2022
Cryo-EM structure of an active central apparatus
Han L, Rao Q, Yang R, Wang Y, Chai P, Xiong Y, Zhang K. Cryo-EM structure of an active central apparatus. Nature Structural & Molecular Biology 2022, 29: 472-482. PMID: 35578022, PMCID: PMC9113940, DOI: 10.1038/s41594-022-00769-9.Peer-Reviewed Original ResearchConceptsCentral apparatusDiverse cellular activitiesKinesin-like proteinCryo-EM structureArmadillo repeat proteinsCryo-electron microscopyHigh-resolution structuresEukaryotic speciesProtein subunitsMotile ciliaBridge proteinsPair of microtubulesRegulatory roleCellular activitiesProteinDynamic conformational behaviorCiliary motilityCiliaCiliary beatingStructural frameworkConformational behaviorSubunitsMicrotubulesRegulatorSpecies
2015
Structural insight into substrate preference for TET-mediated oxidation
Hu L, Lu J, Cheng J, Rao Q, Li Z, Hou H, Lou Z, Zhang L, Li W, Gong W, Liu M, Sun C, Yin X, Li J, Tan X, Wang P, Wang Y, Fang D, Cui Q, Yang P, He C, Jiang H, Luo C, Xu Y. Structural insight into substrate preference for TET-mediated oxidation. Nature 2015, 527: 118-122. PMID: 26524525, DOI: 10.1038/nature15713.Peer-Reviewed Original Research
2013
Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation
Hu L, Li Z, Cheng J, Rao Q, Gong W, Liu M, Shi Y, Zhu J, Wang P, Xu Y. Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation. Cell 2013, 155: 1545-1555. PMID: 24315485, DOI: 10.1016/j.cell.2013.11.020.Peer-Reviewed Original ResearchConceptsCatalytic cavityCys-rich domainMutations of TET2CpG contextTET proteinsHuman TET2Zinc fingerCatalytic domainSubstrate preferenceÅ resolutionStructural basisCpG dinucleotideBiological processesMyeloid malignancesHuman cancersDNATET2MutationsCrystal structureMethyl groupTetImportant roleDomainProteinResidues