2014
Dreams, reality and memory: confabulations in lucid dreamers implicate reality-monitoring dysfunction in dream consciousness
Corlett PR, Canavan SV, Nahum L, Appah F, Morgan PT. Dreams, reality and memory: confabulations in lucid dreamers implicate reality-monitoring dysfunction in dream consciousness. Cognitive Neuropsychiatry 2014, 19: 540-553. PMID: 25028078, PMCID: PMC4160044, DOI: 10.1080/13546805.2014.932685.Peer-Reviewed Original ResearchConceptsReality monitoringDream awarenessDefault-mode brain functionSignal detection theory analysisLiberal acceptance biasVentromedial prefrontal cortexDetection theory analysisModel-based reinforcement learningNon-psychotic individualsNotion of overlapCognitive tasksTask runsMemory errorsPrefrontal cortexDream consciousnessPsychotic experiencesBrain functionAltered statesReinforcement learningPerceptionCurrent perceptionsTaskResearch settingsLucid dreamersConsciousness
2012
NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBrainCognitionDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleHumansInfusions, IntravenousKetamineMagnetic Resonance ImagingMaleMemoryModels, NeurologicalPattern Recognition, VisualPsychomotor PerformanceReceptors, N-Methyl-D-AspartateSchizophreniaSynaptic TransmissionYoung AdultConceptsNeural systemsLarge-scale brain systemsTask-dependent activationN-methyl-D-aspartate receptorsRealistic computational modelingSevere neuropsychiatric illnessNMDA glutamate receptor antagonistGlutamate receptor antagonistsBrain systemsNMDA receptor functionTask performanceMultiple interacting regionsCognitionCortical disinhibitionGlutamatergic neurotransmissionReceptor antagonistCortical computationGlutamate's roleReciprocal relationshipNeuropsychiatric illnessLocal circuitsReceptor functionSchizophreniaPresent findingsComputational modeling
2009
Retrograde effects of triazolam and zolpidem on sleep‐dependent motor learning in humans
MORGAN PT, KEHNE JH, SPRENGER KJ, MALISON RT. Retrograde effects of triazolam and zolpidem on sleep‐dependent motor learning in humans. Journal Of Sleep Research 2009, 19: 157-164. PMID: 19682231, DOI: 10.1111/j.1365-2869.2009.00757.x.Peer-Reviewed Original ResearchConceptsTotal sleep timeSleep timeMotor learningSleep-dependent motor learningRapid eye movement (REM) sleepLonger total sleep timeGamma-aminobutyric acid receptor complexEye movement sleepREM onset latencyHealthy male subjectsStage 2 sleepMemory consolidationRetrograde effectsTriazolam conditionZolpidem conditionSkill memory consolidationMovement sleepSleep-dependent memory consolidationSufficient dosesHealthy peopleSleep laboratoryPlacebo conditionBenzodiazepine siteOnset latencyMale subjects