2015
Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection
Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, Shultz LD, Mempel TR, Bjorkman PJ, Kumar P, Mothes W. Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection. Science 2015, 350: 563-567. PMID: 26429886, PMCID: PMC4651917, DOI: 10.1126/science.aab2749.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusLymph nodesMurine leukemia virusCD169/SiglecSecondary lymphoid tissuesPermissive lymphocytesDendritic cellsImmunodeficiency virusSynaptic contactsLymphoid tissueRobust infectionVirological synapsesI-type lectinsRetroviral spreadViral spreadUninfected cellsInfectionLeukemia virusVirusMacrophagesCellsRetrovirusesCell-cell contactCD169Lymphocytes
2007
Transvascular delivery of small interfering RNA to the central nervous system
Kumar P, Wu H, McBride JL, Jung KE, Hee Kim M, Davidson BL, Kyung Lee S, Shankar P, Manjunath N. Transvascular delivery of small interfering RNA to the central nervous system. Nature 2007, 448: 39-43. PMID: 17572664, DOI: 10.1038/nature05901.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBlood-Brain BarrierBrainCell LineDrug Delivery SystemsEncephalitis Virus, JapaneseEncephalitis, JapaneseGene SilencingGenetic VectorsGlycoproteinsGreen Fluorescent ProteinsHeLa CellsHumansLentivirusLiposomesMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred NODMice, SCIDMolecular Sequence DataNeuronsOligopeptidesRabies virusReceptors, NicotinicRecombinant ProteinsRNA, Small InterferingSuperoxide DismutaseSuperoxide Dismutase-1Viral ProteinsConceptsRVG-9RBlood-brain barrierRabies virus glycoproteinNeuronal cellsTransvascular deliveryFatal viral encephalitisCentral nervous systemTherapeutic moleculesIntravenous treatmentViral encephalitisInflammatory cytokinesAntiviral siRNAIntravenous injectionNervous systemAcetylcholine receptorsNeurological diseasesAnti-peptide antibodiesChimaeric peptidesNoninvasive approachDelivery of siRNABrainSiRNAMiceVirus glycoproteinRobust protection