2020
P.499 Ketamine's influence on global resting-state functional connectivity and individual variation in neuro-behavioural relationships
Moujaes F, Preller K, Vollenweider F, Schleifer C, Adkinson B, Kolobaric A, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, D. M, Anticevic A. P.499 Ketamine's influence on global resting-state functional connectivity and individual variation in neuro-behavioural relationships. European Neuropsychopharmacology 2020, 40: s278-s279. DOI: 10.1016/j.euroneuro.2020.09.363.Peer-Reviewed Original Research
2019
S159. NMDA Receptor Antagonism Effects on Delayed Spatial Working Memory and Distraction in Comparison With Schizophrenia
Moujaes F, Preller K, Vollenweider F, Schleifer C, Ji J, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, Murray J, Anticevic A. S159. NMDA Receptor Antagonism Effects on Delayed Spatial Working Memory and Distraction in Comparison With Schizophrenia. Biological Psychiatry 2019, 85: s358. DOI: 10.1016/j.biopsych.2019.03.910.Peer-Reviewed Original ResearchF195. NMDAR Antagonism via Ketamine Differentially Modulates Thalamic Versus Hippocampal Brain-Wide Functional Connectivity
Moujaes F, Schleifer C, Ji L, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Cho Y, Santamauro N, Morgan P, Savic A, Murray J, Anticevic A. F195. NMDAR Antagonism via Ketamine Differentially Modulates Thalamic Versus Hippocampal Brain-Wide Functional Connectivity. Biological Psychiatry 2019, 85: s289. DOI: 10.1016/j.biopsych.2019.03.732.Peer-Reviewed Original Research
2018
Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial
D'Souza DC, Cortes-Briones J, Creatura G, Bluez G, Thurnauer H, Deaso E, Bielen K, Surti T, Radhakrishnan R, Gupta A, Gupta S, Cahill J, Sherif MA, Makriyannis A, Morgan PT, Ranganathan M, Skosnik PD. Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial. The Lancet Psychiatry 2018, 6: 35-45. PMID: 30528676, DOI: 10.1016/s2215-0366(18)30427-9.Peer-Reviewed Original ResearchConceptsPF-04457845Cannabis withdrawal symptomsFatty acid amide hydrolaseCannabis withdrawalPlacebo groupAdverse eventsCannabis useWithdrawal symptomsFatty acid amide hydrolase inhibitorSerious adverse eventsPhase 2a trialWeeks of treatmentTreatment of cannabisCannabis use disorderSelf-reported cannabis useDSM-IV criteriaTreatment-related differencesTHC-COOH concentrationsAnandamide concentrationsTreat populationPrimary endpointPill countHospital admissionNovel FAAH inhibitorsSelf-reported cannabisThe Barriers and Benefits to Developing Forensic Rotations for Psychiatry Residents.
Michaelsen KC, Lewis AS, Morgan PT, McKee SA, Wasser TD. The Barriers and Benefits to Developing Forensic Rotations for Psychiatry Residents. The Journal Of The American Academy Of Psychiatry And The Law 2018, 46: 322-328. PMID: 30368464, DOI: 10.29158/jaapl.003766-18.Peer-Reviewed Original ResearchConceptsForensic experienceForensic psychiatryJustice-involved patientsPsychiatry residents’ experiencesCurrent regulatory frameworkRegulatory frameworkForensic trainingResident experienceFuture fellowsForensic practiceClassroom-based activitiesInstitutionsEducation requirementsExperiencePracticeChallengesCouncilCountriesProgramAuthorsResidentsArticleEducatorsTraining programMedical Education requirements165. Modulation of Sleep and Circadian Rhythm in the Treatment of Cocaine Use Disorder
Morgan P. 165. Modulation of Sleep and Circadian Rhythm in the Treatment of Cocaine Use Disorder. Biological Psychiatry 2018, 83: s67. DOI: 10.1016/j.biopsych.2018.02.183.Peer-Reviewed Original Research92. Using Pharmacological Neuroimaging to Understand Microcircuit E/I Imbalance in Humans
Anticevic A, Schleifer C, Adkinson B, Cho Y, Morgan P, Savic A, Demirtas M, Ji J, Murray J. 92. Using Pharmacological Neuroimaging to Understand Microcircuit E/I Imbalance in Humans. Biological Psychiatry 2018, 83: s38. DOI: 10.1016/j.biopsych.2018.02.109.Peer-Reviewed Original Research168. The Effect of Fatty Acid Amide Hydrolase Inhibition on Sleep Architecture in Cannabis Withdrawal
Skosnik P, Cortes-Briones J, Creatura G, Morgan P, Ranganathan M, Deaso E, Surti T, D'Souza D. 168. The Effect of Fatty Acid Amide Hydrolase Inhibition on Sleep Architecture in Cannabis Withdrawal. Biological Psychiatry 2018, 83: s68. DOI: 10.1016/j.biopsych.2018.02.186.Peer-Reviewed Original Research
2017
Ketamine and Sleep: Bridging the Gap in the Treatment of Depressive Illness
Morgan PT. Ketamine and Sleep: Bridging the Gap in the Treatment of Depressive Illness. Biological Psychiatry 2017, 82: 309-311. PMID: 28781004, DOI: 10.1016/j.biopsych.2017.07.005.Peer-Reviewed Original Research423 NMDAR Antagonism via Ketamine Differentially Modulates Thalamic versus Hippocampal Functional Connectivity
Anticevic A, Schleifer C, Srihari V, Krystal J, Murray J, Repovs G, Xu G, Ji L, Cho Y, Santamauro N, Foss-Feig J, Yang G, Morgan P, Savic A. 423 NMDAR Antagonism via Ketamine Differentially Modulates Thalamic versus Hippocampal Functional Connectivity. Biological Psychiatry 2017, 81: s172-s173. DOI: 10.1016/j.biopsych.2017.02.907.Peer-Reviewed Original ResearchComputerized Cognitive Behavioral Therapy for Insomnia in a Community Health Setting.
