2008
Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response
Protiva P, Hopkins ME, Baggett S, Yang H, Lipkin M, Holt PR, Kennelly EJ, Bernard WI. Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response. International Journal Of Cancer 2008, 123: 687-694. PMID: 18470880, DOI: 10.1002/ijc.23515.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 4ApoptosisBenzophenonesCaspasesCell CycleCell Line, TumorCell SurvivalColonic NeoplasmsDNA-Binding ProteinsEndoplasmic ReticulumGarciniaGene Expression Regulation, NeoplasticHCT116 CellsHT29 CellsHumansInhibitory Concentration 50Linear ModelsMitochondrial MembranesNuclear ProteinsPrenylationProtein KinasesReactive Oxygen SpeciesRegulatory Factor X Transcription FactorsSignal TransductionTOR Serine-Threonine KinasesTranscription Factor CHOPTranscription FactorsUp-RegulationX-Box Binding Protein 1ConceptsEndoplasmic reticulum stress responseMitochondrial membrane potentialColon cancer cellsReticulum stress responseCaspase activationGene expressionStress responseSurvival pathwaysDDIT3/CHOPGuttiferone EEndoplasmic reticulum responseHuman colon cancer cellsParallel molecular pathwaysCell survival pathwaysCancer cellsCell linesMembrane potentialColon cancer cell linesHuman colon cancer cell linesREDD1 geneGene arrayMTOR survival pathwayCell cycleMolecular pathwaysCancer cell lines
2003
Cox-2 is needed but not sufficient for apoptosis induced by Cox-2 selective inhibitors in colon cancer cells
Agarwal B, Swaroop P, Protiva P, Raj S, Shirin H, Holt P. Cox-2 is needed but not sufficient for apoptosis induced by Cox-2 selective inhibitors in colon cancer cells. Apoptosis 2003, 8: 649-654. PMID: 14739610, DOI: 10.1023/a:1026199929747.Peer-Reviewed Original ResearchConceptsHCT116 cellsHT29 cellsProtein expressionColon cancer cellsColon cancer cell linesCell numberCOX-2 protein expressionCancer cell linesApoptosisProtein levelsCancer cellsCell linesExpressionSelective inhibitorHT29CellsFlow cytometryCOX-2 protein levelsInhibitorsCOX-2COX-2 expressionHCT116High levelsRoleΜMPhenylacetate induces G1/S arrest and apoptosis in colon cancer cells but antagonizes S-phase specific chemotherapy
Protiva P, Agarwal B, Shimizu M, Weinstein I, Holt P. Phenylacetate induces G1/S arrest and apoptosis in colon cancer cells but antagonizes S-phase specific chemotherapy. Gastroenterology 2003, 124: a463. DOI: 10.1016/s0016-5085(03)82342-9.Peer-Reviewed Original Research