2018
Genomic Heterogeneity and the Small Renal Mass
Ueno D, Xie Z, Boeke M, Syed J, Nguyen KA, McGillivray P, Adeniran A, Humphrey P, Dancik GM, Kluger Y, Liu Z, Kluger H, Shuch B. Genomic Heterogeneity and the Small Renal Mass. Clinical Cancer Research 2018, 24: 4137-4144. PMID: 29760223, PMCID: PMC6125159, DOI: 10.1158/1078-0432.ccr-18-0214.Peer-Reviewed Original Research
2006
Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger
Wild P, Giedl J, Stoehr R, Junker K, Boehm S, van Oers J, Zwarthoff E, Blaszyk H, Fine S, Humphrey P, Dehner L, Amin M, Epstein J, Hartmann A. Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger. The Journal Of Pathology 2006, 211: 18-25. PMID: 17072825, DOI: 10.1002/path.2075.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlphapapillomavirusChildChild, PreschoolChromosome AberrationsChromosomes, Human, Pair 9DNA Mismatch RepairDNA Mutational AnalysisDNA, ViralFemaleGene Expression ProfilingGenes, p53HumansImmunohistochemistryIn Situ Hybridization, FluorescenceLoss of HeterozygosityMaleMicrosatellite InstabilityOligonucleotide Array Sequence AnalysisPapillomaPolymerase Chain ReactionReceptor, Fibroblast Growth Factor, Type 3Urologic NeoplasmsUrotheliumConceptsPatients 19 yearsUrothelial neoplasmsUrothelial papillomaMicrosatellite instabilityClinical outcomesHuman papillomavirusTP53 mutationsHigh-grade papillary urothelial carcinomaNIH consensus panelEvidence of diseaseFavorable clinical outcomeLow malignant potentialChromosome arm 9pPapillary urothelial carcinomaComparative genomic hybridizationPapillary urothelial neoplasmHPV positivityYounger patientsMultifocal tumorsUrothelial carcinomaUrothelial tumorsMalignant potentialPolymerase chain reactionConsensus panelKi-67
2001
Chromosome 22q dosage in composite extrarenal rhabdoid tumors: Clonal evolution or a phenotypic mimic?
Fuller C, Pfeifer J, Humphrey P, Bruch L, Dehner L, Perry A. Chromosome 22q dosage in composite extrarenal rhabdoid tumors: Clonal evolution or a phenotypic mimic? Human Pathology 2001, 32: 1102-1108. PMID: 11679945, DOI: 10.1053/hupa.2001.28252.Peer-Reviewed Original ResearchVisceral primitive peripheral neuroectodermal tumors: A clinicopathologic and molecular study
O'Sullivan M, Perlman E, Furman J, Humphrey P, Dehner L, Pfeifer J. Visceral primitive peripheral neuroectodermal tumors: A clinicopathologic and molecular study. Human Pathology 2001, 32: 1109-1115. PMID: 11679946, DOI: 10.1053/hupa.2001.28247.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal NeoplasmsAdolescentAdultBiomarkers, TumorDNA PrimersDNA, NeoplasmFemaleHumansImmunoenzyme TechniquesMaleMiddle AgedNeoplasm ProteinsNeuroectodermal Tumors, Primitive, PeripheralOncogene Proteins, FusionProto-Oncogene Protein c-fli-1Reverse Transcriptase Polymerase Chain ReactionRNA, MessengerRNA, NeoplasmRNA-Binding Protein EWSSarcoma, EwingSoft Tissue NeoplasmsTomography, X-Ray ComputedTranscription FactorsVisceraConceptsEWS/PNETSoft tissuePediatric small round blue cell tumorsSarcoma-primitive neuroectodermal tumorPolymerase chain reaction-based testingFusion transcriptsSmall round blue cell tumorsRound blue cell tumorsBlue cell tumorsClinicopathologic spectrumVisceral sitesPrognostic significanceVisceral originVisceral tumorsCell tumorsNeuroectodermal tumorAdditional casesTumorsPNETYoung adultsGenetic alterationsEts transcription factor familyBoneChromosomal translocationsEWS-FLI1Primitive Neuroectodermal Tumors of the Biliary and Gastrointestinal Tracts: Clinicopathologic and Molecular Diagnostic Study of Two Cases
