Activation of cortical 5-HT3 receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions
Perrenoud Q, Rossier J, Férézou I, Geoffroy H, Gallopin T, Vitalis T, Rancillac A. Activation of cortical 5-HT3 receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions. Frontiers In Neural Circuits 2012, 6: 50. PMID: 22907992, PMCID: PMC3415676, DOI: 10.3389/fncir.2012.00050.Peer-Reviewed Original ResearchCerebral blood flowNeuronal nitric oxide synthase inhibitorNitric oxide synthase inhibitorNPY receptor antagonistsOxide synthase inhibitorVasoactive intestinal peptideMouse neocortical slicesBlood-vessel diameter changesVessel diameter changesNPY releaseL-NNANeurogliaform cellsRich innervationVascular toneIntestinal peptideNeuropeptide YAscending pathwaysGABAergic interneuronsReceptor antagonistSupragranular layersSerotoninergic inputSomatosensory cortexBath applicationNeocortical slicesVasoactive molecules