2018
Genomic Heterogeneity and the Small Renal Mass
Ueno D, Xie Z, Boeke M, Syed J, Nguyen KA, McGillivray P, Adeniran A, Humphrey P, Dancik GM, Kluger Y, Liu Z, Kluger H, Shuch B. Genomic Heterogeneity and the Small Renal Mass. Clinical Cancer Research 2018, 24: 4137-4144. PMID: 29760223, PMCID: PMC6125159, DOI: 10.1158/1078-0432.ccr-18-0214.Peer-Reviewed Original Research
2006
Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger
Wild P, Giedl J, Stoehr R, Junker K, Boehm S, van Oers J, Zwarthoff E, Blaszyk H, Fine S, Humphrey P, Dehner L, Amin M, Epstein J, Hartmann A. Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger. The Journal Of Pathology 2006, 211: 18-25. PMID: 17072825, DOI: 10.1002/path.2075.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlphapapillomavirusChildChild, PreschoolChromosome AberrationsChromosomes, Human, Pair 9DNA Mismatch RepairDNA Mutational AnalysisDNA, ViralFemaleGene Expression ProfilingGenes, p53HumansImmunohistochemistryIn Situ Hybridization, FluorescenceLoss of HeterozygosityMaleMicrosatellite InstabilityOligonucleotide Array Sequence AnalysisPapillomaPolymerase Chain ReactionReceptor, Fibroblast Growth Factor, Type 3Urologic NeoplasmsUrotheliumConceptsPatients 19 yearsUrothelial neoplasmsUrothelial papillomaMicrosatellite instabilityClinical outcomesHuman papillomavirusTP53 mutationsHigh-grade papillary urothelial carcinomaNIH consensus panelEvidence of diseaseFavorable clinical outcomeLow malignant potentialChromosome arm 9pPapillary urothelial carcinomaComparative genomic hybridizationPapillary urothelial neoplasmHPV positivityYounger patientsMultifocal tumorsUrothelial carcinomaUrothelial tumorsMalignant potentialPolymerase chain reactionConsensus panelKi-67
2001
The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate Cancer
Vollmer R, Humphrey P. The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate Cancer. American Journal Of Clinical Pathology 2001, 116: 864-870. PMID: 11764075, DOI: 10.1309/7mq7-mwar-4w8a-r75f.Peer-Reviewed Original ResearchConceptsElevated PSA levelsEarly deathPSA levelsRadical prostatectomyProstate cancerPathology observationsGleason grade 5Overall good prognosisTime of prostatectomyPostoperative levelsPSA failureStudy patientsBetter prognosisProgressive tumorsPrognostic categoriesPercentage carcinomaProstatectomySubsequent outcomesLower hazardDeathSurgeryHigher hazardCancerMenPSAChromosome 22q dosage in composite extrarenal rhabdoid tumors: Clonal evolution or a phenotypic mimic?
Fuller C, Pfeifer J, Humphrey P, Bruch L, Dehner L, Perry A. Chromosome 22q dosage in composite extrarenal rhabdoid tumors: Clonal evolution or a phenotypic mimic? Human Pathology 2001, 32: 1102-1108. PMID: 11679945, DOI: 10.1053/hupa.2001.28252.Peer-Reviewed Original ResearchVisceral primitive peripheral neuroectodermal tumors: A clinicopathologic and molecular study
O'Sullivan M, Perlman E, Furman J, Humphrey P, Dehner L, Pfeifer J. Visceral primitive peripheral neuroectodermal tumors: A clinicopathologic and molecular study. Human Pathology 2001, 32: 1109-1115. PMID: 11679946, DOI: 10.1053/hupa.2001.28247.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal NeoplasmsAdolescentAdultBiomarkers, TumorDNA PrimersDNA, NeoplasmFemaleHumansImmunoenzyme TechniquesMaleMiddle AgedNeoplasm ProteinsNeuroectodermal Tumors, Primitive, PeripheralOncogene Proteins, FusionProto-Oncogene Protein c-fli-1Reverse Transcriptase Polymerase Chain ReactionRNA, MessengerRNA, NeoplasmRNA-Binding Protein EWSSarcoma, EwingSoft Tissue NeoplasmsTomography, X-Ray ComputedTranscription FactorsVisceraConceptsEWS/PNETSoft tissuePediatric small round blue cell tumorsSarcoma-primitive neuroectodermal tumorPolymerase chain reaction-based testingFusion transcriptsSmall round blue cell tumorsRound blue cell tumorsBlue cell tumorsClinicopathologic spectrumVisceral sitesPrognostic significanceVisceral originVisceral tumorsCell tumorsNeuroectodermal tumorAdditional casesTumorsPNETYoung adultsGenetic alterationsEts transcription factor familyBoneChromosomal translocationsEWS-FLI1
2000
Renal Cell Carcinoma With Rhabdoid Features
