CAR‐T Therapy in Clinical Practice: Technical Advances and Current Challenges
Ren P, Zhang C, Li W, Wang X, Liang A, Yang G, Xu H, Ma P. CAR‐T Therapy in Clinical Practice: Technical Advances and Current Challenges. Advanced Biology 2022, 6: e2101262. PMID: 35652169, DOI: 10.1002/adbi.202101262.Peer-Reviewed Original ResearchMeSH KeywordsHumansImmunotherapy, AdoptivePrecursor Cell Lymphoblastic Leukemia-LymphomaReceptors, Antigen, T-CellReceptors, Chimeric AntigenT-LymphocytesConceptsChimeric antigen receptorCAR T cellsCAR-T therapyClinical trialsCAR T-cell therapyAcute lymphoblastic leukemiaSuccessful clinical outcomeB-cell lymphomaT cell engineeringStandard tumor therapiesAntigen recognition domainComplete responseClinical outcomesTumor toxicityLymphoblastic leukemiaT cellsCell lymphomaClinical experiencePoor efficacyClinical practiceSolid tumorsTumor resistanceTherapyAntitumor efficacyCell therapy