2023
Development and validation of a novel score to predict brain death after out-of-hospital cardiac arrest
Kitlen E, Kim N, Rubenstein A, Keenan C, Garcia G, Khosla A, Johnson J, Miller P, Wira C, Greer D, Gilmore E, Beekman R. Development and validation of a novel score to predict brain death after out-of-hospital cardiac arrest. Resuscitation 2023, 192: 109955. PMID: 37661012, DOI: 10.1016/j.resuscitation.2023.109955.Peer-Reviewed Original ResearchMeSH KeywordsBrain DeathCardiopulmonary ResuscitationHumansMiddle AgedOut-of-Hospital Cardiac ArrestRetrospective StudiesRisk FactorsConceptsHospital cardiac arrestBrain deathCardiac arrestOptimal cutEtiology of arrestDeath risk scoreNon-shockable rhythmOperator characteristic curveHours of arrestCenter cohortIndependent predictorsSulcal effacementUnResponsiveness (FOUR) scoreValidation cohortDevelopment cohortMAIN OUTCOMEHigh riskRisk scoreAcademic centersNovel scoreOHCACohortInternal validationRadiology reportsCharacteristic curveValidation of the rCAST score and comparison to the PCAC and FOUR scores for prognostication after out-of-hospital cardiac arrest
Kim N, Kitlen E, Garcia G, Khosla A, Miller P, Johnson J, Wira C, Greer D, Gilmore E, Beekman R. Validation of the rCAST score and comparison to the PCAC and FOUR scores for prognostication after out-of-hospital cardiac arrest. Resuscitation 2023, 188: 109832. PMID: 37178901, DOI: 10.1016/j.resuscitation.2023.109832.Peer-Reviewed Original ResearchMeSH KeywordsCardiopulmonary ResuscitationHumansHypothermia, InducedOut-of-Hospital Cardiac ArrestPrognosisRetrospective StudiesConceptsPoor neurologic outcomeUnited States cohortHospital cardiac arrestOHCA patientsNeurologic outcomeCardiac arrestPost-cardiac arrest syndromePoor neurological outcomeScore predictive abilityHospital mortalityNeurological outcomeUnResponsiveness (FOUR) scorePoor outcomeRetrospective studyAccurate outcome predictionPrognostic performanceFull OutlineDeLong testOutcome predictionPatientsMortalityOutcomesScoresCohortPredictive abilityBrain imaging after cardiac arrest
Beekman R, Hirsch K. Brain imaging after cardiac arrest. Current Opinion In Critical Care 2023, 29: 192-198. PMID: 37078612, DOI: 10.1097/mcc.0000000000001032.Peer-Reviewed Original ResearchMeSH KeywordsBrainHeart ArrestHumansNeuroimagingPrognosisReproducibility of ResultsRetrospective StudiesConceptsCardiac arrestComputed tomographyLong-term neurological outcomeQuantitative analysis of CTPrediction of long-term neurologic outcomeInterpretation of CTAnalysis of CTInterpreting CTBrain imagingNovel imaging techniquesNeurological outcomePoor outcomeDisorders of consciousnessNeurological injuryLack of specificityMRIInter-rater reliabilityQuantitative image analysisArrestOutcomesImaging techniquesBrainMultimodal assessmentMethodological limitationsPatientsEmergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchMeSH KeywordsAdultCerebral HemorrhageDrainageFactor XaFactor Xa InhibitorsFibrinolytic AgentsHumansProspective StudiesRecombinant ProteinsRetrospective StudiesThrombosisConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patients
2022
Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest
Beekman R, Crawford A, Mazurek MH, Prabhat AM, Chavva IR, Parasuram N, Kim N, Kim JA, Petersen N, de Havenon A, Khosla A, Honiden S, Miller PE, Wira C, Daley J, Payabvash S, Greer DM, Gilmore EJ, Kimberly W, Sheth KN. Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest. Resuscitation 2022, 176: 150-158. PMID: 35562094, PMCID: PMC9746653, DOI: 10.1016/j.resuscitation.2022.05.002.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain InjuriesCritical IllnessFemaleHeart ArrestHumansHypoxia-Ischemia, BrainMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesConceptsCardiac arrestBrain injuryHypoxic-ischemic brain injuryAdverse neurological outcomesIschemic brain injurySingle-center studyBrain magnetic resonanceBrain injury severityBoard-certified neuroradiologistsLow-field MRIFLAIR signal intensityNeurological outcomeCA patientsIll patientsMRI findingsCA survivorsCenter studyMRI examinationsClinical careHigh riskInjury severityPatientsSignal intensityBedside monitoringMR imaging
2021
Early head CT in post-cardiac arrest patients: A helpful tool or contributor to self-fulfilling prophecy?
