2001
Impaired prostate tumorigenesis in Egr1-deficient mice
Abdulkadir S, Qu Z, Garabedian E, Song S, Peters T, Svaren J, Carbone J, Naughton C, Catalona W, Ackerman J, Gordon J, Humphrey P, Milbrandt J. Impaired prostate tumorigenesis in Egr1-deficient mice. Nature Medicine 2001, 7: 101-107. PMID: 11135623, DOI: 10.1038/83231.Peer-Reviewed Original ResearchConceptsEarly growth response protein 1Prostate cancerTumor progressionProstatic intra-epithelial neoplasiaEgr1 deficiencyIntra-epithelial neoplasiaHigh-resolution magnetic resonance imagingTransgenic mouse modelHuman prostate cancerTumor growth rateEgr1-deficient miceMagnetic resonance imagingProstate tumor progressionMouse modelProstate tumorigenesisSurvival analysisResonance imagingCarcinomaTumor developmentProtein 1ProgressionCancerMiceDeficiencyEGR1
2000
WT1 Staining Reliably Differentiates Desmoplastic Small Round Cell Tumor From Ewing Sarcoma/Primitive Neuroectodermal Tumor
Hill D, Pfeifer J, Marley E, Dehner L, Humphrey P, Zhu X, Swanson P. WT1 Staining Reliably Differentiates Desmoplastic Small Round Cell Tumor From Ewing Sarcoma/Primitive Neuroectodermal Tumor. American Journal Of Clinical Pathology 2000, 114: 345-353. PMID: 10989634, DOI: 10.1093/ajcp/114.3.345.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal NeoplasmsAdolescentAdultBiomarkers, TumorBlotting, SouthernChildChild, PreschoolDiagnosis, DifferentialDNA PrimersDNA, NeoplasmDNA-Binding ProteinsFemaleFibromatosis, AggressiveHumansImmunoenzyme TechniquesMaleNeuroectodermal Tumors, PrimitiveOncogene Proteins, FusionParotid NeoplasmsReverse Transcriptase Polymerase Chain ReactionSarcoma, EwingSequence Analysis, DNATranscription FactorsWT1 ProteinsConceptsDesmoplastic small round cell tumorSmall round cell tumorRound cell tumorEWS/PNETSarcoma/primitive neuroectodermal tumorPrimitive neuroectodermal tumorCell tumorsWT1 antibodyImmunohistochemical featuresNeuroectodermal tumorDiagnosis of DSRCTMalignant small round cell tumorEwing sarcoma/primitive neuroectodermal tumorEWS/PNETsRT-PCRReverse transcriptase-polymerase chain reaction analysisTranscriptase-polymerase chain reaction analysisWT1 stainingEWS-WT1 fusionChain reaction analysisPredictive valueTumorsAvailable tissue
1994
Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells.
Day M, Zhao X, Wu S, Swanson P, Humphrey P. Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells. Molecular Cancer Research 1994, 5: 735-41. PMID: 7947388.Peer-Reviewed Original ResearchMeSH KeywordsAlkaloidsAndrogensApoptosisCarcinomaDNA DamageDNA, NeoplasmDNA-Binding ProteinsEarly Growth Response Protein 1Enzyme InductionGene Expression Regulation, NeoplasticHumansImmediate-Early ProteinsMaleNeoplasms, Hormone-DependentProstatic NeoplasmsProtein KinasesProto-Oncogene Proteins c-fosStaurosporineTetradecanoylphorbol AcetateTranscription FactorsTranscriptional ActivationTumor Cells, CulturedConceptsTranscription factor NGFIPhorbol ester-induced apoptosisC-fos gene activationEarly transcriptional regulationKinase signal transductionC-fosProtein kinase activatorsProstate cellsTranscriptional regulationGene activationSignal transductionProtein kinaseInduction of deathKinase activatorLNCaP cellsProstate cancer cellsProstate linesApoptotic bodiesCell deathDNA ladderTransient activationTransient inductionIntracellular pathwaysTPA-induced expressionNGFI