLipid-lowering medicationsDiastolic blood pressureMedication Adherence ScaleAge 70 yearsLow medication adherenceCES-D scores