Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts.
Colapinto E, Humphrey P, Zalutsky M, Groothuis D, Friedman H, de Tribolet N, Carrel S, Bigner D. Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts. Cancer Research 1988, 48: 5701-7. PMID: 3167830.Peer-Reviewed Original ResearchConceptsHuman glioma cell line DNormal tissuesSpecific tumor localizationHuman glioma xenograftsXenograft-bearing miceNormal tissue ratiosHigh radiation dosesImmunoglobulin G2aAthymic miceGlioma xenograftsBrain tumorsBrain tumor diagnosisTumor localizationHigh tumorTumor uptakeIntracranial xenograftsComparative localizationTherapeutic agentsMonoclonal antibodiesMAb fragmentsTissue ratioTumor diagnosisPotential agentRadiation dosesSelective delivery