Alcohol Regulates Gene Expression in Neurons via Activation of Heat Shock Factor 1
Pignataro L, Miller AN, Ma L, Midha S, Protiva P, Herrera DG, Harrison NL. Alcohol Regulates Gene Expression in Neurons via Activation of Heat Shock Factor 1. Journal Of Neuroscience 2007, 27: 12957-12966. PMID: 18032669, PMCID: PMC6673276, DOI: 10.1523/jneurosci.4142-07.2007.Peer-Reviewed Original ResearchConceptsHeat shock factor 1Alcohol-responsive genesShock factor 1Gene expressionHeat shockHSF1-dependent genesDownstream DNA sequenceHeat shock pathwayNeuron-specific genesARE-like sequencesFactor 1Long-term physiological changesDNA sequencesAlters transcriptionSequence elementsMicroarray analysisHSF1 levelsResponse elementMouse cortical neuronsGenesMouse cerebral cortexShock pathwayGABRA4Cultured neuronsHSP70