Gökden N, Nappi O, Swanson P, Pfeifer J, Vollmer R, Wick M, Humphrey P. Renal Cell Carcinoma With Rhabdoid Features. The American Journal Of Surgical Pathology 2000, 24: 1329-1338. PMID: 11023094, DOI: 10.1097/00000478-200010000-00002.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaAdult renal cell carcinomaGlial fibrillary acidic proteinEpithelial membrane antigenNeuron-specific enolaseMuscle-specific actinSmooth muscle actinCases of RCCRhabdoid featuresCell carcinomaRhabdoid componentRhabdoid elementsRhabdoid tumorIncidence of RCCGrade 4 casesGrade 2 casesRadical nephrectomy specimensGrade I casesFibrillary acidic proteinGrade 3 casesPanel of antibodiesLarge epithelioid cellsIntracytoplasmic hyaline globulesHigh-stage carcinomasMajority of casesVisual estimate of the percentage of carcinoma is an independent predictor of prostate carcinoma recurrence after radical prostatectomy
Carvalhal G, Humphrey P, Thorson P, Yan Y, Ramos C, Catalona W. Visual estimate of the percentage of carcinoma is an independent predictor of prostate carcinoma recurrence after radical prostatectomy. Cancer 2000, 89: 1308-1314. PMID: 11002227, DOI: 10.1002/1097-0142(20000915)89:6<1308::aid-cncr16>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsPercentage of carcinomaGroup of patientsDisease recurrenceRadical prostatectomyRadical prostatectomy specimensIndependent predictorsPathologic stageGleason scoreTumor recurrenceProstate carcinomaProstatectomy specimensPreoperative prostate-specific antigen levelProstate-specific antigen levelKaplan-Meier product limit estimatesCox proportional hazards modelProstatic tissue specimensPathologic tumor stageKaplan-Meier methodRecurrence-free survivalSpecific antigen levelsImportant prognostic informationCox proportional hazardsProportional hazards modelProstate carcinoma recurrenceTumor size measurementsWT1 Staining Reliably Differentiates Desmoplastic Small Round Cell Tumor From Ewing Sarcoma/Primitive Neuroectodermal Tumor
Hill D, Pfeifer J, Marley E, Dehner L, Humphrey P, Zhu X, Swanson P. WT1 Staining Reliably Differentiates Desmoplastic Small Round Cell Tumor From Ewing Sarcoma/Primitive Neuroectodermal Tumor. American Journal Of Clinical Pathology 2000, 114: 345-353. PMID: 10989634, DOI: 10.1093/ajcp/114.3.345.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal NeoplasmsAdolescentAdultBiomarkers, TumorBlotting, SouthernChildChild, PreschoolDiagnosis, DifferentialDNA PrimersDNA, NeoplasmDNA-Binding ProteinsFemaleFibromatosis, AggressiveHumansImmunoenzyme TechniquesMaleNeuroectodermal Tumors, PrimitiveOncogene Proteins, FusionParotid NeoplasmsReverse Transcriptase Polymerase Chain ReactionSarcoma, EwingSequence Analysis, DNATranscription FactorsWT1 ProteinsConceptsDesmoplastic small round cell tumorSmall round cell tumorRound cell tumorEWS/PNETSarcoma/primitive neuroectodermal tumorPrimitive neuroectodermal tumorCell tumorsWT1 antibodyImmunohistochemical featuresNeuroectodermal tumorDiagnosis of DSRCTMalignant small round cell tumorEwing sarcoma/primitive neuroectodermal tumorEWS/PNETsRT-PCRReverse transcriptase-polymerase chain reaction analysisTranscriptase-polymerase chain reaction analysisWT1 stainingEWS-WT1 fusionChain reaction analysisPredictive valueTumorsAvailable tissueSquamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association
Cook J, Hill D, Humphrey P, Pfeifer J, El-Mofty S. Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association. Modern Pathology 2000, 13: 914-918. PMID: 10955460, DOI: 10.1038/modpathol.3880164.Peer-Reviewed Original ResearchConceptsRecurrent respiratory papillomatosisSquamous cell carcinomaJuvenile-onset recurrent respiratory papillomatosisRespiratory papillomatosisCell carcinomaClinical featuresInvasive carcinomaHPV-11Malignant transformationFatal squamous cell carcinomaHuman papillomavirus typingHPV 11 DNASimilar clinical featuresYoung adult menPulmonary papillomaPulmonary involvementSquamous papillomaHPV typingBenign papillomasPapillomatosisSerotype associationCarcinomaAdult menPapillomasLungConcurrent Ki-67 and p53 Immunolabeling in Cutaneous Melanocytic Neoplasms: An Adjunct for Recognition of the Vertical Growth Phase in Malignant Melanomas?
