2024
A Divergent Synthesis of Numerous Pyrroloiminoquinone Alkaloids Identifies Promising Antiprotozoal Agents
Barnes G, Magann N, Perrotta D, Hörmann F, Fernandez S, Vydyam P, Choi J, Prudhomme J, Neal A, Le Roch K, Mamoun C, Vanderwal C. A Divergent Synthesis of Numerous Pyrroloiminoquinone Alkaloids Identifies Promising Antiprotozoal Agents. Journal Of The American Chemical Society 2024, 146: 29883-29894. PMID: 39412402, PMCID: PMC11528414, DOI: 10.1021/jacs.4c11897.Peer-Reviewed Original ResearchNatural productsLarock indole synthesisAlkaloid natural productsAmine nucleophilesDivergent synthesisIndole synthesisPyrrolic nitrogenMethoxy groupLead compoundsDrug discoveryCompoundsStructural analogsPlasmodium falciparum</i>SynthesisPyrroloiminoquinoneHuman cytotoxicityMalaria parasitesNucleophilesPyrroleAntiprotozoal agentsAminesMammalian cellsIntermediate
2019
Benzimidazolinone-Free Peptide o‑Aminoanilides for Chemical Protein Synthesis
Mannuthodikayil J, Singh S, Biswas A, Kar A, Tabassum W, Vydyam P, Bhattacharyya M, Mandal K. Benzimidazolinone-Free Peptide o‑Aminoanilides for Chemical Protein Synthesis. Organic Letters 2019, 21: 9040-9044. PMID: 31663760, DOI: 10.1021/acs.orglett.9b03440.Peer-Reviewed Original ResearchConceptsPeptide synthesisSolid-phase peptide synthesisChemical protein synthesisPhase peptide synthesisTotal chemical synthesisSerious side reactionsPeptide thioestersChemical synthesisEfficient synthesisSide reactionsDiaminobenzoic acidO-aminoanilidesSynthesisThioestersAminesBocFormationCarbamateHereinReactionOptional attachmentSolubility tagAcidPeptidesC-terminus