Sarangarajan R, Hill D, Humphrey P, Hitchcock M, Dehner L, Pfeifer J. Primitive Neuroectodermal Tumors of the Biliary and Gastrointestinal Tracts: Clinicopathologic and Molecular Diagnostic Study of Two Cases. Pediatric And Developmental Pathology 2001, 4: 185-191. PMID: 11178636, DOI: 10.1007/s100240010141.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBile Duct NeoplasmsBiomarkers, TumorDNA PrimersDNA, NeoplasmFemaleHepatic Duct, CommonHumansImmunoenzyme TechniquesJejunal NeoplasmsMaleNeoplasm ProteinsNeoplasms, Second PrimaryNeuroectodermal Tumors, Primitive, PeripheralReverse Transcriptase Polymerase Chain ReactionRNA, NeoplasmSequence Analysis, DNAWilms TumorConceptsPrimitive neuroectodermal tumorNeuroectodermal tumorMalignant small round cell tumorMalignant soft tissue tumorsSmall round cell tumorSoft tissue tumorsRound cell tumorNon-classical sitesMore conventional sitesEWS-FLI1 gene fusionMolecular diagnostic studiesTranscription-polymerase chain reaction analysisCharacteristic immunoreactivityHepatic ductCell tumorsClinicopathologic profileTissue tumorsGastrointestinal tractChain reaction analysisUnusual siteSmall intestineTumorsMolecular findingsTumor cellsDiagnostic studies
2000
Evaluation of a chronic indwelling prototype mesh ureteral stent in a porcine model
Olweny E, Portis A, Sundaram C, Afane J, Humphrey P, Ewers R, McDougall E, Clayman R. Evaluation of a chronic indwelling prototype mesh ureteral stent in a porcine model. Urology 2000, 56: 857-862. PMID: 11068323, DOI: 10.1016/s0090-4295(00)00734-2.Peer-Reviewed Original ResearchRenal Cell Carcinoma With Rhabdoid Features
Gökden N, Nappi O, Swanson P, Pfeifer J, Vollmer R, Wick M, Humphrey P. Renal Cell Carcinoma With Rhabdoid Features. The American Journal Of Surgical Pathology 2000, 24: 1329-1338. PMID: 11023094, DOI: 10.1097/00000478-200010000-00002.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaAdult renal cell carcinomaGlial fibrillary acidic proteinEpithelial membrane antigenNeuron-specific enolaseMuscle-specific actinSmooth muscle actinCases of RCCRhabdoid featuresCell carcinomaRhabdoid componentRhabdoid elementsRhabdoid tumorIncidence of RCCGrade 4 casesGrade 2 casesRadical nephrectomy specimensGrade I casesFibrillary acidic proteinGrade 3 casesPanel of antibodiesLarge epithelioid cellsIntracytoplasmic hyaline globulesHigh-stage carcinomasMajority of casesLAPAROSCOPIC AUGMENTATION CYSTOPLASTY WITH DIFFERENT BIODEGRADABLE GRAFTS IN AN ANIMAL MODEL
PORTIS A, ELBAHNASY A, SHALHAV A, BREWER A, HUMPHREY P, MCDOUGALL E, CLAYMAN R. LAPAROSCOPIC AUGMENTATION CYSTOPLASTY WITH DIFFERENT BIODEGRADABLE GRAFTS IN AN ANIMAL MODEL. Journal Of Urology 2000, 164: 1405-1411. PMID: 10992423, DOI: 10.1016/s0022-5347(05)67207-2.Peer-Reviewed Original ResearchConceptsSmall intestinal submucosaHuman placental membranesAcellular tissue matrixBladder capacityLaparoscopic techniqueSIS groupBladder wall replacementLaparoscopic partial cystectomyTransitional cell epitheliumBovine pericardiumIntracorporeal suturing techniquesEvidence of encrustationSignificant inflammatory responseLapra-Ty clipsHost bladderPartial cystectomyAugmentation cystoplastyBladder augmentationMucosal coverageUrethral catheterBPC groupFree graftEndostitch deviceInflammatory responseBladder wallWT1 Staining Reliably Differentiates Desmoplastic Small Round Cell Tumor From Ewing Sarcoma/Primitive Neuroectodermal Tumor
Hill D, Pfeifer J, Marley E, Dehner L, Humphrey P, Zhu X, Swanson P. WT1 Staining Reliably Differentiates Desmoplastic Small Round Cell Tumor From Ewing Sarcoma/Primitive Neuroectodermal Tumor. American Journal Of Clinical Pathology 2000, 114: 345-353. PMID: 10989634, DOI: 10.1093/ajcp/114.3.345.