2024
Final Overall Survival Analysis of S1500: A Randomized, Phase II Study Comparing Sunitinib With Cabozantinib, Crizotinib, and Savolitinib in Advanced Papillary Renal Cell Carcinoma.
Barata P, Tangen C, Plets M, Thompson I, Narayan V, George D, Heng D, Shuch B, Stein M, Gulati S, Tretiakova M, Tripathi A, Bjarnason G, Humphrey P, Adeniran A, Vaishampayan U, Alva A, Zhang T, Cole S, Lara P, Lerner S, Balzer-Haas N, Pal S. Final Overall Survival Analysis of S1500: A Randomized, Phase II Study Comparing Sunitinib With Cabozantinib, Crizotinib, and Savolitinib in Advanced Papillary Renal Cell Carcinoma. Journal Of Clinical Oncology 2024, jco2400767. PMID: 39255440, DOI: 10.1200/jco.24.00767.Peer-Reviewed Original ResearchAdvanced papillary renal cell carcinomaPapillary renal cell carcinomaRenal cell carcinomaOverall survivalCell carcinomaProlonged progression-free survivalLack of survival benefitProgression-free survivalRandomized phase IIMedian follow-upPrimary end pointOpen-label trialOverall survival analysisCrizotinib armMedian OSSurvival benefitClinical trial updateNo significant differenceCabozantinibTreatment armsSunitinibFollow-upClinical trialsSavolitinibCrizotinibPathological concordance rate and outcomes by subtype in advanced papillary renal cell carcinoma
Tripathi A, Tangen C, Plets M, Li X, Tretiakova M, Humphrey P, Adeniran A, Barata P, Gulati S, Bergerot C, Pruthi D, Thompson I, Lara P, Lerner S, Pal S, Shuch B. Pathological concordance rate and outcomes by subtype in advanced papillary renal cell carcinoma. BJU International 2024, 134: 596-601. PMID: 39014969, DOI: 10.1111/bju.16403.Peer-Reviewed Original ResearchPapillary renal cell carcinomaPositive predictive valueRenal cell carcinomaLocal pathology reviewCentral reviewPathology reviewCell carcinomaAdvanced papillary renal cell carcinomaMetastatic papillary renal cell carcinomaPapillary renal cell carcinoma subtypesPatients treated with targeted therapyExpert genitourinary pathologistsPathological concordance rateLocal reviewGenitourinary pathologistsClinical benefitCabozantinibClinical significanceClinical valueSubtype assignmentConcordance rateType 1CarcinomaPatientsPredictive valueSarcomatoid and Rhabdoid Renal Cell Carcinoma
Adeniran A, Shuch B, Humphrey P. Sarcomatoid and Rhabdoid Renal Cell Carcinoma. The American Journal Of Surgical Pathology 2024, 48: e65-e88. PMID: 38736105, DOI: 10.1097/pas.0000000000002233.Peer-Reviewed Original ResearchRenal cell carcinomaSarcomatoid renal cell carcinomaGenomic alterationsRhabdoid differentiationRhabdoid cellsCell carcinomaWHO classification of renal tumorsClassification of renal tumorsInternational Collaboration on Cancer ReportingHistologic types of renal cell carcinomaPleomorphic undifferentiated sarcomaMalignant spindle cellsAggressive biological behaviorMolecular featuresMolecular mechanisms of tumorigenesisMechanisms of tumorigenesisSarcomatoid growthRhabdoid componentSarcomatoid componentRhabdoid featuresRenal tumorsClinical responseCollege of American PathologistsRhabdoid morphologySarcomatoid elements
2016
The incidence of adverse pathologic characteristics in small renal masses as size increases.
Nawaf C, Rosoff J, Adeniran A, Humphrey P, Shuch B. The incidence of adverse pathologic characteristics in small renal masses as size increases. Journal Of Clinical Oncology 2016, 34: 596-596. DOI: 10.1200/jco.2016.34.2_suppl.596.Peer-Reviewed Original ResearchAdverse pathologic featuresRenal cell carcinomaActive surveillanceLymphovascular invasionPathologic featuresRenal massesAdverse pathologic characteristicsCT1a renal massesHistologic tumor necrosisRenal tumor biopsySelection of patientsSingle-institution databaseType II histologyHigh nuclear gradeTumor size categoriesSmall renal massesSignificant increaseSarcomatoid featuresPathologic characteristicsTumor sizeCell carcinomaPrimary tumorAUA guidelinesHistologic characteristicsLarge tumors
2007
Segmental disorders of the nephron: histopathological and imaging perspective
Prasad S, Narra V, Shah R, Humphrey P, Jagirdar J, Catena J, Dalrymple N, Siegel C. Segmental disorders of the nephron: histopathological and imaging perspective. British Journal Of Radiology 2007, 80: 593-602. PMID: 17621606, DOI: 10.1259/bjr/20129205.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaRenal disordersPapillary renal cell carcinomaAutosomal recessive polycystic kidney diseaseChromophobe renal cell carcinomaRecessive polycystic kidney diseaseRenin-secreting tumorMedullary collecting ductsCell of originPolycystic kidney diseaseHistopathological featuresDuct carcinomaCell carcinomaKidney diseaseMedullary carcinomaJuxtaglomerular cellsSegmental involvementClear cellsProximal tubulesRenal papillaCollecting ductsNephron disordersSegmental disorderCarcinomaDisorders
2000
Renal Cell Carcinoma With Rhabdoid Features
