Quentin Perrenoud, PhD
Associate Research Scientist in NeuroscienceCards
About
Research
Publications
2023
Beyond rhythm – a framework for understanding the frequency spectrum of neural activity
Perrenoud Q, Cardin J. Beyond rhythm – a framework for understanding the frequency spectrum of neural activity. Frontiers In Systems Neuroscience 2023, 17: 1217170. PMID: 37719024, PMCID: PMC10500127, DOI: 10.3389/fnsys.2023.1217170.Peer-Reviewed Original ResearchPutting the brakes on synchrony: VIP interneurons tune visually evoked rhythmic activity
Perrenoud Q, Cardin J. Putting the brakes on synchrony: VIP interneurons tune visually evoked rhythmic activity. Neuron 2023, 111: 297-299. PMID: 36731427, DOI: 10.1016/j.neuron.2023.01.004.Peer-Reviewed Original Research
2014
Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin
Rossier J, Bernard A, Cabungcal J, Perrenoud Q, Savoye A, Gallopin T, Hawrylycz M, Cuénod M, Do K, Urban A, Lein E. Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin. Molecular Psychiatry 2014, 20: 154-161. PMID: 25510509, PMCID: PMC4356748, DOI: 10.1038/mp.2014.162.Peer-Reviewed Original ResearchConceptsPerineuronal netsSomatosensory cerebral cortexWisteria floribunda agglutininCerebral cortexParvalbumin interneuronsCortical interneuronsInterneuron markersAmyloid β-peptidePatch clampAllen Mouse Brain AtlasInterneuronsPattern of expressionSpecific markersMouse Brain AtlasPvalbAllen AtlasADAMTS15NeprilysinBrain atlasMultiplex PCRΒ-peptideMarkers
2012
Diversity of GABAergic Interneurons in Layer VIa and VIb of Mouse Barrel Cortex
Perrenoud Q, Rossier J, Geoffroy H, Vitalis T, Gallopin T. Diversity of GABAergic Interneurons in Layer VIa and VIb of Mouse Barrel Cortex. Cerebral Cortex 2012, 23: 423-441. PMID: 22357664, DOI: 10.1093/cercor/bhs032.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideNeuropeptide YGABAergic interneuronsLayer VIBarrel cortexWhole-cell current-clamp recordingsMouse somatosensory barrel cortexSingle-cell reverse transcription-polymerase chain reactionAminobutyric acidergic interneuronsNeocortical layer VIMouse barrel cortexSomatosensory barrel cortexCurrent-clamp recordingsReverse transcription-polymerase chain reactionTypes of interneuronsTranscription-polymerase chain reactionGABAergic cellsIntestinal peptideAcute slicesBiocytin labelingTransgenic miceInterneuronsThalamocortical transferSomatostatinParvalbuminCharacterization of Type I and Type II nNOS-Expressing Interneurons in the Barrel Cortex of Mouse
Perrenoud Q, Geoffroy H, Gauthier B, Rancillac A, Alfonsi F, Kessaris N, Rossier J, Vitalis T, Gallopin T. Characterization of Type I and Type II nNOS-Expressing Interneurons in the Barrel Cortex of Mouse. Frontiers In Neural Circuits 2012, 6: 36. PMID: 22754499, PMCID: PMC3386492, DOI: 10.3389/fncir.2012.00036.Peer-Reviewed Original ResearchType II neuronsVasoactive intestinal peptideType I neuronsMedial ganglionic eminenceNeuronal nitric oxide synthaseDeep layer neuronsI neuronsCaudal ganglionic eminenceBarrel cortexGanglionic eminenceLayers II/IIIExpression of parvalbuminNitric oxide synthaseWhole-cell recordingsType IType II cellsNNOS immunohistochemistryDorsal preoptic areaGABAergic neuronsIntestinal peptideOxide synthasePreoptic areaBiocytin labelingSomatostatinEx vivoActivation of cortical 5-HT3 receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions
Perrenoud Q, Rossier J, Férézou I, Geoffroy H, Gallopin T, Vitalis T, Rancillac A. Activation of cortical 5-HT3 receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions. Frontiers In Neural Circuits 2012, 6: 50. PMID: 22907992, PMCID: PMC3415676, DOI: 10.3389/fncir.2012.00050.Peer-Reviewed Original ResearchCerebral blood flowNeuronal nitric oxide synthase inhibitorNitric oxide synthase inhibitorNPY receptor antagonistsOxide synthase inhibitorVasoactive intestinal peptideMouse neocortical slicesBlood-vessel diameter changesVessel diameter changesNPY releaseL-NNANeurogliaform cellsRich innervationVascular toneIntestinal peptideNeuropeptide YAscending pathwaysGABAergic interneuronsReceptor antagonistSupragranular layersSerotoninergic inputSomatosensory cortexBath applicationNeocortical slicesVasoactive molecules
2009
Degenerative abnormalities in transgenic neocortical neuropeptide Y interneurons expressing tau‐green fluorescent protein
Rancillac A, Lainé J, Perrenoud Q, Geoffroy H, Ferezou I, Vitalis T, Rossier J. Degenerative abnormalities in transgenic neocortical neuropeptide Y interneurons expressing tau‐green fluorescent protein. Journal Of Neuroscience Research 2009, 88: 487-499. PMID: 19830842, DOI: 10.1002/jnr.22234.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsDendritesFluorescent Antibody TechniqueIn Vitro TechniquesInterneuronsLuminescent ProteinsLysineMaleMiceMice, Inbred C57BLMice, TransgenicMicroscopy, ImmunoelectronNeurodegenerative DiseasesNeuropeptide YPatch-Clamp TechniquesReverse Transcriptase Polymerase Chain ReactionSomatosensory CortexTau ProteinsConceptsLysosomal-associated membrane protein 1Bacterial artificial chromosomeGreen fluorescent proteinFluorescent proteinGene of interestElectrophysiological intrinsic propertiesTranscriptional controlTau-green fluorescent proteinArtificial chromosomesGenomic sequencesMembrane protein 1BAC transgenic miceReporter geneReporter constructsMorphological defectsLysosomal vacuolesCell typesProtein tauProtein 1Electrophysiological defectsRestricted spatial distributionElectron microscopic analysisGenesProteinTransgenic mice