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal NeoplasmsAdolescentAdultBiomarkers, TumorBlotting, SouthernChildChild, PreschoolDiagnosis, DifferentialDNA PrimersDNA, NeoplasmDNA-Binding ProteinsFemaleFibromatosis, AggressiveHumansImmunoenzyme TechniquesMaleNeuroectodermal Tumors, PrimitiveOncogene Proteins, FusionParotid NeoplasmsReverse Transcriptase Polymerase Chain ReactionSarcoma, EwingSequence Analysis, DNATranscription FactorsWT1 ProteinsConceptsDesmoplastic small round cell tumorSmall round cell tumorRound cell tumorEWS/PNETSarcoma/primitive neuroectodermal tumorPrimitive neuroectodermal tumorCell tumorsWT1 antibodyImmunohistochemical featuresNeuroectodermal tumorDiagnosis of DSRCTMalignant small round cell tumorEwing sarcoma/primitive neuroectodermal tumorEWS/PNETsRT-PCRReverse transcriptase-polymerase chain reaction analysisTranscriptase-polymerase chain reaction analysisWT1 stainingEWS-WT1 fusionChain reaction analysisPredictive valueTumorsAvailable tissueConcurrent Ki-67 and p53 Immunolabeling in Cutaneous Melanocytic Neoplasms: An Adjunct for Recognition of the Vertical Growth Phase in Malignant Melanomas?
Kaleem Z, Lind A, Humphrey P, Sueper R, Swanson P, Ritter J, Wick M. Concurrent Ki-67 and p53 Immunolabeling in Cutaneous Melanocytic Neoplasms: An Adjunct for Recognition of the Vertical Growth Phase in Malignant Melanomas? Modern Pathology 2000, 13: 217-222. PMID: 10757331, DOI: 10.1038/modpathol.3880040.Peer-Reviewed Original Research
1997
CT of cystic renal masses: analysis of diagnostic performance and interobserver variation.
Siegel C, McFarland E, Brink J, Fisher A, Humphrey P, Heiken J. CT of cystic renal masses: analysis of diagnostic performance and interobserver variation. American Journal Of Roentgenology 1997, 169: 813-8. PMID: 9275902, DOI: 10.2214/ajr.169.3.9275902.Peer-Reviewed Original ResearchComparison of Fibrin Glue, Laser Weld, and Mechanical Suturing Device for the Laparoscopic Closure of Ureterotomy in a Porcine Model
Wolf S, Soble J, Nakada S, Rayala H, Humphrey P, Clayman R, Poppas D. Comparison of Fibrin Glue, Laser Weld, and Mechanical Suturing Device for the Laparoscopic Closure of Ureterotomy in a Porcine Model. Journal Of Urology 1997, 157: 1487-1492. PMID: 9120988, DOI: 10.1016/s0022-5347(01)65029-8.Peer-Reviewed Original ResearchPrimitive Neuroectodermal Tumor of the Kidney-Another Enigma: a Pathologic, Immunohistochemical, and Molecular Diagnostic Study
Marley E, Liapis H, Humphrey P, Nadler R, Siegel C, Zhu X, Brandt J, Dehner L. Primitive Neuroectodermal Tumor of the Kidney-Another Enigma: a Pathologic, Immunohistochemical, and Molecular Diagnostic Study. The American Journal Of Surgical Pathology 1997, 21: 354-359. PMID: 9060607, DOI: 10.1097/00000478-199703000-00013.Peer-Reviewed Original ResearchConceptsPrimitive neuroectodermal tumorPolymerase chain reactionNeuroectodermal tumorRenal primitive neuroectodermal tumorPrimary primitive neuroectodermal tumorComplete immunohistochemical evaluationNeuron-specific enolasePrimitive round cellsDecades of lifeSoft tissue neoplasmSites of predilectionMolecular diagnostic studiesFormation of rosettesAbdominal painAbdominal massImmunohistochemical evaluationParaspinal regionEwing's sarcomaChest wallRound cellsTumor cellsCharacteristic translocationDiagnostic studiesProgenitor cellsKidneyIn Vivo Comparison of Electrosurgical Vaporization Electrodes
Wolf J, Rayala H, Humphrey P, Clayman R. In Vivo Comparison of Electrosurgical Vaporization Electrodes. Journal Of Endourology 1997, 11: 83-87. PMID: 9048305, DOI: 10.1089/end.1997.11.83.Peer-Reviewed Original ResearchMetastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal Samples
Mallow D, Humphrey P, Soper J, Johnston W. Metastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal Samples. Acta Cytologica 1997, 41: 549-555. PMID: 9100797, DOI: 10.1159/000332555.Peer-Reviewed Original ResearchConceptsMetastatic lobular carcinomaLobular carcinomaCervicovaginal samplesCervicovaginal smearsHuman milk fat globule membraneEpithelial membrane antigenEpidermal growth factor receptorExtragenital originExtrauterine cancerGrowth factor receptorMalignant tumorsTherapeutic implicationsMembrane antigenCarcinoembryonic antigenHistologic correlationFactor receptorMarker studiesCarcinomaMilk fat globule membraneBreastAntigenSmearsFat globule membraneGlobule membraneTumorsLaparoscopic pyeloplasty in the animal model.
