2001
Visceral primitive peripheral neuroectodermal tumors: A clinicopathologic and molecular study
O'Sullivan M, Perlman E, Furman J, Humphrey P, Dehner L, Pfeifer J. Visceral primitive peripheral neuroectodermal tumors: A clinicopathologic and molecular study. Human Pathology 2001, 32: 1109-1115. PMID: 11679946, DOI: 10.1053/hupa.2001.28247.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal NeoplasmsAdolescentAdultBiomarkers, TumorDNA PrimersDNA, NeoplasmFemaleHumansImmunoenzyme TechniquesMaleMiddle AgedNeoplasm ProteinsNeuroectodermal Tumors, Primitive, PeripheralOncogene Proteins, FusionProto-Oncogene Protein c-fli-1Reverse Transcriptase Polymerase Chain ReactionRNA, MessengerRNA, NeoplasmRNA-Binding Protein EWSSarcoma, EwingSoft Tissue NeoplasmsTomography, X-Ray ComputedTranscription FactorsVisceraConceptsEWS/PNETSoft tissuePediatric small round blue cell tumorsSarcoma-primitive neuroectodermal tumorPolymerase chain reaction-based testingFusion transcriptsSmall round blue cell tumorsRound blue cell tumorsBlue cell tumorsClinicopathologic spectrumVisceral sitesPrognostic significanceVisceral originVisceral tumorsCell tumorsNeuroectodermal tumorAdditional casesTumorsPNETYoung adultsGenetic alterationsEts transcription factor familyBoneChromosomal translocationsEWS-FLI1Primitive Neuroectodermal Tumors of the Biliary and Gastrointestinal Tracts: Clinicopathologic and Molecular Diagnostic Study of Two Cases
Sarangarajan R, Hill D, Humphrey P, Hitchcock M, Dehner L, Pfeifer J. Primitive Neuroectodermal Tumors of the Biliary and Gastrointestinal Tracts: Clinicopathologic and Molecular Diagnostic Study of Two Cases. Pediatric And Developmental Pathology 2001, 4: 185-191. PMID: 11178636, DOI: 10.1007/s100240010141.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBile Duct NeoplasmsBiomarkers, TumorDNA PrimersDNA, NeoplasmFemaleHepatic Duct, CommonHumansImmunoenzyme TechniquesJejunal NeoplasmsMaleNeoplasm ProteinsNeoplasms, Second PrimaryNeuroectodermal Tumors, Primitive, PeripheralReverse Transcriptase Polymerase Chain ReactionRNA, NeoplasmSequence Analysis, DNAWilms TumorConceptsPrimitive neuroectodermal tumorNeuroectodermal tumorMalignant small round cell tumorMalignant soft tissue tumorsSmall round cell tumorSoft tissue tumorsRound cell tumorNon-classical sitesMore conventional sitesEWS-FLI1 gene fusionMolecular diagnostic studiesTranscription-polymerase chain reaction analysisCharacteristic immunoreactivityHepatic ductCell tumorsClinicopathologic profileTissue tumorsGastrointestinal tractChain reaction analysisUnusual siteSmall intestineTumorsMolecular findingsTumor cellsDiagnostic studies
2000
WT1 Staining Reliably Differentiates Desmoplastic Small Round Cell Tumor From Ewing Sarcoma/Primitive Neuroectodermal Tumor
Hill D, Pfeifer J, Marley E, Dehner L, Humphrey P, Zhu X, Swanson P. WT1 Staining Reliably Differentiates Desmoplastic Small Round Cell Tumor From Ewing Sarcoma/Primitive Neuroectodermal Tumor. American Journal Of Clinical Pathology 2000, 114: 345-353. PMID: 10989634, DOI: 10.1093/ajcp/114.3.345.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal NeoplasmsAdolescentAdultBiomarkers, TumorBlotting, SouthernChildChild, PreschoolDiagnosis, DifferentialDNA PrimersDNA, NeoplasmDNA-Binding ProteinsFemaleFibromatosis, AggressiveHumansImmunoenzyme TechniquesMaleNeuroectodermal Tumors, PrimitiveOncogene Proteins, FusionParotid NeoplasmsReverse Transcriptase Polymerase Chain ReactionSarcoma, EwingSequence Analysis, DNATranscription FactorsWT1 ProteinsConceptsDesmoplastic small round cell tumorSmall round cell tumorRound cell tumorEWS/PNETSarcoma/primitive neuroectodermal tumorPrimitive neuroectodermal tumorCell tumorsWT1 antibodyImmunohistochemical featuresNeuroectodermal tumorDiagnosis of DSRCTMalignant small round cell tumorEwing sarcoma/primitive neuroectodermal tumorEWS/PNETsRT-PCRReverse transcriptase-polymerase chain reaction analysisTranscriptase-polymerase chain reaction analysisWT1 stainingEWS-WT1 fusionChain reaction analysisPredictive valueTumorsAvailable tissueSquamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association
Cook J, Hill D, Humphrey P, Pfeifer J, El-Mofty S. Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association. Modern Pathology 2000, 13: 914-918. PMID: 10955460, DOI: 10.1038/modpathol.3880164.Peer-Reviewed Original ResearchConceptsRecurrent respiratory papillomatosisSquamous cell carcinomaJuvenile-onset recurrent respiratory papillomatosisRespiratory papillomatosisCell carcinomaClinical featuresInvasive carcinomaHPV-11Malignant transformationFatal squamous cell carcinomaHuman papillomavirus typingHPV 11 DNASimilar clinical featuresYoung adult menPulmonary papillomaPulmonary involvementSquamous papillomaHPV typingBenign papillomasPapillomatosisSerotype associationCarcinomaAdult menPapillomasLung