Feuerstein S, Hodges SE, Keenaghan B, Bessette A, Forselius E, Morgan PT. Computerized Cognitive Behavioral Therapy for Insomnia in a Community Health Setting. Journal Of Clinical Sleep Medicine 2017, 13: 267-274. PMID: 27784409, PMCID: PMC5263082, DOI: 10.5664/jcsm.6460.Peer-Reviewed Original ResearchConceptsPittsburgh Sleep Quality IndexCo-occurring mental illnessCognitive behavioral therapyMental illnessBehavioral therapyI groupCommunity mental health centerCommunity health settingsMore psychotropic medicationsSleep Quality IndexComputerized cognitive behavioral therapyMental health care treatmentMental health centersWeekly outpatient sessionsLow socioeconomic statusHealth care treatmentPSQI scoresPsychotropic medicationsCare treatmentActive control groupHealth centersInsomnia treatmentOutpatient sessionsRisk demographicsWeek 6
2016
Sleep Perception and Misperception in Chronic Cocaine Users During Abstinence
Hodges SE, Pittman B, Morgan PT. Sleep Perception and Misperception in Chronic Cocaine Users During Abstinence. Sleep 2016, 40: zsw069. PMID: 28364419, PMCID: PMC5806585, DOI: 10.1093/sleep/zsw069.Peer-Reviewed Original ResearchConceptsChronic cocaine usersSleep state misperceptionWeeks of abstinenceTotal sleep timeOccult insomniaCocaine usersState misperceptionSleep onsetSleep timeCocaine-dependent personsInpatient research facilitySleep latencyDiary questionnairesSleep perceptionPolysomnographic sleep recordingsDiary measurementsAbstinenceTreatment studiesFinal awakeningMisperceptionsNight 3Objective worseningParticipantsInsomniaSleep recordingsSchizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition
Starc M, Murray JD, Santamauro N, Savic A, Diehl C, Cho YT, Srihari V, Morgan PT, Krystal JH, Wang XJ, Repovs G, Anticevic A. Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition. Schizophrenia Research 2016, 181: 107-116. PMID: 27745755, PMCID: PMC5901719, DOI: 10.1016/j.schres.2016.10.011.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsSpatial WM taskSchizophrenia patientsSevere cognitive deficitsSpecific spatial locationsComputational modelContinuous response measuresWM precisionWM representationsSpatial WMWM taskDistractor distanceWM impairmentWM tracesNeural mechanismsCognitive deficitsMemory deficitsBehavioral consequencesDelay periodDelay durationCortical disinhibitionSpatial locationComparison subjectsMicrocircuit modelDistractibilitySleep abnormalities associated with alcohol, cannabis, cocaine, and opiate use: a comprehensive review
Angarita GA, Emadi N, Hodges S, Morgan PT. Sleep abnormalities associated with alcohol, cannabis, cocaine, and opiate use: a comprehensive review. Addiction Science & Clinical Practice 2016, 11: 9. PMID: 27117064, PMCID: PMC4845302, DOI: 10.1186/s13722-016-0056-7.Peer-Reviewed Original ResearchModafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence
Morgan PT, Angarita GA, Canavan S, Pittman B, Oberleitner L, Malison RT, Mohsenin V, Hodges S, Easton C, McKee S, Bessette A, Forselius E. Modafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence. Drug And Alcohol Dependence 2016, 160: 49-56. PMID: 26777774, PMCID: PMC4767553, DOI: 10.1016/j.drugalcdep.2015.12.004.Peer-Reviewed Original ResearchConceptsUrine toxicology screenModafinil treatmentSlow-wave sleepClinical outcomesOutpatient treatmentToxicology screenUrine screensInpatient settingInpatient treatmentSleep timeCocaine dependencePrimary clinical outcomeWeekly cognitive behavioral therapyCocaine usersImproved clinical outcomesPolysomnographic sleep recordingsChronic cocaine useChronic cocaine usersHigh rateCognitive behavioral therapyCocaine-dependent participantsSleep architectureOutpatient phaseEffective treatmentDays abstinentChapter 21 Sleep and Cocaine
