2024
Can Clinical Scores Predict the Presence of Hypoxic Ischemic Brain Injury on Early Head Computed Tomography After Cardiac Arrest? (P6-2.001)
Nguyen C, Molligoda B, Kim N, Kitlen E, Wira C, Perman S, Khosla A, Miller P, Greer D, Gilmore E, Beekman R. Can Clinical Scores Predict the Presence of Hypoxic Ischemic Brain Injury on Early Head Computed Tomography After Cardiac Arrest? (P6-2.001). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206255.Peer-Reviewed Original Research
2023
Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study
Prasad A, Gilmore E, Kim J, Begunova L, Olexa M, Beekman R, Falcone G, Matouk C, Ortega-Gutierrez S, Temkin N, Barber J, Diaz-Arrastia R, de Havenon A, Petersen N. Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study. Neurocritical Care 2023, 41: 91-99. PMID: 38158481, PMCID: PMC11285118, DOI: 10.1007/s12028-023-01896-x.Peer-Reviewed Original ResearchCerebral perfusion pressureBrain tissue hypoxiaSevere traumatic brain injuryTissue hypoxiaTraumatic brain injuryBlood pressureCerebral hypoperfusionBrain injuryAutoregulatory functionMean cerebral perfusion pressureSecondary analysisOptimal cerebral perfusion pressurePercent timeCerebral autoregulatory functionLimits of autoregulationPhase II trialArterial blood pressureBrain tissue oxygenIntracranial pressure monitoringCPP augmentationHemodynamic augmentationAutoregulatory indexII trialBP managementPerfusion pressureTemperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions
Beekman R, Khosla A, Buckley R, Honiden S, Gilmore E. Temperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions. Journal Of Intensive Care Medicine 2023, 39: 611-622. PMID: 37787185, DOI: 10.1177/08850666231203596.Peer-Reviewed Original ResearchHypoxic-ischemic brain injuryCardiac arrestPopulation-based thresholdsDuration of therapyCardiac arrest survivorsCause of deathRobust preclinical evidencePatient-centered careCritical future stepNeurologic outcomeNeuroprotective therapiesPreclinical evidenceArrest survivorsClinical equipoiseBrain injuryCurrent guidelinesFever preventionIndividualized targetOnly interventionTherapeutic windowInsufficient evidenceResearch prioritiesPersonalized approachMetabolic demandsCore temperatureExpanding beyond ischemic stroke: A qualitative MRI score that facilitates outcome prediction in patients with hypoxic ischemic brain injury
Beekman R, Hirsch K. Expanding beyond ischemic stroke: A qualitative MRI score that facilitates outcome prediction in patients with hypoxic ischemic brain injury. Resuscitation 2023, 187: 109800. PMID: 37080336, DOI: 10.1016/j.resuscitation.2023.109800.Peer-Reviewed Original Research
2022
Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest
Beekman R, Crawford A, Mazurek MH, Prabhat AM, Chavva IR, Parasuram N, Kim N, Kim JA, Petersen N, de Havenon A, Khosla A, Honiden S, Miller PE, Wira C, Daley J, Payabvash S, Greer DM, Gilmore EJ, Kimberly W, Sheth KN. Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest. Resuscitation 2022, 176: 150-158. PMID: 35562094, PMCID: PMC9746653, DOI: 10.1016/j.resuscitation.2022.05.002.Peer-Reviewed Original ResearchConceptsCardiac arrestBrain injuryHypoxic-ischemic brain injuryAdverse neurological outcomesIschemic brain injurySingle-center studyBrain magnetic resonanceBrain injury severityBoard-certified neuroradiologistsLow-field MRIFLAIR signal intensityNeurological outcomeCA patientsIll patientsMRI findingsCA survivorsCenter studyMRI examinationsClinical careHigh riskInjury severityPatientsSignal intensityBedside monitoringMR imaging
2021
Neuromonitoring After Cardiac Arrest Can Twenty-First Century Medicine Personalize Post Cardiac Arrest Care?
Beekman R, Maciel CB, Balu R, Greer DM, Gilmore EJ. Neuromonitoring After Cardiac Arrest Can Twenty-First Century Medicine Personalize Post Cardiac Arrest Care? Neurologic Clinics 2021, 39: 273-292. PMID: 33896519, DOI: 10.1016/j.ncl.2021.01.002.Peer-Reviewed Original ResearchConceptsSecondary brain injuryCardiac arrest careBrain injuryArrest carePost-cardiac arrest syndromeHypoxic-ischemic brain injuryPost-cardiac arrest careEtiology of arrestSecondary neurologic injuryCardiac arrest survivorsNeurologic comorbiditiesNeuromonitoring toolsNeurologic injuryArrest survivorsCardiac arrestNeuromonitoring techniquesCerebral physiologyPhysiologic variablesIndividualized approachRisk profileInjuryHeterogeneous populationCareArrestComorbidities