Effect of Endoscopic Sphincterotomy for Suspected Sphincter of Oddi Dysfunction on Pain-Related Disability Following Cholecystectomy: The EPISOD Randomized Clinical Trial
Cotton PB, Durkalski V, Romagnuolo J, Pauls Q, Fogel E, Tarnasky P, Aliperti G, Freeman M, Kozarek R, Jamidar P, Wilcox M, Serrano J, Brawman-Mintzer O, Elta G, Mauldin P, Thornhill A, Hawes R, Wood-Williams A, Orrell K, Drossman D, Robuck P. Effect of Endoscopic Sphincterotomy for Suspected Sphincter of Oddi Dysfunction on Pain-Related Disability Following Cholecystectomy: The EPISOD Randomized Clinical Trial. JAMA 2014, 311: 2101-2109. PMID: 24867013, PMCID: PMC4428324, DOI: 10.1001/jama.2014.5220.Peer-Reviewed Original ResearchConceptsEndoscopic retrograde cholangiopancreatographySuccessful treatmentDual sphincterotomyAbdominal painOddi dysfunctionEndoscopic sphincterotomyBiliary sphincterotomyObservational study groupPancreatic sphincter hypertensionPancreatic sphincter pressuresReferral medical centerDays of disabilitySuccess of treatmentERCP interventionPancreatic sphincterotomyFinal followPain reliefManometry findingsSphincter pressureSphincterotomy groupManometry resultsNarcotic useRetrograde cholangiopancreatographySham groupClinical trials