Angarita G, Canavan S, Hodges S, Morgan P. Chapter 21 Sleep and Cocaine. 2016, 220-228. DOI: 10.1016/b978-0-12-800212-4.00021-2.Peer-Reviewed Original ResearchPoor cognitive performanceChronic cocaine usersChapter 21 SleepObjective sleep abnormalitiesCocaine use disorderOccult insomniaCognitive performanceSleep architectureMood dysregulationSleep experiencesCocaine usersAbstinenceSleepSleep abnormalitiesInsomniaCocaineDisordersOutcomesExperienceDysregulationBetter outcomesProfound abnormalities
2015
Association of Cigarette Smoking With Interpersonal and Self-Directed Violence in a Large Community-Based Sample
Lewis AS, Oberleitner LM, Morgan PT, Picciotto MR, McKee SA. Association of Cigarette Smoking With Interpersonal and Self-Directed Violence in a Large Community-Based Sample. Nicotine & Tobacco Research 2015, 18: 1456-1462. PMID: 26718905, PMCID: PMC5942535, DOI: 10.1093/ntr/ntv287.Peer-Reviewed Original ResearchConceptsCigarette smoking statusSmoking statusCigarette smokingSelf-directed violenceRisk factorsDaily smokersViolence risk assessmentWave 1Substance useFormer cigarette smokersFormer daily smokersDaily cigarette smokingMajor risk factorNational Epidemiological SurveyCommunity-based sampleLogistic regression modelsRelevant demographic covariatesViolence risk factorsCessation strategiesCigarette smokersPsychiatric diagnosisEpidemiological surveySmokersSmokingAdult subjectsPsychosocial and metabolic function by smoking status in individuals with binge eating disorder and obesity
Udo T, White MA, Barnes RD, Ivezaj V, Morgan P, Masheb RM, Grilo CM. Psychosocial and metabolic function by smoking status in individuals with binge eating disorder and obesity. Addictive Behaviors 2015, 53: 46-52. PMID: 26451703, PMCID: PMC4679522, DOI: 10.1016/j.addbeh.2015.09.018.Peer-Reviewed Original ResearchConceptsTreatment-seeking adultsTreatment-seeking patientsSubstance use disordersDisorder psychopathologyCurrent smokersFormer smokersPsychosocial functioningComorbid psychiatric disordersSmoking statusLifetime psychiatric comorbidityUse disordersLifetime diagnostic criteriaPotential long-term implicationsFunctioningBingePsychiatric comorbidityMeeting criteriaPsychiatric disordersMetabolic functionsMetabolic functioningMetabolic riskMetabolic syndromeMetabolic abnormalitiesSmoking cessationSmokersKetamine-Induced Hallucinations
Powers A, Gancsos MG, Finn ES, Morgan PT, Corlett PR. Ketamine-Induced Hallucinations. Psychopathology 2015, 48: 376-385. PMID: 26361209, PMCID: PMC4684980, DOI: 10.1159/000438675.Peer-Reviewed Original ResearchConceptsAuditory verbal hallucinationsPerceptual inputVerbal hallucinationsPredictive coding modelDelusion-like ideasPerceptual disruptionsPerceptual expectationsPerceptual environmentCoding modelPhenomenological experienceSensory stimuliStimulation environmentAuditory hallucinationsHealthy participantsHallmark symptomFirst-episode psychosisMusical hallucinationsMRI scannerHallucinationsParticipantsMagnetic resonance imaging (MRI) scannerPsychosisAmotivationPerceptVivid hallucinations
2014
Effects of endogenous and exogenous progesterone on emotional intelligence in cocaine‐dependent men and women who also abuse alcohol
Milivojevic V, Sinha R, Morgan PT, Sofuoglu M, Fox HC. Effects of endogenous and exogenous progesterone on emotional intelligence in cocaine‐dependent men and women who also abuse alcohol. Human Psychopharmacology Clinical And Experimental 2014, 29: 589-598. PMID: 25363303, PMCID: PMC4498951, DOI: 10.1002/hup.2446.Peer-Reviewed Original ResearchConceptsEmotional intelligenceStudy 1Caruso Emotional Intelligence TestAbstinent cocaine-dependent individualsEmotional Intelligence TestRegulation of emotionCocaine-dependent individualsCocaine-dependent menFunction of genderManaging emotionsIntelligence testsEmotionsSelective aspectsSubstance dependenceGender effectsSex differencesMenstrual cycle phaseIntelligenceGender discrepancyMSCEITSaloveyImproved abilityIndividualsGonadal hormonesHealthy individuals