2023
Pre- and peri-traumatic event stressors drive gender differences in chronic stress-related psychological sequelae: A prospective cohort study of COVID-19 frontline healthcare providers
Hennein R, Lowe S, Feingold J, Feder A, Peccoralo L, Ripp J, Mazure C, Pietrzak R. Pre- and peri-traumatic event stressors drive gender differences in chronic stress-related psychological sequelae: A prospective cohort study of COVID-19 frontline healthcare providers. Journal Of Psychiatric Research 2023, 162: 88-94. PMID: 37105023, DOI: 10.1016/j.jpsychires.2023.04.009.Peer-Reviewed Original ResearchConceptsMajor depressive disorderPosttraumatic stress disorderProspective cohort studyHealthcare providersCohort studyLarge tertiary care hospitalPsychological sequelaeSymptoms of MDDMental health risk factorsTertiary care hospitalProbable major depressive disorderWomen's healthcare providersHealth risk factorsFrontline healthcare providersCare hospitalRisk factorsDepressive disorderGender differencesStress disorderAnxiety disordersWomenSequelaeCOVID-19DisordersCOVID-19 pandemic
2019
A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease
Ma J, Nano J, Ding J, Zheng Y, Hennein R, Liu C, Speliotes EK, Huan T, Song C, Mendelson MM, Joehanes R, Long MT, Liang L, Smith JA, Reynolds LM, Ghanbari M, Muka T, van Meurs JBJ, Alferink LJM, Franco OH, Dehghan A, Ratliff S, Zhao W, Bielak L, Kardia SLR, Peyser PA, Ning H, VanWagner LB, Lloyd-Jones DM, Carr JJ, Greenland P, Lichtenstein AH, Hu FB, Liu Y, Hou L, Murad S, Levy D. A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease. Diabetes 2019, 68: 1073-1083. PMID: 30936141, PMCID: PMC6477898, DOI: 10.2337/db18-1193.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseHepatic fatDNA methylation signaturesLiver diseasePopulation-based cohort studyMethylation signaturesNew-onset T2DType 2 diabetesHepatic fat accumulationMendelian randomization analysisCohort studyPotential causal pathwaysRisk factorsFat accumulationAfrican ancestry participantsEuropean ancestry participantsAttractive biomarkerCytosine-guanine dinucleotidesAssociation of hypomethylationWhole bloodHispanic ancestryRandomization analysisSame CpGsCausal pathways