Kaleem Z, Lind A, Humphrey P, Sueper R, Swanson P, Ritter J, Wick M. Concurrent Ki-67 and p53 Immunolabeling in Cutaneous Melanocytic Neoplasms: An Adjunct for Recognition of the Vertical Growth Phase in Malignant Melanomas? Modern Pathology 2000, 13: 217-222. PMID: 10757331, DOI: 10.1038/modpathol.3880040.Peer-Reviewed Original Research
1998
Clinical and pathologic tumor characteristics of prostate cancer as a function of the number of biopsy cores: a retrospective study
Naughton C, Smith D, Humphrey P, Catalona W, Keetch D. Clinical and pathologic tumor characteristics of prostate cancer as a function of the number of biopsy cores: a retrospective study. Urology 1998, 52: 808-813. PMID: 9801104, DOI: 10.1016/s0090-4295(98)00344-6.Peer-Reviewed Original ResearchConceptsProstate cancerBiopsy coresCore biopsySextant core biopsiesProstate volumeTotal prostate-specific antigen valuesProstate-specific antigen valuesMore biopsy coresMore biopsy sessionsPathologic tumor characteristicsPathologic tumor featuresSix-core biopsyTotal biopsy coresTRUS prostate volumeNegative prostate biopsyClinical prostate cancerMore biopsy samplesProstate cancer detectionPSA densityProspective trialInitial biopsyPathologic characteristicsProstatic volumeSerum tPSATumor characteristics
1997
CT of cystic renal masses: analysis of diagnostic performance and interobserver variation.
Siegel C, McFarland E, Brink J, Fisher A, Humphrey P, Heiken J. CT of cystic renal masses: analysis of diagnostic performance and interobserver variation. American Journal Of Roentgenology 1997, 169: 813-8. PMID: 9275902, DOI: 10.2214/ajr.169.3.9275902.Peer-Reviewed Original ResearchMetastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal Samples
Mallow D, Humphrey P, Soper J, Johnston W. Metastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal Samples. Acta Cytologica 1997, 41: 549-555. PMID: 9100797, DOI: 10.1159/000332555.Peer-Reviewed Original ResearchConceptsMetastatic lobular carcinomaLobular carcinomaCervicovaginal samplesCervicovaginal smearsHuman milk fat globule membraneEpithelial membrane antigenEpidermal growth factor receptorExtragenital originExtrauterine cancerGrowth factor receptorMalignant tumorsTherapeutic implicationsMembrane antigenCarcinoembryonic antigenHistologic correlationFactor receptorMarker studiesCarcinomaMilk fat globule membraneBreastAntigenSmearsFat globule membraneGlobule membraneTumors
1994
Overexpression of p53 Is Not a Feature of Benign and Early-Stage Borderline Epithelial Ovarian Tumors
Berchuck A, Kohler M, Hopkins M, Humphrey P, Robboy S, Rodriguez G, Soper J, Clarke-Pearson D, Bast R. Overexpression of p53 Is Not a Feature of Benign and Early-Stage Borderline Epithelial Ovarian Tumors. Gynecologic Oncology 1994, 52: 232-236. PMID: 7508877, DOI: 10.1006/gyno.1994.1037.Peer-Reviewed Original ResearchConceptsEpithelial ovarian tumorsOverexpression of p53Borderline epithelial ovarian tumorsEpithelial ovarian cancerOvarian tumorsBorderline tumorsOvarian cancerEarly-stage borderline ovarian tumorsStage I/II casesBenign epithelial ovarian tumorsInvasive epithelial ovarian cancerBorderline ovarian tumorsBenign ovarian tumorsStage III casesAdvanced stage casesBenign tumorsMutant p53 proteinP53 tumor suppressor gene productIII casesStage casesTumorsII casesP53 proteinTumor suppressor gene productP53