Gökden N, Nappi O, Swanson P, Pfeifer J, Vollmer R, Wick M, Humphrey P. Renal Cell Carcinoma With Rhabdoid Features. The American Journal Of Surgical Pathology 2000, 24: 1329-1338. PMID: 11023094, DOI: 10.1097/00000478-200010000-00002.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaAdult renal cell carcinomaGlial fibrillary acidic proteinEpithelial membrane antigenNeuron-specific enolaseMuscle-specific actinSmooth muscle actinCases of RCCRhabdoid featuresCell carcinomaRhabdoid componentRhabdoid elementsRhabdoid tumorIncidence of RCCGrade 4 casesGrade 2 casesRadical nephrectomy specimensGrade I casesFibrillary acidic proteinGrade 3 casesPanel of antibodiesLarge epithelioid cellsIntracytoplasmic hyaline globulesHigh-stage carcinomasMajority of casesSquamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association
Cook J, Hill D, Humphrey P, Pfeifer J, El-Mofty S. Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association. Modern Pathology 2000, 13: 914-918. PMID: 10955460, DOI: 10.1038/modpathol.3880164.Peer-Reviewed Original ResearchConceptsRecurrent respiratory papillomatosisSquamous cell carcinomaJuvenile-onset recurrent respiratory papillomatosisRespiratory papillomatosisCell carcinomaClinical featuresInvasive carcinomaHPV-11Malignant transformationFatal squamous cell carcinomaHuman papillomavirus typingHPV 11 DNASimilar clinical featuresYoung adult menPulmonary papillomaPulmonary involvementSquamous papillomaHPV typingBenign papillomasPapillomatosisSerotype associationCarcinomaAdult menPapillomasLung
1998
Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2
Vollmer R, Humphrey P, Swanson P, Wick M, Hudson M. Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2. Journal Of Urology 1998, 160: 1935-1936. DOI: 10.1016/s0022-5347(01)62455-8.Peer-Reviewed Original ResearchInvasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2
Vollmer R, Humphrey P, Swanson P, Wick M, Hudson M. Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2. Journal Of Urology 1998, 160: 1935-1936.. DOI: 10.1097/00005392-199811000-00095.Peer-Reviewed Original ResearchInvasion of the bladder by transitional cell carcinoma
Vollmer R, Humphrey P, Swanson P, Wick M, Hudson M. Invasion of the bladder by transitional cell carcinoma. Cancer 1998, 82: 715-723. PMID: 9477105, DOI: 10.1002/(sici)1097-0142(19980215)82:4<715::aid-cncr15>3.0.co;2-0.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorCarcinoma, Transitional CellEpidermal Growth FactorHumansImmunoenzyme TechniquesKi-67 AntigenLogistic ModelsNeoplasm InvasivenessNeoplasm ProteinsNeoplasm StagingPrognosisProspective StudiesProto-Oncogene Proteins c-bcl-2Receptor, ErbB-2Tumor Suppressor Protein p53Urinary Bladder NeoplasmsConceptsC-erb BTransitional cell carcinomaEpidermal growth factor receptorGrade 3 tumorsHistologic gradeMIB-1Cell carcinomaBcl-2Prognostic informationMultivariate logistic regression modelGrade 2 tumorsLogistic regression modelsWorld Health OrganizationGrowth factor receptorCombination of markersPrognostic factorsClinical outcomesProspective studyImmunohistochemical stainingPathologic levelsProtective effectLevel of invasionGrade 2Multivariate analysisCarcinoma
1997
Unusual Histologic Types of High-Grade Prostatic Intraepithelial Neoplasia
Reyes A, Swanson P, Carbone J, Humphrey P. Unusual Histologic Types of High-Grade Prostatic Intraepithelial Neoplasia. The American Journal Of Surgical Pathology 1997, 21: 1215-1222. PMID: 9331295, DOI: 10.1097/00000478-199710000-00013.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaSignet ring cellsSmall cell carcinoma cellsProstatic intraepithelial neoplasiaProstate-specific antigenInvasive carcinomaIntraepithelial neoplasiaPrimary signet-ring cell carcinomaGrade prostatic intraepithelial neoplasiaSignet ring cell carcinomaCases of HGPINCarcinoma cellsNeuron-specific enolaseProstatic cell typesUnusual histologic typeSmall cell neuroendocrineGlandular epithelial cellsArchitectural growth patternIntraepithelial proliferationMucinous distensionCell typesMucinous featuresStrength of associationHistologic typeCell carcinoma
1988
Pulmonary carcinomas with a sarcomatoid element: An immunocytochemical and ultrastructural analysis
Humphrey P, Scroggs M, Roggli V, Shelburne J. Pulmonary carcinomas with a sarcomatoid element: An immunocytochemical and ultrastructural analysis. Human Pathology 1988, 19: 155-165. PMID: 2449386, DOI: 10.1016/s0046-8177(88)80343-5.Peer-Reviewed Original ResearchConceptsSarcomatoid componentPulmonary carcinomaEpithelial differentiationSpindle cellsImmunocytochemical stainingSpindle cell populationSquamous cell carcinomaSpindle cell carcinomaSpindle cell componentUseful differentiating featureLight microscopyCell carcinomaPrimary carcinomaBiologic continuumBiphasic tumorSarcomatoid elementsUnusual neoplasmCarcinomaTumorsKeratin expressionUltrastructural examinationMesenchymal differentiationNeoplastic boneSharp demarcationUltrastructural analysis