2001
Chromosome 22q dosage in composite extrarenal rhabdoid tumors: Clonal evolution or a phenotypic mimic?
Fuller C, Pfeifer J, Humphrey P, Bruch L, Dehner L, Perry A. Chromosome 22q dosage in composite extrarenal rhabdoid tumors: Clonal evolution or a phenotypic mimic? Human Pathology 2001, 32: 1102-1108. PMID: 11679945, DOI: 10.1053/hupa.2001.28252.Peer-Reviewed Original Research
1997
Assessment of Clonality in Cutaneous Lymphoid Infiltrates by Polymerase Chain Reaction Analysis of Immunoglobulin Heavy Chain Gene Rearrangement
Ritter J, Wick M, Adesokan P, Fitzgibbon J, Zhu X, Humphrey P. Assessment of Clonality in Cutaneous Lymphoid Infiltrates by Polymerase Chain Reaction Analysis of Immunoglobulin Heavy Chain Gene Rearrangement. American Journal Of Clinical Pathology 1997, 108: 60-68. PMID: 9208979, DOI: 10.1093/ajcp/108.1.60.Peer-Reviewed Original ResearchConceptsCutaneous lymphoid infiltratesPolymerase chain reactionLymphoid infiltratesMonoclonal bandImmunoglobulin heavy chain geneFalse-positive resultsT cellsCell lymphomaB cellsValue of PCRLarge cell casesSparse perivascular infiltrateImmunoglobulin heavy chain gene rearrangementMixed cell lymphomaLarge cell lymphomaB-cell immunophenotypeHeavy chain gene rearrangementHeavy chain geneAssessment of clonalityChain gene rearrangementPerivascular infiltratesClinical featuresPolymerase chain reaction analysisClinical findingsMixed lesions
1992
Clonal Origin of Epithelial Ovarian Carcinoma: Analysis by Loss of Heterozygosity, p53 Mutation, and X-Chromosome Inactivation
Jacobs I, Kohler M, Wiseman R, Marks J, Whitaker R, Kerns B, Humphrey P, Berchuck A, Ponder B, Bast R. Clonal Origin of Epithelial Ovarian Carcinoma: Analysis by Loss of Heterozygosity, p53 Mutation, and X-Chromosome Inactivation. Journal Of The National Cancer Institute 1992, 84: 1793-1798. PMID: 1433368, DOI: 10.1093/jnci/84.23.1793.Peer-Reviewed Original ResearchConceptsEpithelial ovarian carcinomaOvarian cancerOvarian carcinomaTumor depositsPrimary tumorPolyclonal diseaseLoss of heterozygosityClonal originSporadic epithelial ovarian carcinomaMultiple tumour depositsMonoclonal originMultiple primary tumorsPrimary ovarian tumorsPrimary ovarian cancerHereditary ovarian cancerPeripheral blood lymphocytesP53 gene mutationsX-chromosome inactivation analysisMetastatic depositsOvarian tumorsBlood lymphocytesPeritoneal surfacePeritoneal mesotheliumClinical strategiesP53 mutations