2024
In vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjectsMultimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization
Vafaii H, Mandino F, Desrosiers-Grégoire G, O’Connor D, Markicevic M, Shen X, Ge X, Herman P, Hyder F, Papademetris X, Chakravarty M, Crair M, Constable R, Lake E, Pessoa L. Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization. Nature Communications 2024, 15: 229. PMID: 38172111, PMCID: PMC10764905, DOI: 10.1038/s41467-023-44363-z.Peer-Reviewed Original Research
2022
A 3D atlas of functional human brain energetic connectome based on neuropil distribution
Yu Y, Akif A, Herman P, Cao M, Rothman D, Carson R, Agarwal D, Evans A, Hyder F. A 3D atlas of functional human brain energetic connectome based on neuropil distribution. Cerebral Cortex 2022, 33: 3996-4012. PMID: 36104858, PMCID: PMC10068297, DOI: 10.1093/cercor/bhac322.Peer-Reviewed Original ResearchConceptsSynaptic densityCortical regionsHigher synapse densityHuman cortical circuitsFunctional imaging studiesCortical activity mapsVivo PET imagingNeuropil distributionGlucose oxidationSynapse densityCortical circuitsMetabolic rateSynaptic connectionsCortical energeticsImaging studiesHuman cortexPET imagingHistological stainingRecent evidenceCortexHuman brainBrainVoxel levelActivity ratesAtlas
2009
Fractal Characterization of Complexity in Dynamic Signals: Application to Cerebral Hemodynamics
Herman P, Kocsis L, Eke A. Fractal Characterization of Complexity in Dynamic Signals: Application to Cerebral Hemodynamics. Methods In Molecular Biology 2009, 489: 23-40. PMID: 18839086, DOI: 10.1007/978-1-59745-543-5_2.Peer-Reviewed Original ResearchConceptsCerebral hemodynamicsBrain cortexRat brain cortexLaser Doppler flowmetryAge-related stiffeningFunctional magnetic resonanceHemodynamic brain signalsDoppler flowmetryCerebral vasculatureTemporal lobeHuman studiesState of pathologyGray matterParenchymal regionsHemodynamic signalsHemodynamicsHuman brainCortexMagnetic resonanceMedical significance
2008
Towards a novel haemoglobin-based oxygen carrier: Euro-PEG-Hb, physico-chemical properties, vasoactivity and renal filtration
Portörő I, Kocsis L, Hermán P, Caccia D, Perrella M, Ronda L, Bruno S, Bettati S, Micalella C, Mozzarelli A, Varga A, Vas M, Lowe K, Eke A. Towards a novel haemoglobin-based oxygen carrier: Euro-PEG-Hb, physico-chemical properties, vasoactivity and renal filtration. Biochimica Et Biophysica Acta 2008, 1784: 1402-1409. PMID: 18405674, DOI: 10.1016/j.bbapap.2008.03.005.Peer-Reviewed Original Research
2006
Fractal and Noisy CBV Dynamics in Humans: Influence of Age and Gender
Eke A, Hermán P, Hajnal M. Fractal and Noisy CBV Dynamics in Humans: Influence of Age and Gender. Cerebrovascular And Brain Metabolism Reviews 2006, 26: 891-898. PMID: 16292253, DOI: 10.1038/sj.jcbfm.9600243.Peer-Reviewed Original ResearchMathematical model for the estimation of hemodynamic and oxygenation variables by tissue spectroscopy
Kocsis L, Herman P, Eke A. Mathematical model for the estimation of hemodynamic and oxygenation variables by tissue spectroscopy. Journal Of Theoretical Biology 2006, 241: 262-275. PMID: 16413035, DOI: 10.1016/j.jtbi.2005.11.033.Peer-Reviewed Original Research
1999
Fractal Analysis of Spontaneous Fluctuations in Human Cerebral Hemoglobin Content and its Oxygenation Level Recorded by NIRS
Eke A, Hermán P. Fractal Analysis of Spontaneous Fluctuations in Human Cerebral Hemoglobin Content and its Oxygenation Level Recorded by NIRS. Advances In Experimental Medicine And Biology 1999, 471: 49-55. PMID: 10659131, DOI: 10.1007/978-1-4615-4717-4_7.Peer-Reviewed Original ResearchConceptsBrain cortex