1993
Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma
Ibrahim S, Lightner V, Ventimiglia J, Ibrahim G, Walther P, Bigner D, Humphrey P. Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma. Human Pathology 1993, 24: 982-989. PMID: 7504654, DOI: 10.1016/0046-8177(93)90112-t.Peer-Reviewed Original ResearchConceptsWestern blot analysisIntraepithelial neoplasiaCarcinoma cell linesProstatic hyperplasiaProstatic tissueBlot analysisAdult prostatic tissuesMetastatic prostatic carcinomaGrade of adenocarcinomaHuman prostatic carcinoma cell linesBone marrow samplesProstatic carcinoma cell linesHuman prostate tissueCell linesExpression of tenascinConnective tissue frameworkLymph nodesHistologic gradeProstatic carcinomaStromal alterationsTenascin immunoreactivityMarrow samplesStrong immunoreactivityStromal immunoreactivityProstate tissueIs Prostate Specific Antigen of Clinical Importance in Evaluating Outcome after Radical Prostatectomy
Frazier H, Robertson J, Humphrey P, Paulson D. Is Prostate Specific Antigen of Clinical Importance in Evaluating Outcome after Radical Prostatectomy. Journal Of Urology 1993, 149: 516-518. PMID: 7679755, DOI: 10.1016/s0022-5347(17)36132-3.Peer-Reviewed Original ResearchConceptsProstate-specific antigenPostoperative serum PSA levelsSerum PSA levelsPSA levelsPSA elevationSpecific antigenPostoperative prostate-specific antigenSerum prostate-specific antigenPostoperative PSA levelMargin-positive diseaseRadical perineal prostatectomySerum acid phosphatasePositive diseaseBone scanCurative therapyLocal recurrenceTreatment courseRadical prostatectomyMalignant diseasePerineal prostatectomyClinical failureProstate cancerPositive groupPatientsClinical importance
1992
Monoclonal antibodies to malignant human gliomas
Wikstrand C, Fredman P, Svennerholm L, Humphrey P, Bigner S, Bigner D. Monoclonal antibodies to malignant human gliomas. Journal Of Molecular Neuroscience 1992, 17: 137-146. PMID: 1384525, DOI: 10.1007/bf03159988.Peer-Reviewed Original ResearchConceptsPrimary CNS neoplasmsCNS neoplasmsHuman gliomasMonoclonal antibodiesMalignant brain tumorsHuman glioma xenograftsMalignant human gliomasAdult human brainNormal adult tissuesMAb localizationSpecific monoclonal antibodiesGlioma xenograftsBrain tumorsCytologic specimensFrozen sectionsEpitopic specificityGlioma biopsiesEGFR geneNeoplasmsGliomasVivo diagnosisMutant EGFREGFR proteinAntibodiesTumors
1991
Histologic Grade, DNA Ploidy, and Intraglandular Tumor Extent as Indicators of Tumor Progression of Clinical Stage B Prostatic Carcinoma
Humphrey P, Walther P, Currin S, Vollmer R. Histologic Grade, DNA Ploidy, and Intraglandular Tumor Extent as Indicators of Tumor Progression of Clinical Stage B Prostatic Carcinoma. The American Journal Of Surgical Pathology 1991, 15: 1165-1170. PMID: 1746683, DOI: 10.1097/00000478-199112000-00007.Peer-Reviewed Original ResearchConceptsHistologic gradeDNA ploidyTumor progressionTumor areaClinical stage B adenocarcinomaIntraglandular tumor extentStage B adenocarcinomaIndependent predictive factorsCox model analysisLikelihood of aneuploidyLogistic regression modelsB adenocarcinomaPredictive factorsTumor extensionProstatic carcinomaTumor extentProstatectomy specimensMultivariate analysisConcurrent useProgressionAdditional predictive abilityProstateImportant predictorRegression models