Plasma chitotriosidase activity versus CCL18 level for assessing type I Gaucher disease severity: protocol for a systematic review with meta-analysis of individual participant data
Raskovalova T, Deegan PB, Yang R, Pavlova E, Stirnemann J, Labarère J, Zimran A, Mistry PK, Berger M. Plasma chitotriosidase activity versus CCL18 level for assessing type I Gaucher disease severity: protocol for a systematic review with meta-analysis of individual participant data. Systematic Reviews 2017, 6: 87. PMID: 28427477, PMCID: PMC5397740, DOI: 10.1186/s13643-017-0483-x.Peer-Reviewed Original ResearchConceptsPlasma chitotriosidase activityIndividual participant dataChitotriosidase activitySystematic reviewCCL18 levelsPlatelet countSpleen volumeHemoglobin concentrationDisease severityCC chemokine ligand 18Participant dataCochrane Central RegisterDiagnostic Accuracy Studies-2 toolChemokine ligand 18Collaborative systematic reviewWide clinical spectrumConfidence intervalsUnpredictable natural courseGD activityEffect size estimatesAutosomal recessive lysosomal storage disorderRecessive lysosomal storage disorderLarge-scale headCentral RegisterLysosomal storage disorder