McDougall E, Elashry O, Clayman R, Humphrey P, Rayah H. Laparoscopic pyeloplasty in the animal model. JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 1997, 1: 113-8. PMID: 9876657, PMCID: PMC3021264.Peer-Reviewed Original ResearchConceptsLaparoscopic pyeloplastyIntracorporeal suturing techniquesOperative timeEndostitch deviceSecondary ureteropelvic junction obstructionSuturing techniqueDifferent laparoscopic techniquesUnilateral UPJ obstructionLonger operative timeUreteropelvic junction obstructionLapra-Ty clipsRenal functionRenal scanSerum creatinineRenal biopsyUrine cultureGeneral anesthesiaJunction obstructionRetrograde pyelographyUreteral catheterizationLaparoscopic techniqueUPJ obstruction
1996
The Unintubated Ureterotomy Endourologically Revisited
Gardner S, Wolf S, Nakada S, Moon Y, Figenshau R, Pearle M, Soble J, Humphrey P, Clayman R. The Unintubated Ureterotomy Endourologically Revisited. Journal Of Urology 1996, 156: 1160-1163. PMID: 8709338, DOI: 10.1016/s0022-5347(01)65742-2.Peer-Reviewed Original Research
1995
Laparoscopic Pneumodissection: A Unique Means of Tissue Dissection
Gardner S, Clayman R, McDougall E, Moon Y, Fadden P, Anderson K, Pearle M, Royal H, Humphrey P, Pingleton E, Roemer F. Laparoscopic Pneumodissection: A Unique Means of Tissue Dissection. Journal Of Urology 1995, 154: 591-594. PMID: 7609143, DOI: 10.1016/s0022-5347(01)67117-9.Peer-Reviewed Original ResearchConceptsRenal scanRenal hilumBlood gasesChronic tissue effectsRenal damageLaparoscopic proceduresClinical studiesAcute changesAcute damageTissue dissectionLong-term studiesSafe methodTissue effectsBrief burstsHistological sectionsOnly tissueTissuePorcine kidneyHilumDiscernible damageSignificant changesSame tissueScansPorcine tissuesDamageEvaluation of Optimal Stent Size After Endourologic Incision of Ureteral Strictures
Moon Y, Kerbl K, Pearle M, Gardner S, McDougall E, Humphrey P, Clayman R. Evaluation of Optimal Stent Size After Endourologic Incision of Ureteral Strictures. Journal Of Endourology 1995, 9: 15-22. PMID: 7780426, DOI: 10.1089/end.1995.9.15.Peer-Reviewed Original Research
1994
Comparison of Retrograde Endo-Pyelotomy and Endo-Balloon Rupture of the Ureteropelvic Junction in a Porcine Model
Pearle M, Moon Y, Endicott R, Gardner S, Humphrey P, Clayman R. Comparison of Retrograde Endo-Pyelotomy and Endo-Balloon Rupture of the Ureteropelvic Junction in a Porcine Model. Journal Of Urology 1994, 152: 2232-2239. PMID: 7966717, DOI: 10.1016/s0022-5347(17)31649-x.Peer-Reviewed Original ResearchConceptsUreteropelvic junctionRetroperitoneal extravasationRetrograde pyelogramStent removalUreteral stentsAdventitial layerSecondary ureteropelvic junction obstructionPatent ureteropelvic junctionDouble pigtail ureteral stentUreteropelvic junction obstructionFemale farm pigsChronic study animalsPigtail ureteral stentChronic animal studiesNormal ureteropelvic junctionBalloon distentionBalloon incisionUrine extravasationAcute groupLinear tearChronic groupChronic inflammationMild fibrosisJunction obstructionCommon finding