2017
Cryo-EM structure of human ATR-ATRIP complex
Rao Q, Liu M, Tian Y, Wu Z, Hao Y, Song L, Qin Z, Ding C, Wang H, Wang J, Xu Y. Cryo-EM structure of human ATR-ATRIP complex. Cell Research 2017, 28: 143-156. PMID: 29271416, PMCID: PMC5799817, DOI: 10.1038/cr.2017.158.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAtaxia Telangiectasia Mutated ProteinsCarrier ProteinsChromatography, AffinityChromatography, GelCryoelectron MicroscopyDNA DamageDNA-Binding ProteinsHumansIsoxazolesMutationNuclear ProteinsPhosphorylationProtein BindingProtein Conformation, alpha-HelicalProtein FoldingProtein KinasesProtein MultimerizationPyrazinesSignal TransductionTOR Serine-Threonine KinasesConceptsATR-ATRIP complexCryo-electron microscopy structureATR protein kinasesTerminal catalytic coreCryo-EM structureDNA repair pathwaysMicroscopy structureReplication stressFunctional diversityProtein kinaseCatalytic coreRepair pathwaysStructural basisN-terminusATRIPCatalytic pocketEM mapsDistinct conformationsDNA damageConformational flexibilityInhibitory elementsATRComplex formationCritical roleComplexes
2015
Structural insight into substrate preference for TET-mediated oxidation
Hu L, Lu J, Cheng J, Rao Q, Li Z, Hou H, Lou Z, Zhang L, Li W, Gong W, Liu M, Sun C, Yin X, Li J, Tan X, Wang P, Wang Y, Fang D, Cui Q, Yang P, He C, Jiang H, Luo C, Xu Y. Structural insight into substrate preference for TET-mediated oxidation. Nature 2015, 527: 118-122. PMID: 26524525, DOI: 10.1038/nature15713.Peer-Reviewed Original Research
2013
Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation
Hu L, Li Z, Cheng J, Rao Q, Gong W, Liu M, Shi Y, Zhu J, Wang P, Xu Y. Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation. Cell 2013, 155: 1545-1555. PMID: 24315485, DOI: 10.1016/j.cell.2013.11.020.Peer-Reviewed Original ResearchConceptsCatalytic cavityCys-rich domainMutations of TET2CpG contextTET proteinsHuman TET2Zinc fingerCatalytic domainSubstrate preferenceÅ resolutionStructural basisCpG dinucleotideBiological processesMyeloid malignancesHuman cancersDNATET2MutationsCrystal structureMethyl groupTetImportant roleDomainProteinResidues