Beekman R, Maciel CB, Ormseth CH, Zhou SE, Galluzzo D, Miyares LC, Torres-Lopez VM, Payabvash S, Mak A, Greer DM, Gilmore EJ. Early head CT in post-cardiac arrest patients: A helpful tool or contributor to self-fulfilling prophecy? Resuscitation 2021, 165: 68-76. PMID: 34147572, DOI: 10.1016/j.resuscitation.2021.06.004.Peer-Reviewed Original ResearchMeSH KeywordsGray MatterHeart ArrestHumansPrognosisReproducibility of ResultsRetrospective StudiesTomography, X-Ray ComputedConceptsGray-white matter ratioHCT findingsArrest patientsInter-rater reliabilityPost-cardiac arrest patientsTertiary care academic medical centerEarly head CTPost-CA carePost-CA patientsCardiac arrest patientsHalf of casesAcademic medical centerElectronic medical recordsWithdrawal of lifeNeurophysiologic testingSpontaneous circulationInjury burdenMedical recordsHead CTTherapeutic decisionsMedical CenterPatientsNeurointensivistsHctTemperature management
2019
Differential outcomes following successful resuscitation in cardiac arrest due to drug overdose
Ormseth CH, Maciel CB, Zhou SE, Barden MM, Miyares LC, Beekman RB, Gilmore EJ, Greer DM. Differential outcomes following successful resuscitation in cardiac arrest due to drug overdose. Resuscitation 2019, 139: 9-16. PMID: 30965094, DOI: 10.1016/j.resuscitation.2019.04.004.Peer-Reviewed Original ResearchConceptsCardiac arrestNeurological recoveryClinical characteristicsDrug overdoseBrain deathCerebral Performance Category scoreCA casesFavorable neurological recoverySimilar neurological recoveryLarge prospective studiesPositive toxicology screenRankin Scale scorePotential treatment optionSingle academic institutionBystander cardiopulmonary resuscitationHospital dischargeInpatient mortalitySuccessful resuscitationToxicology screenProspective studyTreatment optionsMedical recordsMedication administrationCardiopulmonary resuscitationRetrospective analysisDistinct predictive values of current neuroprognostic guidelines in post-cardiac arrest patients
Zhou SE, Maciel CB, Ormseth CH, Beekman R, Gilmore EJ, Greer DM. Distinct predictive values of current neuroprognostic guidelines in post-cardiac arrest patients. Resuscitation 2019, 139: 343-350. PMID: 30951843, PMCID: PMC6589093, DOI: 10.1016/j.resuscitation.2019.03.035.Peer-Reviewed Original ResearchConceptsPost-cardiac arrest patientsAmerican Heart AssociationArrest patientsPredictive valueDiffuse hypoxic-ischemic injurySingle tertiary care centerDistinct predictive valuesHypoxic-ischemic injuryOutcomes of patientsTertiary care centerLife-sustaining therapyIntensive care medicineFalse positive rateAAN guidelinesAHA guidelinesHospital recordsCardiac arrestHeart AssociationCare centerCurrent guidelinesCare medicineBetter outcomesBiochemical findingsPatientsAmerican Academy