The early detection of prostate carcinoma with prostate specific antigen
Smith D, Humphrey P, Catalona W. The early detection of prostate carcinoma with prostate specific antigen. Cancer 1997, 80: 1852-1856. PMID: 9351559, DOI: 10.1002/(sici)1097-0142(19971101)80:9<1852::aid-cncr25>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsDigital rectal examinationSubset of menPositive predictive valueSignificant carcinomaPSA levelsRectal examinationProstate carcinomaPredictive valueScreening testDigital rectal examination resultsIntermediate outcomesCarcinoma detection rateEarly prostate carcinomaScreen-detected carcinomasScreen-detected tumorsInitial PSA levelReasonable positive predictive valueMajority of tumorsProstate-specific antigenProportion of menPathologic characteristicsClinicopathologic featuresPathologic featuresProstatic biopsyDisease stage