The golden age for patients in their golden years: The progressive upheaval of age and the treatment of newly-diagnosed acute myeloid leukemia
Shallis RM, Boddu PC, Bewersdorf JP, Zeidan AM. The golden age for patients in their golden years: The progressive upheaval of age and the treatment of newly-diagnosed acute myeloid leukemia. Blood Reviews 2019, 40: 100639. PMID: 31761380, DOI: 10.1016/j.blre.2019.100639.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInduction therapyAcute myeloid leukemia patientsMost acute myeloid leukemia (AML) patientsAML patients ageIntensive induction therapyLeukemic stem cell persistenceOptimal treatment modalityMyeloid leukemia patientsPatient-specific factorsAcute myeloid leukemiaAvailability of therapiesMedical comorbiditiesOlder patientsPatient ageIntensive therapyOrgan reserveTreatment algorithmEarly mortalityLongstanding recommendationsTreatment modalitiesSuch therapyLeukemia patientsMyeloid leukemiaPatientsTherapyGut Microbiome Signatures Are Predictive of Infectious Risk Following Induction Therapy for Acute Myeloid Leukemia
Galloway-Peña JR, Shi Y, Peterson CB, Sahasrabhojane P, Gopalakrishnan V, Brumlow CE, Daver NG, Alfayez M, Boddu PC, Khan A, Wargo JA, Do KA, Jenq RR, Kontoyiannis DP, Shelburne SA. Gut Microbiome Signatures Are Predictive of Infectious Risk Following Induction Therapy for Acute Myeloid Leukemia. Clinical Infectious Diseases 2019, 71: 63-71. PMID: 31436833, PMCID: PMC7312220, DOI: 10.1093/cid/ciz777.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaInduction chemotherapyNeutrophil recoveryInfectious complicationsAML patientsMyeloid leukemiaAcute myeloid leukemia induction chemotherapyGut microbiome signaturesInfectious risk stratificationHematologic malignancy patientsExtended spectrum βSubsequent infectious complicationsStrong independent predictorHigher baseline levelsInduction therapyInfectious outcomesMalignancy patientsCarbapenem useIndependent predictorsTransplant settingAntibiotic administrationClinical outcomesRisk stratificationStool samplesMicrobiome signatures