2016
Modafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence
Morgan PT, Angarita GA, Canavan S, Pittman B, Oberleitner L, Malison RT, Mohsenin V, Hodges S, Easton C, McKee S, Bessette A, Forselius E. Modafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence. Drug And Alcohol Dependence 2016, 160: 49-56. PMID: 26777774, PMCID: PMC4767553, DOI: 10.1016/j.drugalcdep.2015.12.004.Peer-Reviewed Original ResearchConceptsUrine toxicology screenModafinil treatmentSlow-wave sleepClinical outcomesOutpatient treatmentToxicology screenUrine screensInpatient settingInpatient treatmentSleep timeCocaine dependencePrimary clinical outcomeWeekly cognitive behavioral therapyCocaine usersImproved clinical outcomesPolysomnographic sleep recordingsChronic cocaine useChronic cocaine usersHigh rateCognitive behavioral therapyCocaine-dependent participantsSleep architectureOutpatient phaseEffective treatmentDays abstinent
2013
Abstinence-related changes in sleep during treatment for cocaine dependence
Angarita GA, Canavan SV, Forselius E, Bessette A, Pittman B, Morgan PT. Abstinence-related changes in sleep during treatment for cocaine dependence. Drug And Alcohol Dependence 2013, 134: 343-347. PMID: 24315572, PMCID: PMC4396819, DOI: 10.1016/j.drugalcdep.2013.11.007.Peer-Reviewed Original ResearchConceptsTotal sleep timeExtended abstinenceOutpatient cognitive behavioral therapyAbstinence-related changesDecreased slow wave sleepInpatient substance abuse treatmentCognitive behavioral therapySleep timeCocaine usersPolysomnographic sleepChronic cocaine usersCocaine-dependent participantsSubstance abuse treatmentThrice weekly urine toxicologyBehavioral therapyWeeks of abstinenceOverall sleep qualityAbuse treatmentDays abstinentDependent participantsREM sleep latencySleep qualityCocaine dependenceSlow-wave sleepAbstinence
2010
Normalizing Effects of Modafinil on Sleep in Chronic Cocaine Users
Morgan PT, Pace-Schott E, Pittman B, Stickgold R, Malison RT. Normalizing Effects of Modafinil on Sleep in Chronic Cocaine Users. American Journal Of Psychiatry 2010, 167: 331-340. PMID: 20080983, PMCID: PMC5857958, DOI: 10.1176/appi.ajp.2009.09050613.Peer-Reviewed Original ResearchMeSH KeywordsAdultBenzhydryl CompoundsCentral Nervous System StimulantsCocaineCocaine-Related DisordersDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleHumansMaleMiddle AgedModafinilPolysomnographySleep Wake DisordersSubstance Abuse Treatment CentersSubstance Withdrawal SyndromeWakefulnessConceptsMultiple sleep latency testSlow-wave sleep timeSleep latency testEffects of modafinilTotal sleep timeSleep latencyCocaine-dependent participantsSleep timeChronic cocaine usersDaytime sleepinessLatency testCocaine usersShorter REM sleep latencyDaytime sleep latencyLonger total sleep timeREM sleep latencySubjective daytime sleepinessSleep architecture variablesPolysomnographic sleep recordingsSleep architectureNocturnal sleepHealthy comparison participantsAbstinent cocaine usersDay 1Day 2