2024
Sarcomatoid and Rhabdoid Renal Cell Carcinoma
Adeniran A, Shuch B, Humphrey P. Sarcomatoid and Rhabdoid Renal Cell Carcinoma. The American Journal Of Surgical Pathology 2024, 48: e65-e88. PMID: 38736105, DOI: 10.1097/pas.0000000000002233.Peer-Reviewed Original ResearchRenal cell carcinomaSarcomatoid renal cell carcinomaGenomic alterationsRhabdoid differentiationRhabdoid cellsCell carcinomaWHO classification of renal tumorsClassification of renal tumorsInternational Collaboration on Cancer ReportingHistologic types of renal cell carcinomaPleomorphic undifferentiated sarcomaMalignant spindle cellsAggressive biological behaviorMolecular featuresMolecular mechanisms of tumorigenesisMechanisms of tumorigenesisSarcomatoid growthRhabdoid componentSarcomatoid componentRhabdoid featuresRenal tumorsClinical responseCollege of American PathologistsRhabdoid morphologySarcomatoid elements
2000
Renal Cell Carcinoma With Rhabdoid Features
Gökden N, Nappi O, Swanson P, Pfeifer J, Vollmer R, Wick M, Humphrey P. Renal Cell Carcinoma With Rhabdoid Features. The American Journal Of Surgical Pathology 2000, 24: 1329-1338. PMID: 11023094, DOI: 10.1097/00000478-200010000-00002.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaAdult renal cell carcinomaGlial fibrillary acidic proteinEpithelial membrane antigenNeuron-specific enolaseMuscle-specific actinSmooth muscle actinCases of RCCRhabdoid featuresCell carcinomaRhabdoid componentRhabdoid elementsRhabdoid tumorIncidence of RCCGrade 4 casesGrade 2 casesRadical nephrectomy specimensGrade I casesFibrillary acidic proteinGrade 3 casesPanel of antibodiesLarge epithelioid cellsIntracytoplasmic hyaline globulesHigh-stage carcinomasMajority of cases