Clonal Origin of Epithelial Ovarian Carcinoma: Analysis by Loss of Heterozygosity, p53 Mutation, and X-Chromosome Inactivation
Jacobs I, Kohler M, Wiseman R, Marks J, Whitaker R, Kerns B, Humphrey P, Berchuck A, Ponder B, Bast R. Clonal Origin of Epithelial Ovarian Carcinoma: Analysis by Loss of Heterozygosity, p53 Mutation, and X-Chromosome Inactivation. Journal Of The National Cancer Institute 1992, 84: 1793-1798. PMID: 1433368, DOI: 10.1093/jnci/84.23.1793.Peer-Reviewed Original ResearchConceptsEpithelial ovarian carcinomaOvarian cancerOvarian carcinomaTumor depositsPrimary tumorPolyclonal diseaseLoss of heterozygosityClonal originSporadic epithelial ovarian carcinomaMultiple tumour depositsMonoclonal originMultiple primary tumorsPrimary ovarian tumorsPrimary ovarian cancerHereditary ovarian cancerPeripheral blood lymphocytesP53 gene mutationsX-chromosome inactivation analysisMetastatic depositsOvarian tumorsBlood lymphocytesPeritoneal surfacePeritoneal mesotheliumClinical strategiesP53 mutations