2017
Cryo-EM structure of human ATR-ATRIP complex
Rao Q, Liu M, Tian Y, Wu Z, Hao Y, Song L, Qin Z, Ding C, Wang H, Wang J, Xu Y. Cryo-EM structure of human ATR-ATRIP complex. Cell Research 2017, 28: 143-156. PMID: 29271416, PMCID: PMC5799817, DOI: 10.1038/cr.2017.158.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAtaxia Telangiectasia Mutated ProteinsCarrier ProteinsChromatography, AffinityChromatography, GelCryoelectron MicroscopyDNA DamageDNA-Binding ProteinsHumansIsoxazolesMutationNuclear ProteinsPhosphorylationProtein BindingProtein Conformation, alpha-HelicalProtein FoldingProtein KinasesProtein MultimerizationPyrazinesSignal TransductionTOR Serine-Threonine KinasesConceptsATR-ATRIP complexCryo-electron microscopy structureATR protein kinasesTerminal catalytic coreCryo-EM structureDNA repair pathwaysMicroscopy structureReplication stressFunctional diversityProtein kinaseCatalytic coreRepair pathwaysStructural basisN-terminusATRIPCatalytic pocketEM mapsDistinct conformationsDNA damageConformational flexibilityInhibitory elementsATRComplex formationCritical roleComplexes
2013
Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation
Hu L, Li Z, Cheng J, Rao Q, Gong W, Liu M, Shi Y, Zhu J, Wang P, Xu Y. Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation. Cell 2013, 155: 1545-1555. PMID: 24315485, DOI: 10.1016/j.cell.2013.11.020.Peer-Reviewed Original ResearchConceptsCatalytic cavityCys-rich domainMutations of TET2CpG contextTET proteinsHuman TET2Zinc fingerCatalytic domainSubstrate preferenceÅ resolutionStructural basisCpG dinucleotideBiological processesMyeloid malignancesHuman cancersDNATET2MutationsCrystal structureMethyl groupTetImportant roleDomainProteinResidues