1998
Lymphoid Lesions of the Gastrointestinal Tract: A Histologic, Immunophenotypic, and Genotypic Analysis of 49 Cases
O’Sullivan M, Ritter J, Humphrey P, Wick M. Lymphoid Lesions of the Gastrointestinal Tract: A Histologic, Immunophenotypic, and Genotypic Analysis of 49 Cases. American Journal Of Clinical Pathology 1998, 110: 471-477. PMID: 9763033, DOI: 10.1093/ajcp/110.4.471.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDAntigens, CD20Digestive SystemGastrointestinal NeoplasmsGene RearrangementGenotypeHumansImmunoglobulin Heavy ChainsImmunophenotypingKi-67 AntigenLeukemia, Lymphocytic, Chronic, B-CellLeukocyte Common AntigensLeukosialinLymphoid TissueLymphomaLymphoma, Large B-Cell, DiffusePolymerase Chain ReactionSialoglycoproteinsConceptsLymphoid infiltratesMalignant neoplasmsPolymerase chain reactionMalignant lesionsLow-grade malignant neoplasmAvailable diagnostic modalitiesLight microscopic criteriaParaffin-embedded specimensGenotypic analysisGI biopsy specimensConventional microscopic assessmentClinical evidenceClinical outcomesBiopsy specimensLymphoid lesionsCytologic atypiaImmunohistochemical stainsDiagnostic modalitiesGastrointestinal tractMonoclonal bandBenign lesionsDiagnostic standardEnd pointInfiltratesLesions
1997
Assessment of Clonality in Cutaneous Lymphoid Infiltrates by Polymerase Chain Reaction Analysis of Immunoglobulin Heavy Chain Gene Rearrangement
Ritter J, Wick M, Adesokan P, Fitzgibbon J, Zhu X, Humphrey P. Assessment of Clonality in Cutaneous Lymphoid Infiltrates by Polymerase Chain Reaction Analysis of Immunoglobulin Heavy Chain Gene Rearrangement. American Journal Of Clinical Pathology 1997, 108: 60-68. PMID: 9208979, DOI: 10.1093/ajcp/108.1.60.Peer-Reviewed Original ResearchConceptsCutaneous lymphoid infiltratesPolymerase chain reactionLymphoid infiltratesMonoclonal bandImmunoglobulin heavy chain geneFalse-positive resultsT cellsCell lymphomaB cellsValue of PCRLarge cell casesSparse perivascular infiltrateImmunoglobulin heavy chain gene rearrangementMixed cell lymphomaLarge cell lymphomaB-cell immunophenotypeHeavy chain gene rearrangementHeavy chain geneAssessment of clonalityChain gene rearrangementPerivascular infiltratesClinical featuresPolymerase chain reaction analysisClinical findingsMixed lesions
1991
Deletion-mutant epidermal growth factor receptor in human gliomas: Effect of type II mutation on receptor function
Humphrey P, Gangarosa L, Wong A, Archer G, Lund-Johansen M, Bjerkvig R, Laerum O, Friedman H, Bigner D. Deletion-mutant epidermal growth factor receptor in human gliomas: Effect of type II mutation on receptor function. Biochemical And Biophysical Research Communications 1991, 178: 1413-1420. PMID: 1678600, DOI: 10.1016/0006-291x(91)91051-d.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceCell LineChromosome DeletionEpidermal Growth FactorErbB ReceptorsGene AmplificationGene RearrangementGliomaHumansKineticsMolecular Sequence DataPhosphorylationProtein-Tyrosine KinasesProto-Oncogene MasProto-Oncogene ProteinsProto-OncogenesReceptor, ErbB-2Transforming Growth Factor alphaConceptsEGFR kinase activityMutant EGFRDeletion-mutant epidermal growth factor receptorGrowth factor receptor geneMutant EGFR proteinEpidermal growth factor receptorGrowth factorFactor receptor geneEpidermal growth factor receptor (EGFR) geneGrowth factor receptorKinase activityExtracellular domainGlioma cell proliferationDomain IVFrame deletionType II mutationAmino acidsEGFR proteinFactor receptorReceptor geneThree-dimensional spheroid modelCell proliferationReceptor functionEGFHuman gliomas